Tags

Type your tag names separated by a space and hit enter

Anaphylaxis to pork kidney is related to IgE antibodies specific for galactose-alpha-1,3-galactose.
Allergy. 2012 May; 67(5):699-704.A

Abstract

BACKGROUND

Carbohydrate-specific IgE antibodies present on nonprimate mammalian proteins were incriminated recently in delayed meat anaphylaxis. The aim of this study was to explore whether anaphylaxis to mammalian kidney is also associated with galactose-α-1,3-galactose (αGal)-specific IgE.

METHODS

Fourteen patients with anaphylaxis to pork or beef kidney underwent prick tests to meat and kidney. Some patients also underwent skin tests to Erbitux(®) (cetuximab). IgE antibodies to αGal, swine urine proteins, beef and pork meat, serum albumin proteins, cat, and rFel d 1 were measured by ImmunoCAP(®). The αGal levels were estimated in meats and kidney by ELISA inhibition assay. Cross-reactivity between αGal and pork kidney was studied with the ImmunoCAP(®) inhibition assay.

RESULTS

Among the 14 patients, 12 presented with anaphylactic shock. Reactions occurred within 2 h from exposure in 67% of patients. Associated risk factors were observed in 10 cases, and alcohol was the main cofactor. Three patients underwent an oral challenge to pork kidney, and anaphylaxis occurred after ingestion of small quantities (1-2 g). Prick tests to kidney were positive in 54% of patients. All tested patients showed positive skin tests to Erbitux(®). All patients tested positive for IgE to αGal, with levels ranging from 0.4 to 294 kU/l. IgE binding to αGal was inhibited by raw pork kidney extract (mean, 77%; range, 55-87%), which showed a high amount of αGal determinants.

CONCLUSIONS

Pork or beef kidney anaphylaxis is related to αGal IgE. Its peculiar severity could be due to an elevated content of αGal epitopes in kidney.

Authors+Show Affiliations

Internal Medicine, Clinical Immunology and Allergy, University Hospital, Nancy, France. morisset.martine@chl.luNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22494361

Citation

Morisset, M, et al. "Anaphylaxis to Pork Kidney Is Related to IgE Antibodies Specific for Galactose-alpha-1,3-galactose." Allergy, vol. 67, no. 5, 2012, pp. 699-704.
Morisset M, Richard C, Astier C, et al. Anaphylaxis to pork kidney is related to IgE antibodies specific for galactose-alpha-1,3-galactose. Allergy. 2012;67(5):699-704.
Morisset, M., Richard, C., Astier, C., Jacquenet, S., Croizier, A., Beaudouin, E., Cordebar, V., Morel-Codreanu, F., Petit, N., Moneret-Vautrin, D. A., & Kanny, G. (2012). Anaphylaxis to pork kidney is related to IgE antibodies specific for galactose-alpha-1,3-galactose. Allergy, 67(5), 699-704. https://doi.org/10.1111/j.1398-9995.2012.02799.x
Morisset M, et al. Anaphylaxis to Pork Kidney Is Related to IgE Antibodies Specific for Galactose-alpha-1,3-galactose. Allergy. 2012;67(5):699-704. PubMed PMID: 22494361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anaphylaxis to pork kidney is related to IgE antibodies specific for galactose-alpha-1,3-galactose. AU - Morisset,M, AU - Richard,C, AU - Astier,C, AU - Jacquenet,S, AU - Croizier,A, AU - Beaudouin,E, AU - Cordebar,V, AU - Morel-Codreanu,F, AU - Petit,N, AU - Moneret-Vautrin,D A, AU - Kanny,G, PY - 2012/4/13/entrez PY - 2012/4/13/pubmed PY - 2012/8/8/medline SP - 699 EP - 704 JF - Allergy JO - Allergy VL - 67 IS - 5 N2 - BACKGROUND: Carbohydrate-specific IgE antibodies present on nonprimate mammalian proteins were incriminated recently in delayed meat anaphylaxis. The aim of this study was to explore whether anaphylaxis to mammalian kidney is also associated with galactose-α-1,3-galactose (αGal)-specific IgE. METHODS: Fourteen patients with anaphylaxis to pork or beef kidney underwent prick tests to meat and kidney. Some patients also underwent skin tests to Erbitux(®) (cetuximab). IgE antibodies to αGal, swine urine proteins, beef and pork meat, serum albumin proteins, cat, and rFel d 1 were measured by ImmunoCAP(®). The αGal levels were estimated in meats and kidney by ELISA inhibition assay. Cross-reactivity between αGal and pork kidney was studied with the ImmunoCAP(®) inhibition assay. RESULTS: Among the 14 patients, 12 presented with anaphylactic shock. Reactions occurred within 2 h from exposure in 67% of patients. Associated risk factors were observed in 10 cases, and alcohol was the main cofactor. Three patients underwent an oral challenge to pork kidney, and anaphylaxis occurred after ingestion of small quantities (1-2 g). Prick tests to kidney were positive in 54% of patients. All tested patients showed positive skin tests to Erbitux(®). All patients tested positive for IgE to αGal, with levels ranging from 0.4 to 294 kU/l. IgE binding to αGal was inhibited by raw pork kidney extract (mean, 77%; range, 55-87%), which showed a high amount of αGal determinants. CONCLUSIONS: Pork or beef kidney anaphylaxis is related to αGal IgE. Its peculiar severity could be due to an elevated content of αGal epitopes in kidney. SN - 1398-9995 UR - https://www.unboundmedicine.com/medline/citation/22494361/Anaphylaxis_to_pork_kidney_is_related_to_IgE_antibodies_specific_for_galactose_alpha_13_galactose_ L2 - https://doi.org/10.1111/j.1398-9995.2012.02799.x DB - PRIME DP - Unbound Medicine ER -