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Impact of metabolic syndrome on the incidence of chronic kidney disease: a Chinese cohort study.
Nephrology (Carlton) 2012; 17(6):532-8N

Abstract

AIM

Metabolic syndrome (MetS) is a major culprit in cardiovascular disease and chronic kidney disease (CKD) in Western populations. We studied the longitudinal association between MetS and incident CKD in Chinese adults.

METHODS

A cohort study was conducted in a nationally representative sample of 4248 Chinese adults in Taiwan. The MetS was defined according to a unified criteria set by several major organizations and CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min per 1.73 m(2). Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) adjusted for sex, age, body mass index (BMI) and serum levels of total cholesterol.

RESULTS

The prevalence of MetS among participants at baseline recruitment was 15.0% (637/4248). During a median follow-up period of 5.40 years, 208 subjects (4.9%) developed CKD. The multivariate-adjusted HR of CKD in participants with MetS compared with those without was 1.42 (95% CI = 1.03, 1.73). Additionally, there was a significantly graded relationship between the number of the MetS components and risk of CKD. Further, the relation between MetS and incident CKD was more robust in subjects with BMI >27.5 kg/m(2) than in those with lower BMI.

CONCLUSION

The results suggest that the presence of MetS was significantly associated with increased risk of incident CKD in a Chinese population. These findings warrant future studies to test the impact of preventing and treating MetS on the reduction of the occurrence of CKD.

Authors+Show Affiliations

Department of Health Business Administration, Meiho University, Pingtung County, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22487238

Citation

Yang, Tsan, et al. "Impact of Metabolic Syndrome On the Incidence of Chronic Kidney Disease: a Chinese Cohort Study." Nephrology (Carlton, Vic.), vol. 17, no. 6, 2012, pp. 532-8.
Yang T, Chu CH, Hsu CH, et al. Impact of metabolic syndrome on the incidence of chronic kidney disease: a Chinese cohort study. Nephrology (Carlton). 2012;17(6):532-8.
Yang, T., Chu, C. H., Hsu, C. H., Hsieh, P. C., Chung, T. C., Bai, C. H., ... Sun, C. A. (2012). Impact of metabolic syndrome on the incidence of chronic kidney disease: a Chinese cohort study. Nephrology (Carlton, Vic.), 17(6), pp. 532-8. doi:10.1111/j.1440-1797.2012.01607.x.
Yang T, et al. Impact of Metabolic Syndrome On the Incidence of Chronic Kidney Disease: a Chinese Cohort Study. Nephrology (Carlton). 2012;17(6):532-8. PubMed PMID: 22487238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of metabolic syndrome on the incidence of chronic kidney disease: a Chinese cohort study. AU - Yang,Tsan, AU - Chu,Chi-Hong, AU - Hsu,Chih-Hsung, AU - Hsieh,Po-Chien, AU - Chung,Tieh-Chi, AU - Bai,Chyi-Huey, AU - You,San-Lin, AU - Hwang,Lee-Ching, AU - Lin,Chih-Ming, AU - Sun,Chien-An, PY - 2012/4/11/entrez PY - 2012/4/11/pubmed PY - 2012/12/10/medline SP - 532 EP - 8 JF - Nephrology (Carlton, Vic.) JO - Nephrology (Carlton) VL - 17 IS - 6 N2 - AIM: Metabolic syndrome (MetS) is a major culprit in cardiovascular disease and chronic kidney disease (CKD) in Western populations. We studied the longitudinal association between MetS and incident CKD in Chinese adults. METHODS: A cohort study was conducted in a nationally representative sample of 4248 Chinese adults in Taiwan. The MetS was defined according to a unified criteria set by several major organizations and CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min per 1.73 m(2). Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) adjusted for sex, age, body mass index (BMI) and serum levels of total cholesterol. RESULTS: The prevalence of MetS among participants at baseline recruitment was 15.0% (637/4248). During a median follow-up period of 5.40 years, 208 subjects (4.9%) developed CKD. The multivariate-adjusted HR of CKD in participants with MetS compared with those without was 1.42 (95% CI = 1.03, 1.73). Additionally, there was a significantly graded relationship between the number of the MetS components and risk of CKD. Further, the relation between MetS and incident CKD was more robust in subjects with BMI >27.5 kg/m(2) than in those with lower BMI. CONCLUSION: The results suggest that the presence of MetS was significantly associated with increased risk of incident CKD in a Chinese population. These findings warrant future studies to test the impact of preventing and treating MetS on the reduction of the occurrence of CKD. SN - 1440-1797 UR - https://www.unboundmedicine.com/medline/citation/22487238/Impact_of_metabolic_syndrome_on_the_incidence_of_chronic_kidney_disease:_a_Chinese_cohort_study_ L2 - https://doi.org/10.1111/j.1440-1797.2012.01607.x DB - PRIME DP - Unbound Medicine ER -