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Hospitalizations associated with influenza and respiratory syncytial virus in the United States, 1993-2008.
Clin Infect Dis 2012; 54(10):1427-36CI

Abstract

BACKGROUND

Age-specific comparisons of influenza and respiratory syncytial virus (RSV) hospitalization rates can inform prevention efforts, including vaccine development plans. Previous US studies have not estimated jointly the burden of these viruses using similar data sources and over many seasons.

METHODS

We estimated influenza and RSV hospitalizations in 5 age categories (<1, 1-4, 5-49, 50-64, and ≥65 years) with data for 13 states from 1993-1994 through 2007-2008. For each state and age group, we estimated the contribution of influenza and RSV to hospitalizations for respiratory and circulatory disease by using negative binomial regression models that incorporated weekly influenza and RSV surveillance data as covariates.

RESULTS

Mean rates of influenza and RSV hospitalizations were 63.5 (95% confidence interval [CI], 37.5-237) and 55.3 (95% CI, 44.4-107) per 100000 person-years, respectively. The highest hospitalization rates for influenza were among persons aged ≥65 years (309/100000; 95% CI, 186-1100) and those aged <1 year (151/100000; 95% CI, 151-660). For RSV, children aged <1 year had the highest hospitalization rate (2350/100000; 95% CI, 2220-2520) followed by those aged 1-4 years (178/100000; 95% CI, 155-230). Age-standardized annual rates per 100000 person-years varied substantially for influenza (33-100) but less for RSV (42-77).

CONCLUSIONS

Overall US hospitalization rates for influenza and RSV are similar; however, their age-specific burdens differ dramatically. Our estimates are consistent with those from previous studies focusing either on influenza or RSV. Our approach provides robust national comparisons of hospitalizations associated with these 2 viral respiratory pathogens by age group and over time.

Authors+Show Affiliations

Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

22495079

Citation

Zhou, Hong, et al. "Hospitalizations Associated With Influenza and Respiratory Syncytial Virus in the United States, 1993-2008." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 54, no. 10, 2012, pp. 1427-36.
Zhou H, Thompson WW, Viboud CG, et al. Hospitalizations associated with influenza and respiratory syncytial virus in the United States, 1993-2008. Clin Infect Dis. 2012;54(10):1427-36.
Zhou, H., Thompson, W. W., Viboud, C. G., Ringholz, C. M., Cheng, P. Y., Steiner, C., ... Shay, D. K. (2012). Hospitalizations associated with influenza and respiratory syncytial virus in the United States, 1993-2008. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 54(10), pp. 1427-36. doi:10.1093/cid/cis211.
Zhou H, et al. Hospitalizations Associated With Influenza and Respiratory Syncytial Virus in the United States, 1993-2008. Clin Infect Dis. 2012;54(10):1427-36. PubMed PMID: 22495079.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hospitalizations associated with influenza and respiratory syncytial virus in the United States, 1993-2008. AU - Zhou,Hong, AU - Thompson,William W, AU - Viboud,Cecile G, AU - Ringholz,Corinne M, AU - Cheng,Po-Yung, AU - Steiner,Claudia, AU - Abedi,Glen R, AU - Anderson,Larry J, AU - Brammer,Lynnette, AU - Shay,David K, Y1 - 2012/04/10/ PY - 2012/4/13/entrez PY - 2012/4/13/pubmed PY - 2013/7/9/medline SP - 1427 EP - 36 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 54 IS - 10 N2 - BACKGROUND: Age-specific comparisons of influenza and respiratory syncytial virus (RSV) hospitalization rates can inform prevention efforts, including vaccine development plans. Previous US studies have not estimated jointly the burden of these viruses using similar data sources and over many seasons. METHODS: We estimated influenza and RSV hospitalizations in 5 age categories (<1, 1-4, 5-49, 50-64, and ≥65 years) with data for 13 states from 1993-1994 through 2007-2008. For each state and age group, we estimated the contribution of influenza and RSV to hospitalizations for respiratory and circulatory disease by using negative binomial regression models that incorporated weekly influenza and RSV surveillance data as covariates. RESULTS: Mean rates of influenza and RSV hospitalizations were 63.5 (95% confidence interval [CI], 37.5-237) and 55.3 (95% CI, 44.4-107) per 100000 person-years, respectively. The highest hospitalization rates for influenza were among persons aged ≥65 years (309/100000; 95% CI, 186-1100) and those aged <1 year (151/100000; 95% CI, 151-660). For RSV, children aged <1 year had the highest hospitalization rate (2350/100000; 95% CI, 2220-2520) followed by those aged 1-4 years (178/100000; 95% CI, 155-230). Age-standardized annual rates per 100000 person-years varied substantially for influenza (33-100) but less for RSV (42-77). CONCLUSIONS: Overall US hospitalization rates for influenza and RSV are similar; however, their age-specific burdens differ dramatically. Our estimates are consistent with those from previous studies focusing either on influenza or RSV. Our approach provides robust national comparisons of hospitalizations associated with these 2 viral respiratory pathogens by age group and over time. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/22495079/Hospitalizations_associated_with_influenza_and_respiratory_syncytial_virus_in_the_United_States_1993_2008_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/cis211 DB - PRIME DP - Unbound Medicine ER -