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[Role of microglial activation induced by α-synuclein in pathogenesis of Parkinson's disease].
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2012 03; 41(2):210-4.ZD

Abstract

Parkinson's disease (PD), a progressive neurodegenerative disorder, is pathologically characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the presence of deposits of aggregated α-synuclein in intracellular inclusions known as Lewy bodies (LB). A highly localized inflammatory response mediated by reactive microglia is prominent in PD brains, but the mechanisms underlying the microglial activation are poorly understood. Recently some lines of evidences have shown that monomeric, or aggregated α-synuclein can activate microglia, the toxic factors released from activated microglia may lead to the cell death of dopaminergic neurons. This review is to summarize the recent progress on the role of α-synuclein induced microglia activation on the PD pathogenesis and progression, and to discuss the possible mechanisms involved.

Authors+Show Affiliations

Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou 310058, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

chi

PubMed ID

22499522

Citation

Qiao, Sen, et al. "[Role of Microglial Activation Induced By Α-synuclein in Pathogenesis of Parkinson's Disease]." Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences, vol. 41, no. 2, 2012, pp. 210-4.
Qiao S, Luo JH, Jin JH. [Role of microglial activation induced by α-synuclein in pathogenesis of Parkinson's disease]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2012;41(2):210-4.
Qiao, S., Luo, J. H., & Jin, J. H. (2012). [Role of microglial activation induced by α-synuclein in pathogenesis of Parkinson's disease]. Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences, 41(2), 210-4.
Qiao S, Luo JH, Jin JH. [Role of Microglial Activation Induced By Α-synuclein in Pathogenesis of Parkinson's Disease]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2012;41(2):210-4. PubMed PMID: 22499522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Role of microglial activation induced by α-synuclein in pathogenesis of Parkinson's disease]. AU - Qiao,Sen, AU - Luo,Jian-hong, AU - Jin,Jing-hua, PY - 2012/4/14/entrez PY - 2012/4/14/pubmed PY - 2012/6/22/medline SP - 210 EP - 4 JF - Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences JO - Zhejiang Da Xue Xue Bao Yi Xue Ban VL - 41 IS - 2 N2 - Parkinson's disease (PD), a progressive neurodegenerative disorder, is pathologically characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the presence of deposits of aggregated α-synuclein in intracellular inclusions known as Lewy bodies (LB). A highly localized inflammatory response mediated by reactive microglia is prominent in PD brains, but the mechanisms underlying the microglial activation are poorly understood. Recently some lines of evidences have shown that monomeric, or aggregated α-synuclein can activate microglia, the toxic factors released from activated microglia may lead to the cell death of dopaminergic neurons. This review is to summarize the recent progress on the role of α-synuclein induced microglia activation on the PD pathogenesis and progression, and to discuss the possible mechanisms involved. SN - 1008-9292 UR - https://www.unboundmedicine.com/medline/citation/22499522/[Role_of_microglial_activation_induced_by_α_synuclein_in_pathogenesis_of_Parkinson's_disease]_ L2 - https://www.diseaseinfosearch.org/result/5603 DB - PRIME DP - Unbound Medicine ER -
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