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Tau and tauopathies.

Abstract

Tauopathies are age-related neurodegenerative diseases that are characterized by the presence of aggregates of abnormally phosphorylated tau. As tau was originally discovered as a microtubule-associated protein, it has been hypothesized that neurodegeneration results from a loss of the ability of tau to associate with microtubules. However, tau has been found to have other functions aside from the promotion and stabilization of microtubule assembly. It is conceivable that such functions may be affected by the abnormal phosphorylation of tau and might have consequences for neuronal function or viability. This chapter provides an overview of tau structure, functions, and its involvement in neurodegenerative diseases.

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    MeSH

    Animals
    Cytoskeleton
    Humans
    Mice
    Models, Neurological
    Mutation
    Phosphorylation
    Protein Interaction Domains and Motifs
    Protein Isoforms
    Tauopathies
    Translational Medical Research
    tau Proteins

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    22482453