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Efficacy of 20-OH-ecdysone on hepatic key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats.
Phytomedicine. 2012 Jun 15; 19(8-9):725-9.P

Abstract

The aim of the present investigation was to evaluate the anti-diabetic activity of 20-OH-ecdysone on glucose metabolic key enzymes in control and streptozotocin induced diabetic rats. On oral administration of 20-OH-ecdysone at a dose of 5mg/kg body weight per day to diabetic rats for 30 days resulted in a significant decrease in the levels of plasma glucose, glycosylated hemoglobin (HbA1c) and an increase in the levels of insulin and hemoglobin. Administration of 20-OH-ecdysone showed significant increase in the levels of glycolytic enzyme (hexokinase) and hepatic shunt enzyme (glucose-6-phosphate dehydrogenase) whereas significant decrease in the levels of gluconeogenic enzymes (glucose-6-phosphatase and fructose-1,6-bisphosphatase) in diabetic treated rats. Furthermore, protection against body weight loss of diabetic animals also observed. This study indicates that the administration of 20-OH-ecdysone to diabetic rats resulted in alterations in the metabolism of glucose with subsequent reduction in plasma glucose levels. A comparison was made between the action of 20-OH-ecdysone and antidiabetic drug-glibenclamide. The effects produced by the 20-OH-ecdysone were comparable to that of glibenclamide.

Authors+Show Affiliations

Department of Medical Biochemistry, Dr ALM P-G, Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, Tamil Nadu 600113, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22484004

Citation

Sundaram, Ramalingam, et al. "Efficacy of 20-OH-ecdysone On Hepatic Key Enzymes of Carbohydrate Metabolism in Streptozotocin Induced Diabetic Rats." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 19, no. 8-9, 2012, pp. 725-9.
Sundaram R, Naresh R, Shanthi P, et al. Efficacy of 20-OH-ecdysone on hepatic key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats. Phytomedicine. 2012;19(8-9):725-9.
Sundaram, R., Naresh, R., Shanthi, P., & Sachdanandam, P. (2012). Efficacy of 20-OH-ecdysone on hepatic key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 19(8-9), 725-9. https://doi.org/10.1016/j.phymed.2012.02.019
Sundaram R, et al. Efficacy of 20-OH-ecdysone On Hepatic Key Enzymes of Carbohydrate Metabolism in Streptozotocin Induced Diabetic Rats. Phytomedicine. 2012 Jun 15;19(8-9):725-9. PubMed PMID: 22484004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of 20-OH-ecdysone on hepatic key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats. AU - Sundaram,Ramalingam, AU - Naresh,Rajendran, AU - Shanthi,Palanivelu, AU - Sachdanandam,Panchanatham, Y1 - 2012/04/06/ PY - 2011/10/20/received PY - 2012/02/02/revised PY - 2012/02/28/accepted PY - 2012/4/10/entrez PY - 2012/4/10/pubmed PY - 2012/12/10/medline SP - 725 EP - 9 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 19 IS - 8-9 N2 - The aim of the present investigation was to evaluate the anti-diabetic activity of 20-OH-ecdysone on glucose metabolic key enzymes in control and streptozotocin induced diabetic rats. On oral administration of 20-OH-ecdysone at a dose of 5mg/kg body weight per day to diabetic rats for 30 days resulted in a significant decrease in the levels of plasma glucose, glycosylated hemoglobin (HbA1c) and an increase in the levels of insulin and hemoglobin. Administration of 20-OH-ecdysone showed significant increase in the levels of glycolytic enzyme (hexokinase) and hepatic shunt enzyme (glucose-6-phosphate dehydrogenase) whereas significant decrease in the levels of gluconeogenic enzymes (glucose-6-phosphatase and fructose-1,6-bisphosphatase) in diabetic treated rats. Furthermore, protection against body weight loss of diabetic animals also observed. This study indicates that the administration of 20-OH-ecdysone to diabetic rats resulted in alterations in the metabolism of glucose with subsequent reduction in plasma glucose levels. A comparison was made between the action of 20-OH-ecdysone and antidiabetic drug-glibenclamide. The effects produced by the 20-OH-ecdysone were comparable to that of glibenclamide. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/22484004/Efficacy_of_20_OH_ecdysone_on_hepatic_key_enzymes_of_carbohydrate_metabolism_in_streptozotocin_induced_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(12)00083-9 DB - PRIME DP - Unbound Medicine ER -