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At the heart of the matter: the endocannabinoid system in cardiovascular function and dysfunction.
Trends Pharmacol Sci. 2012 Jun; 33(6):331-40.TP

Abstract

Starting from the well-documented effects of marijuana smoking on heart rate and blood pressure, the cardiovascular effects of Δ⁹-tetrahydrocannabinol (THC, the main psychotropic ingredient of Cannabis) and endocannabinoids [THC endogenous counterparts that activate cannabinoid receptor type 1 (CB₁) and 2 (CB₂)] have been thoroughly investigated. These studies were mostly aimed at establishing the molecular bases of the hypotensive actions of THC, endocannabinoids and related molecules, but also evaluated their therapeutic potential in cardiac injury protection, metabolic cardiovascular risk factors and atherosclerotic plaque vulnerability. The results of these investigations, reviewed here, also served to highlight some of the most peculiar aspects of endocannabinoid signaling, such as redundancy in endocannabinoid targets and the often dualistic role of CB₁ and CB₂ receptors during pathological conditions.

Authors+Show Affiliations

Division of Cardiology, Faculty of Medicine, Foundation for Medical Researches, Geneva University Hospitals, Avenue de la Roseraie 64, 1211 Geneva 4, Switzerland.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22503477

Citation

Montecucco, Fabrizio, and Vincenzo Di Marzo. "At the Heart of the Matter: the Endocannabinoid System in Cardiovascular Function and Dysfunction." Trends in Pharmacological Sciences, vol. 33, no. 6, 2012, pp. 331-40.
Montecucco F, Di Marzo V. At the heart of the matter: the endocannabinoid system in cardiovascular function and dysfunction. Trends Pharmacol Sci. 2012;33(6):331-40.
Montecucco, F., & Di Marzo, V. (2012). At the heart of the matter: the endocannabinoid system in cardiovascular function and dysfunction. Trends in Pharmacological Sciences, 33(6), 331-40. https://doi.org/10.1016/j.tips.2012.03.002
Montecucco F, Di Marzo V. At the Heart of the Matter: the Endocannabinoid System in Cardiovascular Function and Dysfunction. Trends Pharmacol Sci. 2012;33(6):331-40. PubMed PMID: 22503477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - At the heart of the matter: the endocannabinoid system in cardiovascular function and dysfunction. AU - Montecucco,Fabrizio, AU - Di Marzo,Vincenzo, Y1 - 2012/04/13/ PY - 2012/01/09/received PY - 2012/02/22/revised PY - 2012/03/05/accepted PY - 2012/4/17/entrez PY - 2012/4/17/pubmed PY - 2012/10/16/medline SP - 331 EP - 40 JF - Trends in pharmacological sciences JO - Trends Pharmacol Sci VL - 33 IS - 6 N2 - Starting from the well-documented effects of marijuana smoking on heart rate and blood pressure, the cardiovascular effects of Δ⁹-tetrahydrocannabinol (THC, the main psychotropic ingredient of Cannabis) and endocannabinoids [THC endogenous counterparts that activate cannabinoid receptor type 1 (CB₁) and 2 (CB₂)] have been thoroughly investigated. These studies were mostly aimed at establishing the molecular bases of the hypotensive actions of THC, endocannabinoids and related molecules, but also evaluated their therapeutic potential in cardiac injury protection, metabolic cardiovascular risk factors and atherosclerotic plaque vulnerability. The results of these investigations, reviewed here, also served to highlight some of the most peculiar aspects of endocannabinoid signaling, such as redundancy in endocannabinoid targets and the often dualistic role of CB₁ and CB₂ receptors during pathological conditions. SN - 1873-3735 UR - https://www.unboundmedicine.com/medline/citation/22503477/At_the_heart_of_the_matter:_the_endocannabinoid_system_in_cardiovascular_function_and_dysfunction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-6147(12)00034-X DB - PRIME DP - Unbound Medicine ER -