Tags

Type your tag names separated by a space and hit enter

Non-apnea sleep disorders will increase subsequent liver cancer risk--a nationwide population-based cohort study.
Sleep Med. 2012 Aug; 13(7):869-74.SM

Abstract

INTRODUCTION

It is well known that patients with sleep disorders (SD) have an increased risk of cardiovascular disease, diabetes mellitus, obesity, and total mortality. However, little information exists regarding the relationship between non-apnea SD and the risk of cancer. The goal of this study was to determine if any association between SD and malignancy exists in Taiwan.

METHODS

We used data from the National Health Insurance system of Taiwan to assess this issue. The SD cohort contained 42,351 patients, and each patient was randomly frequency-matched by age and sex with two people from the general population without SD. The Cox's proportional hazard regression analysis was conducted to estimate the effects of SD on cancer risk.

RESULTS

In patients with SD, the overall risk of developing cancer was significantly higher than in normal healthy subjects (adjusted Hazard ratio [HR]=1.12, 95% confidence interval=1.06-1.18). This held true even when we analyzed males and females separately. In regards to individual types of cancer, the risk for developing liver cancer among patients with SD was significantly higher than in subjects without SD. For breast cancer the risk showed a marginally significant increase.

CONCLUSION

The nationwide population-based cohort study found Taiwanese patients with SD have a higher risk of developing cancer, particularly liver cancer and, possibly, breast cancer.

Authors+Show Affiliations

Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22503943

Citation

Liang, Ji-An, et al. "Non-apnea Sleep Disorders Will Increase Subsequent Liver Cancer Risk--a Nationwide Population-based Cohort Study." Sleep Medicine, vol. 13, no. 7, 2012, pp. 869-74.
Liang JA, Sun LM, Muo CH, et al. Non-apnea sleep disorders will increase subsequent liver cancer risk--a nationwide population-based cohort study. Sleep Med. 2012;13(7):869-74.
Liang, J. A., Sun, L. M., Muo, C. H., Sung, F. C., Chang, S. N., & Kao, C. H. (2012). Non-apnea sleep disorders will increase subsequent liver cancer risk--a nationwide population-based cohort study. Sleep Medicine, 13(7), 869-74. https://doi.org/10.1016/j.sleep.2012.02.005
Liang JA, et al. Non-apnea Sleep Disorders Will Increase Subsequent Liver Cancer Risk--a Nationwide Population-based Cohort Study. Sleep Med. 2012;13(7):869-74. PubMed PMID: 22503943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-apnea sleep disorders will increase subsequent liver cancer risk--a nationwide population-based cohort study. AU - Liang,Ji-An, AU - Sun,Li-Min, AU - Muo,Chih-Hsin, AU - Sung,Fung-Chang, AU - Chang,Shih-Ni, AU - Kao,Chia-Hung, Y1 - 2012/04/13/ PY - 2011/11/02/received PY - 2012/02/13/revised PY - 2012/02/14/accepted PY - 2012/4/17/entrez PY - 2012/4/17/pubmed PY - 2012/12/10/medline SP - 869 EP - 74 JF - Sleep medicine JO - Sleep Med. VL - 13 IS - 7 N2 - INTRODUCTION: It is well known that patients with sleep disorders (SD) have an increased risk of cardiovascular disease, diabetes mellitus, obesity, and total mortality. However, little information exists regarding the relationship between non-apnea SD and the risk of cancer. The goal of this study was to determine if any association between SD and malignancy exists in Taiwan. METHODS: We used data from the National Health Insurance system of Taiwan to assess this issue. The SD cohort contained 42,351 patients, and each patient was randomly frequency-matched by age and sex with two people from the general population without SD. The Cox's proportional hazard regression analysis was conducted to estimate the effects of SD on cancer risk. RESULTS: In patients with SD, the overall risk of developing cancer was significantly higher than in normal healthy subjects (adjusted Hazard ratio [HR]=1.12, 95% confidence interval=1.06-1.18). This held true even when we analyzed males and females separately. In regards to individual types of cancer, the risk for developing liver cancer among patients with SD was significantly higher than in subjects without SD. For breast cancer the risk showed a marginally significant increase. CONCLUSION: The nationwide population-based cohort study found Taiwanese patients with SD have a higher risk of developing cancer, particularly liver cancer and, possibly, breast cancer. SN - 1878-5506 UR - https://www.unboundmedicine.com/medline/citation/22503943/Non_apnea_sleep_disorders_will_increase_subsequent_liver_cancer_risk__a_nationwide_population_based_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1389-9457(12)00104-9 DB - PRIME DP - Unbound Medicine ER -