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The sixth nationwide epidemiological survey of chronic pancreatitis in Japan.
Pancreatology 2012 Mar-Apr; 12(2):79-84P

Abstract

OBJECTIVES

A nationwide survey was conducted to clarify the epidemiological features of patients with chronic pancreatitis (CP) in Japan.

METHODS

Two sequential surveys were conducted. In the first survey, both the prevalence and incidence of CP in Japan in 2007 were estimated by a questionnaire, which was mailed to 3027 randomly chosen Japanese facilities. In the second survey, the second questionnaire was then mailed to 1110 facilities selected by the first survey to clarify the clinicoepidemiological features of the patients.

RESULTS

The estimated annual prevalence of CP was 36.9 per 100,000; 53.2 in males and 21.2 in females. The estimated annual incidence was 11.9 per 100,000. The prevalence and the incidence of CP gradually increased in Japan as compared to former surveys. The sex ratio (male/female) of definitive and probable CP patients was 4.5, with a mean age of 59.4 years; 59.2 years in males and 60.2 years in females. Alcoholic (69.7%) was most the common and idiopathic (21.0%) was the second most common cause of CP. The proportion of alcoholic CP increased as compared to the 55.5% found in 1994. The clinical features of overall Japanese patients with CP were: abdominal pain (60.6%), malabsorbtion (12.2%), diabetes mellitus (39.7%) and pancreatolithiasis (75.7%). Alcoholic patients were characterized by high morbidity as compared to nonalcoholic patients: abdominal pain (alcoholic 65.0% vs nonalcoholic 53.0%, p < 0.0001), diabetes mellitus (44.8% vs 31.4%, p < 0.0001) and pancreatolithiasis (84.0% vs 60.8%, p < 0.0001).

CONCLUSION

The prevalence and the incidence of CP, especially alcoholic CP, have been increasing in Japan.

Authors+Show Affiliations

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-cho, Aoba-ku, Sendai City, Miyagi 980-8574, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22487515

Citation

Hirota, Morihisa, et al. "The Sixth Nationwide Epidemiological Survey of Chronic Pancreatitis in Japan." Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.], vol. 12, no. 2, 2012, pp. 79-84.
Hirota M, Shimosegawa T, Masamune A, et al. The sixth nationwide epidemiological survey of chronic pancreatitis in Japan. Pancreatology. 2012;12(2):79-84.
Hirota, M., Shimosegawa, T., Masamune, A., Kikuta, K., Kume, K., Hamada, S., ... Kuriyama, S. (2012). The sixth nationwide epidemiological survey of chronic pancreatitis in Japan. Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.], 12(2), pp. 79-84. doi:10.1016/j.pan.2012.02.005.
Hirota M, et al. The Sixth Nationwide Epidemiological Survey of Chronic Pancreatitis in Japan. Pancreatology. 2012;12(2):79-84. PubMed PMID: 22487515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The sixth nationwide epidemiological survey of chronic pancreatitis in Japan. AU - Hirota,Morihisa, AU - Shimosegawa,Tooru, AU - Masamune,Atsushi, AU - Kikuta,Kazuhiro, AU - Kume,Kiyoshi, AU - Hamada,Shin, AU - Kihara,Yasuyuki, AU - Satoh,Akihiko, AU - Kimura,Kenji, AU - Tsuji,Ichiro, AU - Kuriyama,Shinichi, AU - ,, Y1 - 2012/02/16/ PY - 2011/12/20/received PY - 2012/02/09/revised PY - 2012/02/10/accepted PY - 2012/4/11/entrez PY - 2012/4/11/pubmed PY - 2012/12/10/medline SP - 79 EP - 84 JF - Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] JO - Pancreatology VL - 12 IS - 2 N2 - OBJECTIVES: A nationwide survey was conducted to clarify the epidemiological features of patients with chronic pancreatitis (CP) in Japan. METHODS: Two sequential surveys were conducted. In the first survey, both the prevalence and incidence of CP in Japan in 2007 were estimated by a questionnaire, which was mailed to 3027 randomly chosen Japanese facilities. In the second survey, the second questionnaire was then mailed to 1110 facilities selected by the first survey to clarify the clinicoepidemiological features of the patients. RESULTS: The estimated annual prevalence of CP was 36.9 per 100,000; 53.2 in males and 21.2 in females. The estimated annual incidence was 11.9 per 100,000. The prevalence and the incidence of CP gradually increased in Japan as compared to former surveys. The sex ratio (male/female) of definitive and probable CP patients was 4.5, with a mean age of 59.4 years; 59.2 years in males and 60.2 years in females. Alcoholic (69.7%) was most the common and idiopathic (21.0%) was the second most common cause of CP. The proportion of alcoholic CP increased as compared to the 55.5% found in 1994. The clinical features of overall Japanese patients with CP were: abdominal pain (60.6%), malabsorbtion (12.2%), diabetes mellitus (39.7%) and pancreatolithiasis (75.7%). Alcoholic patients were characterized by high morbidity as compared to nonalcoholic patients: abdominal pain (alcoholic 65.0% vs nonalcoholic 53.0%, p < 0.0001), diabetes mellitus (44.8% vs 31.4%, p < 0.0001) and pancreatolithiasis (84.0% vs 60.8%, p < 0.0001). CONCLUSION: The prevalence and the incidence of CP, especially alcoholic CP, have been increasing in Japan. SN - 1424-3911 UR - https://www.unboundmedicine.com/medline/citation/22487515/The_sixth_nationwide_epidemiological_survey_of_chronic_pancreatitis_in_Japan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1424-3903(12)00038-5 DB - PRIME DP - Unbound Medicine ER -