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Effect of a tomato-rich diet on markers of cardiovascular disease risk in moderately overweight, disease-free, middle-aged adults: a randomized controlled trial.
Am J Clin Nutr. 2012 May; 95(5):1013-22.AJ

Abstract

BACKGROUND

Cardiovascular disease (CVD) is a major cause of mortality in the United Kingdom. Epidemiologic studies suggest that consumption of tomato-based foods may lower CVD risk. Such potential benefits have been ascribed in part to high concentrations of lycopene in the tomatoes. However, these findings have not yet been validated by comprehensive intervention trials.

OBJECTIVE

The aim of this study was to conduct a single-blind, randomized controlled intervention trial with healthy middle-aged volunteers to assess whether the consumption of tomato-based foods affects recognized biomarkers of CVD risk.

DESIGN

After a 4-wk run-in period with a low-tomato diet, 225 volunteers (94 men and 131 women) aged 40-65 y were randomly assigned into 1 of 3 dietary intervention groups and asked to consume a control diet (low in tomato-based foods), a high-tomato-based diet, or a control diet supplemented with lycopene capsules (10 mg/d) for 12 wk. Blood samples were collected at baseline, at 6 wk, and after the intervention and were analyzed for carotenoid and lipid profiles and inflammatory markers. Blood pressure, weight, and arterial stiffness were also measured. Dietary intake was also determined during the intervention.

RESULTS

None of the systemic markers (inflammatory markers, markers of insulin resistance and sensitivity) changed significantly after the dietary intervention. Moreover, lipid concentrations and arterial stiffness were also unaffected by the interventions.

CONCLUSION

These data indicate that a relatively high daily consumption of tomato-based products (equivalent to 32-50 mg lycopene/d) or lycopene supplements (10 mg/d) is ineffective at reducing conventional CVD risk markers in moderately overweight, healthy, middle-aged individuals. This trial was registered at isrctn.org as ISRCTN34203810.

Authors+Show Affiliations

Division of Applied Medicine, University of Aberdeen, Aberdeen, United Kingdom. f.thies@abdn.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22492370

Citation

Thies, Frank, et al. "Effect of a Tomato-rich Diet On Markers of Cardiovascular Disease Risk in Moderately Overweight, Disease-free, Middle-aged Adults: a Randomized Controlled Trial." The American Journal of Clinical Nutrition, vol. 95, no. 5, 2012, pp. 1013-22.
Thies F, Masson LF, Rudd A, et al. Effect of a tomato-rich diet on markers of cardiovascular disease risk in moderately overweight, disease-free, middle-aged adults: a randomized controlled trial. Am J Clin Nutr. 2012;95(5):1013-22.
Thies, F., Masson, L. F., Rudd, A., Vaughan, N., Tsang, C., Brittenden, J., Simpson, W. G., Duthie, S., Horgan, G. W., & Duthie, G. (2012). Effect of a tomato-rich diet on markers of cardiovascular disease risk in moderately overweight, disease-free, middle-aged adults: a randomized controlled trial. The American Journal of Clinical Nutrition, 95(5), 1013-22. https://doi.org/10.3945/ajcn.111.026286
Thies F, et al. Effect of a Tomato-rich Diet On Markers of Cardiovascular Disease Risk in Moderately Overweight, Disease-free, Middle-aged Adults: a Randomized Controlled Trial. Am J Clin Nutr. 2012;95(5):1013-22. PubMed PMID: 22492370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a tomato-rich diet on markers of cardiovascular disease risk in moderately overweight, disease-free, middle-aged adults: a randomized controlled trial. AU - Thies,Frank, AU - Masson,Lindsey F, AU - Rudd,Amelia, AU - Vaughan,Nicholas, AU - Tsang,Catherine, AU - Brittenden,Julie, AU - Simpson,William G, AU - Duthie,Susan, AU - Horgan,Graham W, AU - Duthie,Garry, Y1 - 2012/04/04/ PY - 2012/4/12/entrez PY - 2012/4/12/pubmed PY - 2012/6/15/medline SP - 1013 EP - 22 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 95 IS - 5 N2 - BACKGROUND: Cardiovascular disease (CVD) is a major cause of mortality in the United Kingdom. Epidemiologic studies suggest that consumption of tomato-based foods may lower CVD risk. Such potential benefits have been ascribed in part to high concentrations of lycopene in the tomatoes. However, these findings have not yet been validated by comprehensive intervention trials. OBJECTIVE: The aim of this study was to conduct a single-blind, randomized controlled intervention trial with healthy middle-aged volunteers to assess whether the consumption of tomato-based foods affects recognized biomarkers of CVD risk. DESIGN: After a 4-wk run-in period with a low-tomato diet, 225 volunteers (94 men and 131 women) aged 40-65 y were randomly assigned into 1 of 3 dietary intervention groups and asked to consume a control diet (low in tomato-based foods), a high-tomato-based diet, or a control diet supplemented with lycopene capsules (10 mg/d) for 12 wk. Blood samples were collected at baseline, at 6 wk, and after the intervention and were analyzed for carotenoid and lipid profiles and inflammatory markers. Blood pressure, weight, and arterial stiffness were also measured. Dietary intake was also determined during the intervention. RESULTS: None of the systemic markers (inflammatory markers, markers of insulin resistance and sensitivity) changed significantly after the dietary intervention. Moreover, lipid concentrations and arterial stiffness were also unaffected by the interventions. CONCLUSION: These data indicate that a relatively high daily consumption of tomato-based products (equivalent to 32-50 mg lycopene/d) or lycopene supplements (10 mg/d) is ineffective at reducing conventional CVD risk markers in moderately overweight, healthy, middle-aged individuals. This trial was registered at isrctn.org as ISRCTN34203810. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22492370/Effect_of_a_tomato_rich_diet_on_markers_of_cardiovascular_disease_risk_in_moderately_overweight_disease_free_middle_aged_adults:_a_randomized_controlled_trial_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.026286 DB - PRIME DP - Unbound Medicine ER -