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[Association study of brain-derived neurotrophic factor Val66Met polymorphism and clinical characteristics of first episode schizophrenia].

Abstract

OBJECTIVE

To assess the association between brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism and clinical characteristics of first episode schizophrenia in a Chinese Han population.

METHODS

Genotyping of BDNF Val66Met polymorphism was carried out for 135 schizophrenic patients and 483 healthy controls with TaqMan probe technology. The patients' psychotic symptoms were assessed using the positive and negative syndrome scale (PANSS).

RESULTS

A significant difference was found in genotype distribution and allelic frequency of the Val66Met polymorphism between the two groups (P< 0.01). In patients, Met homozygotes had a significantly higher score in anxiety/depression factor, cognitive factor and total score of PANSS than Val carriers.

CONCLUSION

BDNF gene Val66Met polymorphism is associated with the pathogenesis of schizophrenia. The Met/Met genotype of BDNF Val66Met variant may be a risk factor for symptoms in first episode schizophrenia patients.

Authors+Show Affiliations

School of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

22487823

Citation

Sun, Meng-meng, et al. "[Association Study of Brain-derived Neurotrophic Factor Val66Met Polymorphism and Clinical Characteristics of First Episode Schizophrenia]." Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, vol. 29, no. 2, 2012, pp. 155-8.
Sun MM, Liu LF, Yang LM, et al. [Association study of brain-derived neurotrophic factor Val66Met polymorphism and clinical characteristics of first episode schizophrenia]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012;29(2):155-8.
Sun, M. M., Liu, L. F., Yang, L. M., Wang, Y., Cui, K. Y., Wang, L. N., ... Wang, R. Z. (2012). [Association study of brain-derived neurotrophic factor Val66Met polymorphism and clinical characteristics of first episode schizophrenia]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, 29(2), pp. 155-8. doi:10.3760/cma.j.issn.1003-9406.2012.02.008.
Sun MM, et al. [Association Study of Brain-derived Neurotrophic Factor Val66Met Polymorphism and Clinical Characteristics of First Episode Schizophrenia]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012;29(2):155-8. PubMed PMID: 22487823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Association study of brain-derived neurotrophic factor Val66Met polymorphism and clinical characteristics of first episode schizophrenia]. AU - Sun,Meng-meng, AU - Liu,Lan-fen, AU - Yang,Li-min, AU - Wang,Yan, AU - Cui,Kai-yan, AU - Wang,Li-na, AU - Li,Cui-luan, AU - Qiao,Dong-dong, AU - Wang,Ru-zhan, PY - 2012/4/11/entrez PY - 2012/4/11/pubmed PY - 2012/7/18/medline SP - 155 EP - 8 JF - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics JO - Zhonghua Yi Xue Yi Chuan Xue Za Zhi VL - 29 IS - 2 N2 - OBJECTIVE: To assess the association between brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism and clinical characteristics of first episode schizophrenia in a Chinese Han population. METHODS: Genotyping of BDNF Val66Met polymorphism was carried out for 135 schizophrenic patients and 483 healthy controls with TaqMan probe technology. The patients' psychotic symptoms were assessed using the positive and negative syndrome scale (PANSS). RESULTS: A significant difference was found in genotype distribution and allelic frequency of the Val66Met polymorphism between the two groups (P< 0.01). In patients, Met homozygotes had a significantly higher score in anxiety/depression factor, cognitive factor and total score of PANSS than Val carriers. CONCLUSION: BDNF gene Val66Met polymorphism is associated with the pathogenesis of schizophrenia. The Met/Met genotype of BDNF Val66Met variant may be a risk factor for symptoms in first episode schizophrenia patients. SN - 1003-9406 UR - https://www.unboundmedicine.com/medline/citation/22487823/[Association_study_of_brain_derived_neurotrophic_factor_Val66Met_polymorphism_and_clinical_characteristics_of_first_episode_schizophrenia]_ L2 - http://www.diseaseinfosearch.org/result/6442 DB - PRIME DP - Unbound Medicine ER -