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[Expression and significance of CEACAM1 and HBx in HBV related hepatocellular carcinoma].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Apr; 28(4):410-2.XB

Abstract

AIM

To investigate the expression and clinical significance of CEACAM1 and HBx in HBV related hepatocellular carcinoma.

METHODS

The expression of CEACAM1 and HBx in 81 HBV related hepatocellular carcinoma were detected by immunohistochemistry, and the relationship with clinicopathological features was analyzed. The expression of CEACAM1 in the human normal hepatocyte cell line QZG, HepG2 and HepG2-X were detected by Western blot.

RESULTS

The positive rate of CEACAM1 and HBx in 81 HBV related hepatocellular carcinoma tissues were 71.60%(58/81) and 74.07%(60/81) respectively. The expression of CEACAM1 and HBx were correlated with portal vein invasion, nodal metastasis and TNM staging. The expression of CEACAM1 was negative correlated with HBx(r(s);=-0.310, P<0.01). CEACAM1 protein was significantly down regulated in HepG2-X than in HepG2-PC and human normal hepatocyte cell line QZG.

CONCLUSION

The higher expression of HBx and lower expression of CEACAM1 are correlated with invasion and metastasis of HBV related hepatocelular carcinoma, CEACAM1 may be a effect molecule in HBV related hepatocarcinogenesis.

Authors+Show Affiliations

Department of Digestion, The First Affiliated Hospital of Xi'an Medical University, Xi'an 710077, China. kaigeliu@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

22482415

Citation

Liu, Kai-Ge, et al. "[Expression and Significance of CEACAM1 and HBx in HBV Related Hepatocellular Carcinoma]." Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi = Chinese Journal of Cellular and Molecular Immunology, vol. 28, no. 4, 2012, pp. 410-2.
Liu KG, Xu GZ, Yao Y, et al. [Expression and significance of CEACAM1 and HBx in HBV related hepatocellular carcinoma]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012;28(4):410-2.
Liu, K. G., Xu, G. Z., Yao, Y., Wu, W., Li, Y. J., Ren, T. T., Xu, G. H., & Ye, L. (2012). [Expression and significance of CEACAM1 and HBx in HBV related hepatocellular carcinoma]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi = Chinese Journal of Cellular and Molecular Immunology, 28(4), 410-2.
Liu KG, et al. [Expression and Significance of CEACAM1 and HBx in HBV Related Hepatocellular Carcinoma]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012;28(4):410-2. PubMed PMID: 22482415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Expression and significance of CEACAM1 and HBx in HBV related hepatocellular carcinoma]. AU - Liu,Kai-Ge, AU - Xu,Gang-Zhu, AU - Yao,Yang, AU - Wu,Wei, AU - Li,Ya-Jun, AU - Ren,Ting-Ting, AU - Xu,Guang-Hua, AU - Ye,Lin, PY - 2012/4/10/entrez PY - 2012/4/10/pubmed PY - 2012/8/28/medline SP - 410 EP - 2 JF - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology JO - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi VL - 28 IS - 4 N2 - AIM: To investigate the expression and clinical significance of CEACAM1 and HBx in HBV related hepatocellular carcinoma. METHODS: The expression of CEACAM1 and HBx in 81 HBV related hepatocellular carcinoma were detected by immunohistochemistry, and the relationship with clinicopathological features was analyzed. The expression of CEACAM1 in the human normal hepatocyte cell line QZG, HepG2 and HepG2-X were detected by Western blot. RESULTS: The positive rate of CEACAM1 and HBx in 81 HBV related hepatocellular carcinoma tissues were 71.60%(58/81) and 74.07%(60/81) respectively. The expression of CEACAM1 and HBx were correlated with portal vein invasion, nodal metastasis and TNM staging. The expression of CEACAM1 was negative correlated with HBx(r(s);=-0.310, P<0.01). CEACAM1 protein was significantly down regulated in HepG2-X than in HepG2-PC and human normal hepatocyte cell line QZG. CONCLUSION: The higher expression of HBx and lower expression of CEACAM1 are correlated with invasion and metastasis of HBV related hepatocelular carcinoma, CEACAM1 may be a effect molecule in HBV related hepatocarcinogenesis. SN - 1007-8738 UR - https://www.unboundmedicine.com/medline/citation/22482415/[Expression_and_significance_of_CEACAM1_and_HBx_in_HBV_related_hepatocellular_carcinoma]_ L2 - https://medlineplus.gov/livercancer.html DB - PRIME DP - Unbound Medicine ER -