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Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal squamous cell carcinoma, with emphasis on smoking, protein p16(INK4a) expression, and HPV status.
Neoplasma 2012; 59(4):398-408N

Abstract

The aim of this study is to evaluate the biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinoma, with emphasis on smoking, protein p16(INK4a) (p16) expression, and human papillomavirus (HPV) status.The study sample consisted of 48 patients with OSCC and 44 patients with OPSCC. Half of the patients were nonsmokers and the other half were gender-, age- and tumor localization-matched smokers. p16 expression was detected in 17/48 (35 %) OSCCs and in 36/44 (82 %) OPSCCs and HPV DNA was present in 7/48 (15 %) OSCCs and in 35/44 (80 %) OPSCCs. The sensitivity and specificity of p16 expression for HPV DNA presence were 0.74 and 0.88, respectively. The OPSCCs were more frequently basaloid (p < 0.001) while the OSCCs were more frequently conventional (p < 0.000001). The OSCCs were more likely to recur locally and to be the cause of death (p = 0.009 in both parameters).The HPV-positive tumors were more frequently localized in oropharynx, were basaloid SCCs and were p16- and HPV-positive (p < 0.000001 in all 4 parameters). The HPV-negative tumors were more frequently localized in oral cavity (p < 0.000001), more frequently asociated with local, regional and locoregional recurence (p = 0.011, p = 0.019 and p = 0.030, respectively) and with tumor-related death (p = 0.003). There was no significant difference with regard to smoking history (p > 0.05). The survival of patients with HPV-positive tumors was significantly longer (median 112 months; 95% CI 54 - 112 months) than that of patients with HPV-negative tumors (median 17 months; 95% CI 12 - 39 months) (p < 0.001). The HPV status of OSCC/OPSCC is an important biological and prognostic parameter and should be examined in all cases, using PCR or immunohistochemical detection of surrogate marker p16. Smoking itself does not seem to be an important prognostic factor.

Authors+Show Affiliations

The Fingerland Department of Pathology, Charles University Faculty of Medicine and Faculty Hospital in Hradec Kralove, Czech Republic. lacoj@lfhk.cuni.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22489695

Citation

Laco, J, et al. "Biologic Importance and Prognostic Significance of Selected Clinicopathological Parameters in Patients With Oral and Oropharyngeal Squamous Cell Carcinoma, With Emphasis On Smoking, Protein p16(INK4a) Expression, and HPV Status." Neoplasma, vol. 59, no. 4, 2012, pp. 398-408.
Laco J, Nekvindova J, Novakova V, et al. Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal squamous cell carcinoma, with emphasis on smoking, protein p16(INK4a) expression, and HPV status. Neoplasma. 2012;59(4):398-408.
Laco, J., Nekvindova, J., Novakova, V., Celakovsky, P., Dolezalova, H., Tucek, L., ... Ryska, A. (2012). Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal squamous cell carcinoma, with emphasis on smoking, protein p16(INK4a) expression, and HPV status. Neoplasma, 59(4), pp. 398-408. doi:10.4149/neo_2012_052.
Laco J, et al. Biologic Importance and Prognostic Significance of Selected Clinicopathological Parameters in Patients With Oral and Oropharyngeal Squamous Cell Carcinoma, With Emphasis On Smoking, Protein p16(INK4a) Expression, and HPV Status. Neoplasma. 2012;59(4):398-408. PubMed PMID: 22489695.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal squamous cell carcinoma, with emphasis on smoking, protein p16(INK4a) expression, and HPV status. AU - Laco,J, AU - Nekvindova,J, AU - Novakova,V, AU - Celakovsky,P, AU - Dolezalova,H, AU - Tucek,L, AU - Vosmikova,H, AU - Vosmik,M, AU - Neskudlova,T, AU - Cermakova,E, AU - Hacova,M, AU - Sobande,F A, AU - Ryska,A, PY - 2012/4/12/entrez PY - 2012/4/12/pubmed PY - 2012/8/8/medline SP - 398 EP - 408 JF - Neoplasma JO - Neoplasma VL - 59 IS - 4 N2 - The aim of this study is to evaluate the biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinoma, with emphasis on smoking, protein p16(INK4a) (p16) expression, and human papillomavirus (HPV) status.The study sample consisted of 48 patients with OSCC and 44 patients with OPSCC. Half of the patients were nonsmokers and the other half were gender-, age- and tumor localization-matched smokers. p16 expression was detected in 17/48 (35 %) OSCCs and in 36/44 (82 %) OPSCCs and HPV DNA was present in 7/48 (15 %) OSCCs and in 35/44 (80 %) OPSCCs. The sensitivity and specificity of p16 expression for HPV DNA presence were 0.74 and 0.88, respectively. The OPSCCs were more frequently basaloid (p < 0.001) while the OSCCs were more frequently conventional (p < 0.000001). The OSCCs were more likely to recur locally and to be the cause of death (p = 0.009 in both parameters).The HPV-positive tumors were more frequently localized in oropharynx, were basaloid SCCs and were p16- and HPV-positive (p < 0.000001 in all 4 parameters). The HPV-negative tumors were more frequently localized in oral cavity (p < 0.000001), more frequently asociated with local, regional and locoregional recurence (p = 0.011, p = 0.019 and p = 0.030, respectively) and with tumor-related death (p = 0.003). There was no significant difference with regard to smoking history (p > 0.05). The survival of patients with HPV-positive tumors was significantly longer (median 112 months; 95% CI 54 - 112 months) than that of patients with HPV-negative tumors (median 17 months; 95% CI 12 - 39 months) (p < 0.001). The HPV status of OSCC/OPSCC is an important biological and prognostic parameter and should be examined in all cases, using PCR or immunohistochemical detection of surrogate marker p16. Smoking itself does not seem to be an important prognostic factor. SN - 0028-2685 UR - https://www.unboundmedicine.com/medline/citation/22489695/Biologic_importance_and_prognostic_significance_of_selected_clinicopathological_parameters_in_patients_with_oral_and_oropharyngeal_squamous_cell_carcinoma_with_emphasis_on_smoking_protein_p16_INK4a__expression_and_HPV_status_ L2 - https://dx.doi.org/10.4149/neo_2012_052 DB - PRIME DP - Unbound Medicine ER -