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[Class IgA antigliadin antibodies and monitoring of compliance to gluten-free diet in celiac disease].
Ann Ital Med Int. 1990 Apr-Jun; 5(2):112-7.AI

Abstract

Antibodies to gliadin (AGA), detected by ELISA, were found in the sera of 37 (88%) of 42 patients with untreated adult celiac disease. IgG class AGA showed a higher sensitivity for the diagnosis of celiac disease than IgA AGA, but, while IgA AGA had a specificity of 100% for celiac disease, false positives of IgG class were present in 19% of 37 patients with ulcerative colitis and in 27% of 26 patients with Crohn's disease. Twenty-eight out of our 42 adult celiac patients were tested after 6-12 months of gluten free diet: IgG AGA persisted in 43% of them showing antibody titres lower than those observed in untreated celiac disease. IgA AGA became negative after gluten withdrawal and there was regrowth of jejunal villi in all but 2 adult celiac patients (7%), who continued to present IgA AGA positivity and subtotal villous atrophy. These 2 patients did not comply to the gluten free diet. Our study confirms the specificity of IgA AGA for untreated celiac disease and emphasizes their usefulness in monitoring the compliance with gluten free diet in adult celiac disease.

Authors+Show Affiliations

Istituto di Clinica, Medica Generale e Terapia Medica, Università degli Studi di Bologna.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

ita

PubMed ID

2248858

Citation

Volta, U, et al. "[Class IgA Antigliadin Antibodies and Monitoring of Compliance to Gluten-free Diet in Celiac Disease]." Annali Italiani Di Medicina Interna : Organo Ufficiale Della Societa Italiana Di Medicina Interna, vol. 5, no. 2, 1990, pp. 112-7.
Volta U, Molinaro N, Fratangelo D, et al. [Class IgA antigliadin antibodies and monitoring of compliance to gluten-free diet in celiac disease]. Ann Ital Med Int. 1990;5(2):112-7.
Volta, U., Molinaro, N., Fratangelo, D., & Bianco Bianchi, F. (1990). [Class IgA antigliadin antibodies and monitoring of compliance to gluten-free diet in celiac disease]. Annali Italiani Di Medicina Interna : Organo Ufficiale Della Societa Italiana Di Medicina Interna, 5(2), 112-7.
Volta U, et al. [Class IgA Antigliadin Antibodies and Monitoring of Compliance to Gluten-free Diet in Celiac Disease]. Ann Ital Med Int. 1990 Apr-Jun;5(2):112-7. PubMed PMID: 2248858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Class IgA antigliadin antibodies and monitoring of compliance to gluten-free diet in celiac disease]. AU - Volta,U, AU - Molinaro,N, AU - Fratangelo,D, AU - Bianco Bianchi,F, PY - 1990/4/1/pubmed PY - 1990/4/1/medline PY - 1990/4/1/entrez SP - 112 EP - 7 JF - Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna JO - Ann Ital Med Int VL - 5 IS - 2 N2 - Antibodies to gliadin (AGA), detected by ELISA, were found in the sera of 37 (88%) of 42 patients with untreated adult celiac disease. IgG class AGA showed a higher sensitivity for the diagnosis of celiac disease than IgA AGA, but, while IgA AGA had a specificity of 100% for celiac disease, false positives of IgG class were present in 19% of 37 patients with ulcerative colitis and in 27% of 26 patients with Crohn's disease. Twenty-eight out of our 42 adult celiac patients were tested after 6-12 months of gluten free diet: IgG AGA persisted in 43% of them showing antibody titres lower than those observed in untreated celiac disease. IgA AGA became negative after gluten withdrawal and there was regrowth of jejunal villi in all but 2 adult celiac patients (7%), who continued to present IgA AGA positivity and subtotal villous atrophy. These 2 patients did not comply to the gluten free diet. Our study confirms the specificity of IgA AGA for untreated celiac disease and emphasizes their usefulness in monitoring the compliance with gluten free diet in adult celiac disease. SN - 0393-9340 UR - https://www.unboundmedicine.com/medline/citation/2248858/[Class_IgA_antigliadin_antibodies_and_monitoring_of_compliance_to_gluten_free_diet_in_celiac_disease]_ DB - PRIME DP - Unbound Medicine ER -