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Vitamins E and C and medical record-confirmed age-related macular degeneration in a randomized trial of male physicians.
Ophthalmology 2012; 119(8):1642-9O

Abstract

PURPOSE

To test whether supplementation with alternate-day vitamin E or daily vitamin C affects the incidence of the diagnosis of age-related macular degeneration (AMD) in a large-scale randomized trial of male physicians.

DESIGN

Randomized, double-masked, placebo-controlled trial.

PARTICIPANTS

We included 14 236 apparently healthy United States male physicians aged ≥50 years who did not report a diagnosis of AMD at baseline.

METHODS

Participants were randomly assigned to receive 400 international units (IU) of vitamin E or placebo on alternate days, and 500 mg of vitamin C or placebo daily. Participants reported new diagnoses of AMD on annual questionnaires and medical record data were collected to confirm the reports.

MAIN OUTCOME MEASURES

Incident diagnosis of AMD responsible for a reduction in best-corrected visual acuity to ≤20/30.

RESULTS

After 8 years of treatment and follow-up, a total of 193 incident cases of visually significant AMD were documented. There were 96 cases in the vitamin E group and 97 in the placebo group (hazard ratio [HR], 1.03; 95% confidence interval [CI], 0.78-1.37). For vitamin C, there were 97 cases in the active group and 96 in the placebo group (HR, 0.99; 95% CI, 0.75-1.31).

CONCLUSIONS

In a large-scale, randomized trial of United States male physicians, alternate-day use of 400 IU of vitamin E and/or daily use of 500 mg of vitamin C for 8 years had no appreciable beneficial or harmful effect on risk of incident diagnosis of AMD.

Authors+Show Affiliations

Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. wchristen@rics.bwh.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22503302

Citation

Christen, William G., et al. "Vitamins E and C and Medical Record-confirmed Age-related Macular Degeneration in a Randomized Trial of Male Physicians." Ophthalmology, vol. 119, no. 8, 2012, pp. 1642-9.
Christen WG, Glynn RJ, Sesso HD, et al. Vitamins E and C and medical record-confirmed age-related macular degeneration in a randomized trial of male physicians. Ophthalmology. 2012;119(8):1642-9.
Christen, W. G., Glynn, R. J., Sesso, H. D., Kurth, T., Macfadyen, J., Bubes, V., ... Gaziano, J. M. (2012). Vitamins E and C and medical record-confirmed age-related macular degeneration in a randomized trial of male physicians. Ophthalmology, 119(8), pp. 1642-9. doi:10.1016/j.ophtha.2012.01.053.
Christen WG, et al. Vitamins E and C and Medical Record-confirmed Age-related Macular Degeneration in a Randomized Trial of Male Physicians. Ophthalmology. 2012;119(8):1642-9. PubMed PMID: 22503302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamins E and C and medical record-confirmed age-related macular degeneration in a randomized trial of male physicians. AU - Christen,William G, AU - Glynn,Robert J, AU - Sesso,Howard D, AU - Kurth,Tobias, AU - Macfadyen,Jean, AU - Bubes,Vadim, AU - Buring,Julie E, AU - Manson,Joann E, AU - Gaziano,J Michael, Y1 - 2012/04/13/ PY - 2011/08/04/received PY - 2012/01/27/revised PY - 2012/01/30/accepted PY - 2012/4/17/entrez PY - 2012/4/17/pubmed PY - 2012/10/26/medline SP - 1642 EP - 9 JF - Ophthalmology JO - Ophthalmology VL - 119 IS - 8 N2 - PURPOSE: To test whether supplementation with alternate-day vitamin E or daily vitamin C affects the incidence of the diagnosis of age-related macular degeneration (AMD) in a large-scale randomized trial of male physicians. DESIGN: Randomized, double-masked, placebo-controlled trial. PARTICIPANTS: We included 14 236 apparently healthy United States male physicians aged ≥50 years who did not report a diagnosis of AMD at baseline. METHODS: Participants were randomly assigned to receive 400 international units (IU) of vitamin E or placebo on alternate days, and 500 mg of vitamin C or placebo daily. Participants reported new diagnoses of AMD on annual questionnaires and medical record data were collected to confirm the reports. MAIN OUTCOME MEASURES: Incident diagnosis of AMD responsible for a reduction in best-corrected visual acuity to ≤20/30. RESULTS: After 8 years of treatment and follow-up, a total of 193 incident cases of visually significant AMD were documented. There were 96 cases in the vitamin E group and 97 in the placebo group (hazard ratio [HR], 1.03; 95% confidence interval [CI], 0.78-1.37). For vitamin C, there were 97 cases in the active group and 96 in the placebo group (HR, 0.99; 95% CI, 0.75-1.31). CONCLUSIONS: In a large-scale, randomized trial of United States male physicians, alternate-day use of 400 IU of vitamin E and/or daily use of 500 mg of vitamin C for 8 years had no appreciable beneficial or harmful effect on risk of incident diagnosis of AMD. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/22503302/Vitamins_E_and_C_and_medical_record_confirmed_age_related_macular_degeneration_in_a_randomized_trial_of_male_physicians_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(12)00114-5 DB - PRIME DP - Unbound Medicine ER -