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Stability considerations of aspartame in the direct analysis of artificial sweeteners in water samples using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).
Chemosphere. 2012 Jul; 88(5):563-9.C

Abstract

A HPLC-MS/MS method is presented for the simultaneous determination of frequently used artificial sweeteners (ASs) and the main metabolite of aspartame (ASP), diketopiperazine (DKP), in environmental water samples using the direct-injection (DI) technique, thereby achieving limits of quantification (LOQ) of 10 ng L(-1). For a reliable quantification of ASP pH should be adjusted to 4.3 to prevent formation of the metabolite. Acesulfame (ACE), saccharin (SAC), cyclamate (CYC) and sucralose (SUC) were ubiquitously found in water samples. Highest concentrations up to 61 μg L(-1) of ACE were found in wastewater effluents, followed by surface water with concentrations up to 7 μg L(-1), lakes up to 600 ng L(-1) and groundwater and tap water up to 70 ng L(-1). The metabolite DKP was only detected in wastewater up to 200 ng L(-1) and at low detection frequencies.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Berset JD
Water and Soil Protection Laboratory, Environmental Organic Chemistry Group, Office of Water and Waste, Schermenweg 11, Bern, Switzerland. jean-daniel.berset@bve.be.ch
Ochsenbein N
No affiliation info available

MeSH

AspartameChromatography, High Pressure LiquidDrug StabilityGroundwaterKineticsReproducibility of ResultsSweetening AgentsTandem Mass SpectrometryWaste Disposal, FluidWaterWater Pollutants, Chemical

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22503463

Citation

Berset, Jean-Daniel, and Nicole Ochsenbein. "Stability Considerations of Aspartame in the Direct Analysis of Artificial Sweeteners in Water Samples Using High-performance Liquid Chromatography-tandem Mass Spectrometry (HPLC-MS/MS)." Chemosphere, vol. 88, no. 5, 2012, pp. 563-9.
Berset JD, Ochsenbein N. Stability considerations of aspartame in the direct analysis of artificial sweeteners in water samples using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Chemosphere. 2012;88(5):563-9.
Berset, J. D., & Ochsenbein, N. (2012). Stability considerations of aspartame in the direct analysis of artificial sweeteners in water samples using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Chemosphere, 88(5), 563-9. https://doi.org/10.1016/j.chemosphere.2012.03.030
Berset JD, Ochsenbein N. Stability Considerations of Aspartame in the Direct Analysis of Artificial Sweeteners in Water Samples Using High-performance Liquid Chromatography-tandem Mass Spectrometry (HPLC-MS/MS). Chemosphere. 2012;88(5):563-9. PubMed PMID: 22503463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stability considerations of aspartame in the direct analysis of artificial sweeteners in water samples using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). AU - Berset,Jean-Daniel, AU - Ochsenbein,Nicole, Y1 - 2012/04/12/ PY - 2011/08/23/received PY - 2012/03/04/revised PY - 2012/03/06/accepted PY - 2012/4/17/entrez PY - 2012/4/17/pubmed PY - 2012/9/25/medline SP - 563 EP - 9 JF - Chemosphere JO - Chemosphere VL - 88 IS - 5 N2 - A HPLC-MS/MS method is presented for the simultaneous determination of frequently used artificial sweeteners (ASs) and the main metabolite of aspartame (ASP), diketopiperazine (DKP), in environmental water samples using the direct-injection (DI) technique, thereby achieving limits of quantification (LOQ) of 10 ng L(-1). For a reliable quantification of ASP pH should be adjusted to 4.3 to prevent formation of the metabolite. Acesulfame (ACE), saccharin (SAC), cyclamate (CYC) and sucralose (SUC) were ubiquitously found in water samples. Highest concentrations up to 61 μg L(-1) of ACE were found in wastewater effluents, followed by surface water with concentrations up to 7 μg L(-1), lakes up to 600 ng L(-1) and groundwater and tap water up to 70 ng L(-1). The metabolite DKP was only detected in wastewater up to 200 ng L(-1) and at low detection frequencies. SN - 1879-1298 UR - https://www.unboundmedicine.com/medline/citation/22503463/Stability_considerations_of_aspartame_in_the_direct_analysis_of_artificial_sweeteners_in_water_samples_using_high_performance_liquid_chromatography_tandem_mass_spectrometry__HPLC_MS/MS__ DB - PRIME DP - Unbound Medicine ER -