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Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis.
PLoS One 2012; 7(4):e35020Plos

Abstract

BACKGROUND

So far, many studies have investigated the distribution of CCR5 genotype between HIV-1 infected patients and uninfected people. However, no definite results have been put forward about whether heterozygosity for a 32-basepair deletion in CCR5 gene (CCR5-Δ32) can affect HIV-1 susceptibility.

METHODS

We performed a meta-analysis of 18 studies including more than 12000 subjects for whom the CCR5-Δ32 polymorphism was genotyped. Odds ratio (OR) with 95% confidence interval (CI) were employed to assess the association of CCR5-Δ32 polymorphism with HIV-1 susceptibility.

RESULTS

Compared with the wild-type CCR5 homozygotes, the pooled OR for CCR5-Δ32 heterozygotes was 1.02 (95%CI, 0.88-1.19) for healthy controls (HC) and 0.95 (95%CI, 0.71-1.26) for exposed uninfected (EU) controls. Similar results were found in stratified analysis by ethnicity, sample size and method of CCR5-Δ32 genotyping.

CONCLUSIONS

The meta-analysis indicated that HIV-1 susceptibility is not significantly affected by heterozygosity for CCR5-Δ32.

Authors+Show Affiliations

The State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22496885

Citation

Liu, Sijie, et al. "Effect of CCR5-Δ32 Heterozygosity On HIV-1 Susceptibility: a Meta-analysis." PloS One, vol. 7, no. 4, 2012, pp. e35020.
Liu S, Kong C, Wu J, et al. Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis. PLoS ONE. 2012;7(4):e35020.
Liu, S., Kong, C., Wu, J., Ying, H., & Zhu, H. (2012). Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis. PloS One, 7(4), pp. e35020. doi:10.1371/journal.pone.0035020.
Liu S, et al. Effect of CCR5-Δ32 Heterozygosity On HIV-1 Susceptibility: a Meta-analysis. PLoS ONE. 2012;7(4):e35020. PubMed PMID: 22496885.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis. AU - Liu,Sijie, AU - Kong,Chuijin, AU - Wu,Jie, AU - Ying,Hao, AU - Zhu,Huanzhang, Y1 - 2012/04/04/ PY - 2011/10/29/received PY - 2012/03/08/accepted PY - 2012/4/13/entrez PY - 2012/4/13/pubmed PY - 2012/8/24/medline SP - e35020 EP - e35020 JF - PloS one JO - PLoS ONE VL - 7 IS - 4 N2 - BACKGROUND: So far, many studies have investigated the distribution of CCR5 genotype between HIV-1 infected patients and uninfected people. However, no definite results have been put forward about whether heterozygosity for a 32-basepair deletion in CCR5 gene (CCR5-Δ32) can affect HIV-1 susceptibility. METHODS: We performed a meta-analysis of 18 studies including more than 12000 subjects for whom the CCR5-Δ32 polymorphism was genotyped. Odds ratio (OR) with 95% confidence interval (CI) were employed to assess the association of CCR5-Δ32 polymorphism with HIV-1 susceptibility. RESULTS: Compared with the wild-type CCR5 homozygotes, the pooled OR for CCR5-Δ32 heterozygotes was 1.02 (95%CI, 0.88-1.19) for healthy controls (HC) and 0.95 (95%CI, 0.71-1.26) for exposed uninfected (EU) controls. Similar results were found in stratified analysis by ethnicity, sample size and method of CCR5-Δ32 genotyping. CONCLUSIONS: The meta-analysis indicated that HIV-1 susceptibility is not significantly affected by heterozygosity for CCR5-Δ32. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/22496885/Effect_of_CCR5_Δ32_heterozygosity_on_HIV_1_susceptibility:_a_meta_analysis_ L2 - http://dx.plos.org/10.1371/journal.pone.0035020 DB - PRIME DP - Unbound Medicine ER -