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Obesity is the predominant predictor of impaired glucose tolerance and metabolic disturbance in polycystic ovary syndrome.
Acta Obstet Gynecol Scand. 2012 Oct; 91(10):1167-72.AO

Abstract

OBJECTIVE

To evaluate the contribution to glucose intolerance and metabolic syndrome of obesity combined with the diagnostic criteria of polycystic ovary syndrome (PCOS).

DESIGN

Prospective study.

SETTING

University teaching hospital from 31 August 2010 to 31 August 2011.

POPULATION

Two hundred and twenty women with PCOS and seventy normal control women.

METHODS

The clinical and biochemical characteristics of women with PCOS and control women were evaluated. Main outcome measures. The impact of obesity, hyperandrogenism, oligo-anovulation and polycystic ovary morphology on impaired glucose tolerance and metabolic disturbances.

RESULTS

Obese women with PCOS had significantly higher insulin resistance than obese normal control women. Logistic regression analysis showed that obesity was the only factor that predicted impaired glucose tolerance and metabolic syndrome. Use of the area under the receiver operating characteristic curve (AUROC) for the body mass index to predict impaired glucose tolerance and metabolic syndrome was more accurate than AUROCs for serum total testosterone level and the average menstrual interval.

CONCLUSIONS

Body weight status was the major factor determining the risk of impaired glucose tolerance and metabolic syndrome in women with PCOS. Obesity should be treated as the major factor determining long-term health consequences associated with PCOS.

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Authors+Show Affiliations

Liang SJ
Department of Obstetrics and Gynecology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Liou TH
No affiliation info available
Lin HW
No affiliation info available
Hsu CS
No affiliation info available
Tzeng CR
No affiliation info available
Hsu MI
No affiliation info available

MeSH

AdultBiomarkersBlood GlucoseBody Mass IndexCase-Control StudiesCholesterolFemaleGlucose IntoleranceGlucose Tolerance TestHumansLogistic ModelsMetabolic SyndromeObesityPolycystic Ovary SyndromeProspective StudiesROC CurveTriglycerides

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22497305

Citation

Liang, So-Jung, et al. "Obesity Is the Predominant Predictor of Impaired Glucose Tolerance and Metabolic Disturbance in Polycystic Ovary Syndrome." Acta Obstetricia Et Gynecologica Scandinavica, vol. 91, no. 10, 2012, pp. 1167-72.
Liang SJ, Liou TH, Lin HW, et al. Obesity is the predominant predictor of impaired glucose tolerance and metabolic disturbance in polycystic ovary syndrome. Acta Obstet Gynecol Scand. 2012;91(10):1167-72.
Liang, S. J., Liou, T. H., Lin, H. W., Hsu, C. S., Tzeng, C. R., & Hsu, M. I. (2012). Obesity is the predominant predictor of impaired glucose tolerance and metabolic disturbance in polycystic ovary syndrome. Acta Obstetricia Et Gynecologica Scandinavica, 91(10), 1167-72. https://doi.org/10.1111/j.1600-0412.2012.01417.x
Liang SJ, et al. Obesity Is the Predominant Predictor of Impaired Glucose Tolerance and Metabolic Disturbance in Polycystic Ovary Syndrome. Acta Obstet Gynecol Scand. 2012;91(10):1167-72. PubMed PMID: 22497305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity is the predominant predictor of impaired glucose tolerance and metabolic disturbance in polycystic ovary syndrome. AU - Liang,So-Jung, AU - Liou,Tsan-Hon, AU - Lin,Hui-Wen, AU - Hsu,Chun-Sen, AU - Tzeng,Chii-Ruey, AU - Hsu,Ming-I, Y1 - 2012/08/13/ PY - 2012/4/14/entrez PY - 2012/4/14/pubmed PY - 2012/12/10/medline SP - 1167 EP - 72 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 91 IS - 10 N2 - OBJECTIVE: To evaluate the contribution to glucose intolerance and metabolic syndrome of obesity combined with the diagnostic criteria of polycystic ovary syndrome (PCOS). DESIGN: Prospective study. SETTING: University teaching hospital from 31 August 2010 to 31 August 2011. POPULATION: Two hundred and twenty women with PCOS and seventy normal control women. METHODS: The clinical and biochemical characteristics of women with PCOS and control women were evaluated. Main outcome measures. The impact of obesity, hyperandrogenism, oligo-anovulation and polycystic ovary morphology on impaired glucose tolerance and metabolic disturbances. RESULTS: Obese women with PCOS had significantly higher insulin resistance than obese normal control women. Logistic regression analysis showed that obesity was the only factor that predicted impaired glucose tolerance and metabolic syndrome. Use of the area under the receiver operating characteristic curve (AUROC) for the body mass index to predict impaired glucose tolerance and metabolic syndrome was more accurate than AUROCs for serum total testosterone level and the average menstrual interval. CONCLUSIONS: Body weight status was the major factor determining the risk of impaired glucose tolerance and metabolic syndrome in women with PCOS. Obesity should be treated as the major factor determining long-term health consequences associated with PCOS. SN - 1600-0412 UR - https://www.unboundmedicine.com/medline/citation/22497305/Obesity_is_the_predominant_predictor_of_impaired_glucose_tolerance_and_metabolic_disturbance_in_polycystic_ovary_syndrome_ L2 - https://doi.org/10.1111/j.1600-0412.2012.01417.x DB - PRIME DP - Unbound Medicine ER -