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Genomics of Megavirus and the elusive fourth domain of Life.
Commun Integr Biol. 2012 Jan 01; 5(1):102-6.CI

Abstract

We recently described Megavirus chilensis, a giant virus isolated off the coast of Chile, also replicating in fresh water acanthamoeba. Its 1,259,197-bp genome encodes 1,120 proteins and is the largest known viral genome. Megavirus and its closest relative Mimivirus only share 594 orthologous genes, themselves sharing only 50% of identical residues in average. Despite this divergence, comparable to the maximal divergence exhibited by bacteria within the same division (e.g., gamma proteobacteria), Megavirus retained all of the genomic features unique to Mimivirus, in particular its genes encoding key-elements of the translation apparatus, a trademark of cellular organisms. Besides homologs to the four aminoacyl-tRNA synthetases (aaRS) encoded by Mimivirus, Megavirus added three additional ones, raising the total of known virus-encoded aaRS to seven: IleRS, TrpRS, AsnRS, ArgRS, CysRS, MetRS, TyrRS. This finding strongly suggests that large DNA viruses derived from an ancestral cellular genome by reductive evolution. The nature of this cellular ancestor remains hotly debated.

Authors+Show Affiliations

Information Génomique et Structurale; Centre National de la Recherche Scientifique-Unité Propre de Recherche 2589; Aix-Marseille University; Institut de Microbiologie de la Méditerranée; Parc Scientifique de Luminy; Case 934; Marseille, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22482024

Citation

Legendre, Matthieu, et al. "Genomics of Megavirus and the Elusive Fourth Domain of Life." Communicative & Integrative Biology, vol. 5, no. 1, 2012, pp. 102-6.
Legendre M, Arslan D, Abergel C, et al. Genomics of Megavirus and the elusive fourth domain of Life. Commun Integr Biol. 2012;5(1):102-6.
Legendre, M., Arslan, D., Abergel, C., & Claverie, J. M. (2012). Genomics of Megavirus and the elusive fourth domain of Life. Communicative & Integrative Biology, 5(1), 102-6.
Legendre M, et al. Genomics of Megavirus and the Elusive Fourth Domain of Life. Commun Integr Biol. 2012 Jan 1;5(1):102-6. PubMed PMID: 22482024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genomics of Megavirus and the elusive fourth domain of Life. AU - Legendre,Matthieu, AU - Arslan,Defne, AU - Abergel,Chantal, AU - Claverie,Jean-Michel, PY - 2012/4/7/entrez PY - 2012/4/7/pubmed PY - 2012/4/7/medline KW - Girus KW - Megaviridae KW - Short read sequencing KW - Tree of Life SP - 102 EP - 6 JF - Communicative & integrative biology JO - Commun Integr Biol VL - 5 IS - 1 N2 - We recently described Megavirus chilensis, a giant virus isolated off the coast of Chile, also replicating in fresh water acanthamoeba. Its 1,259,197-bp genome encodes 1,120 proteins and is the largest known viral genome. Megavirus and its closest relative Mimivirus only share 594 orthologous genes, themselves sharing only 50% of identical residues in average. Despite this divergence, comparable to the maximal divergence exhibited by bacteria within the same division (e.g., gamma proteobacteria), Megavirus retained all of the genomic features unique to Mimivirus, in particular its genes encoding key-elements of the translation apparatus, a trademark of cellular organisms. Besides homologs to the four aminoacyl-tRNA synthetases (aaRS) encoded by Mimivirus, Megavirus added three additional ones, raising the total of known virus-encoded aaRS to seven: IleRS, TrpRS, AsnRS, ArgRS, CysRS, MetRS, TyrRS. This finding strongly suggests that large DNA viruses derived from an ancestral cellular genome by reductive evolution. The nature of this cellular ancestor remains hotly debated. SN - 1942-0889 UR - https://www.unboundmedicine.com/medline/citation/22482024/Genomics_of_Megavirus_and_the_elusive_fourth_domain_of_Life_ L2 - https://www.tandfonline.com/doi/full/10.4161/cib.18624 DB - PRIME DP - Unbound Medicine ER -
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