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Social deficits in male children and adolescents with sex chromosome aneuploidy: a comparison of XXY, XYY, and XXYY syndromes.
Res Dev Disabil. 2012 Jul-Aug; 33(4):1254-63.RD

Abstract

We compare social skills in three groups of males with sex chromosome aneuploidies (SCAs) using the Social Responsiveness Scale (SRS). Participants included males with XXY (N=102, M=10.08 years), XYY (N=40, M=9.93 years), and XXYY (N=32, M=11.57 years). XXY had lower (better) SRS scores compared to XYY and XXYY. Scores were not significantly different between XYY and XXYY. In all groups, there were significantly more with SRS scores in the severe range compared to the SRS normative sample. All groups scored lowest (better) on Social Motivation. Relationships between SRS scores and demographic and clinical variables were examined. Results describe the social skills in males with SCA, and suggest that an additional Y chromosome may contribute to increased risk of autistic behaviors.

Authors+Show Affiliations

University of Colorado School of Medicine -- Department of Pediatrics 13123 East 16th Ave, B140 Aurora, CO 80045, USA. Lisa.Cordeiro@childrenscolorado.orgNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22502852

Citation

Cordeiro, Lisa, et al. "Social Deficits in Male Children and Adolescents With Sex Chromosome Aneuploidy: a Comparison of XXY, XYY, and XXYY Syndromes." Research in Developmental Disabilities, vol. 33, no. 4, 2012, pp. 1254-63.
Cordeiro L, Tartaglia N, Roeltgen D, et al. Social deficits in male children and adolescents with sex chromosome aneuploidy: a comparison of XXY, XYY, and XXYY syndromes. Res Dev Disabil. 2012;33(4):1254-63.
Cordeiro, L., Tartaglia, N., Roeltgen, D., & Ross, J. (2012). Social deficits in male children and adolescents with sex chromosome aneuploidy: a comparison of XXY, XYY, and XXYY syndromes. Research in Developmental Disabilities, 33(4), 1254-63. https://doi.org/10.1016/j.ridd.2012.02.013
Cordeiro L, et al. Social Deficits in Male Children and Adolescents With Sex Chromosome Aneuploidy: a Comparison of XXY, XYY, and XXYY Syndromes. Res Dev Disabil. 2012 Jul-Aug;33(4):1254-63. PubMed PMID: 22502852.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Social deficits in male children and adolescents with sex chromosome aneuploidy: a comparison of XXY, XYY, and XXYY syndromes. AU - Cordeiro,Lisa, AU - Tartaglia,Nicole, AU - Roeltgen,David, AU - Ross,Judith, Y1 - 2012/03/23/ PY - 2012/01/19/received PY - 2012/02/08/revised PY - 2012/02/13/accepted PY - 2012/4/17/entrez PY - 2012/4/17/pubmed PY - 2012/8/15/medline SP - 1254 EP - 63 JF - Research in developmental disabilities JO - Res Dev Disabil VL - 33 IS - 4 N2 - We compare social skills in three groups of males with sex chromosome aneuploidies (SCAs) using the Social Responsiveness Scale (SRS). Participants included males with XXY (N=102, M=10.08 years), XYY (N=40, M=9.93 years), and XXYY (N=32, M=11.57 years). XXY had lower (better) SRS scores compared to XYY and XXYY. Scores were not significantly different between XYY and XXYY. In all groups, there were significantly more with SRS scores in the severe range compared to the SRS normative sample. All groups scored lowest (better) on Social Motivation. Relationships between SRS scores and demographic and clinical variables were examined. Results describe the social skills in males with SCA, and suggest that an additional Y chromosome may contribute to increased risk of autistic behaviors. SN - 1873-3379 UR - https://www.unboundmedicine.com/medline/citation/22502852/Social_deficits_in_male_children_and_adolescents_with_sex_chromosome_aneuploidy:_a_comparison_of_XXY_XYY_and_XXYY_syndromes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0891-4222(12)00041-8 DB - PRIME DP - Unbound Medicine ER -