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Physiopathology and diagnosis of nephrogenic diabetes insipidus.
Ann Endocrinol (Paris). 2012 Apr; 73(2):128-9.AE

Abstract

Nephrogenic diabetes insipidus (NDI) is caused by an improper response of the kidney to the antidiuretic hormone arginine vasopressin (AVP), leading to a decreased ability to concentrate urine which results in polyuria and polydipsia. The clinical diagnosis of NDI relies on demonstration of subnormal ability to concentrate urine despite the presence of AVP. NDI is most commonly acquired, secondary to kidney disorders, electrolyte imbalance and various drugs. Congenital forms of NDI are rare, and most commonly inherited in a X-linked manner with mutations of the AVP receptor type 2 (AVPR2). Mutations of the water channel aquaporin-2 (AQP2) can be detected in autosomal recessive or dominant forms of NDI. Management of NDI should focus on free access to drinking water and reduction of polyuria.

Authors+Show Affiliations

Institute of Physiology, Zurich Center for Integrative Human Physiology, Switzerland. olivier.devuyst@uzh.ch

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22503803

Citation

Devuyst, Olivier. "Physiopathology and Diagnosis of Nephrogenic Diabetes Insipidus." Annales D'endocrinologie, vol. 73, no. 2, 2012, pp. 128-9.
Devuyst O. Physiopathology and diagnosis of nephrogenic diabetes insipidus. Ann Endocrinol (Paris). 2012;73(2):128-9.
Devuyst, O. (2012). Physiopathology and diagnosis of nephrogenic diabetes insipidus. Annales D'endocrinologie, 73(2), 128-9. https://doi.org/10.1016/j.ando.2012.03.032
Devuyst O. Physiopathology and Diagnosis of Nephrogenic Diabetes Insipidus. Ann Endocrinol (Paris). 2012;73(2):128-9. PubMed PMID: 22503803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physiopathology and diagnosis of nephrogenic diabetes insipidus. A1 - Devuyst,Olivier, Y1 - 2012/04/13/ PY - 2012/4/17/entrez PY - 2012/4/17/pubmed PY - 2012/9/15/medline SP - 128 EP - 9 JF - Annales d'endocrinologie JO - Ann. Endocrinol. (Paris) VL - 73 IS - 2 N2 - Nephrogenic diabetes insipidus (NDI) is caused by an improper response of the kidney to the antidiuretic hormone arginine vasopressin (AVP), leading to a decreased ability to concentrate urine which results in polyuria and polydipsia. The clinical diagnosis of NDI relies on demonstration of subnormal ability to concentrate urine despite the presence of AVP. NDI is most commonly acquired, secondary to kidney disorders, electrolyte imbalance and various drugs. Congenital forms of NDI are rare, and most commonly inherited in a X-linked manner with mutations of the AVP receptor type 2 (AVPR2). Mutations of the water channel aquaporin-2 (AQP2) can be detected in autosomal recessive or dominant forms of NDI. Management of NDI should focus on free access to drinking water and reduction of polyuria. SN - 2213-3941 UR - https://www.unboundmedicine.com/medline/citation/22503803/Physiopathology_and_diagnosis_of_nephrogenic_diabetes_insipidus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-4266(12)00056-X DB - PRIME DP - Unbound Medicine ER -