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Higher vitamin D dietary intake is associated with lower risk of alzheimer's disease: a 7-year follow-up.
J Gerontol A Biol Sci Med Sci. 2012 Nov; 67(11):1205-11.JG

Abstract

BACKGROUND

Hypovitaminosis D is associated with cognitive decline among older adults. The relationship between vitamin D intakes and cognitive decline is not well understood. Our objective was to determine whether the dietary intake of vitamin D was an independent predictor of the onset of dementia within 7 years among women aged 75 years and older.

METHODS

Four hundred and ninety-eight community-dwelling women (mean, 79.8 ± 3.8 years) free of vitamin D supplements from the EPIDemiology of OSteoporosis Toulouse cohort study were divided into three groups according to the onset of dementia within 7 years (ie, no dementia, Alzheimer's disease [AD], or other dementias). Baseline vitamin D dietary intakes were estimated from self-administered food frequency questionnaire. Age, body mass index, initial cognitive performance, education level, physical activity, sun exposure, disability, number of chronic diseases, hypertension, depression, use of psychoactive drugs, and baseline season were considered as potential confounders.

RESULTS

Women who developed AD (n = 70) had lower baseline vitamin D intakes (mean, 50.3 ± 19.3 μg/wk) than nondemented (n = 361; mean intake = 59.0 ± 29.9 μg/wk, p = .027) or those who developed other dementias (n = 67; mean intake = 63.6 ± 38.1 μg/wk, p = .010). There was no difference between other dementias and no dementia (p = .247). Baseline vitamin D dietary intakes were associated with the onset of AD (adjusted odds ratio = 0.99 [95% confidence interval = 0.98-0.99], p = .041) but not with other dementias (p = .071). Being in the highest quintile of vitamin D dietary intakes was associated with a lower risk of AD compared with the lower 4 quintiles combined (adjusted odds ratio = 0.23 [95% confidence interval = 0.08-0.67], p = .007).

CONCLUSIONS

Higher vitamin D dietary intake was associated with a lower risk of developing AD among older women.

Authors+Show Affiliations

Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, 49933 Angers, France. ceannweiler@chu-angers.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22503994

Citation

Annweiler, Cédric, et al. "Higher Vitamin D Dietary Intake Is Associated With Lower Risk of Alzheimer's Disease: a 7-year Follow-up." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 67, no. 11, 2012, pp. 1205-11.
Annweiler C, Rolland Y, Schott AM, et al. Higher vitamin D dietary intake is associated with lower risk of alzheimer's disease: a 7-year follow-up. J Gerontol A Biol Sci Med Sci. 2012;67(11):1205-11.
Annweiler, C., Rolland, Y., Schott, A. M., Blain, H., Vellas, B., Herrmann, F. R., & Beauchet, O. (2012). Higher vitamin D dietary intake is associated with lower risk of alzheimer's disease: a 7-year follow-up. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 67(11), 1205-11. https://doi.org/10.1093/gerona/gls107
Annweiler C, et al. Higher Vitamin D Dietary Intake Is Associated With Lower Risk of Alzheimer's Disease: a 7-year Follow-up. J Gerontol A Biol Sci Med Sci. 2012;67(11):1205-11. PubMed PMID: 22503994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher vitamin D dietary intake is associated with lower risk of alzheimer's disease: a 7-year follow-up. AU - Annweiler,Cédric, AU - Rolland,Yves, AU - Schott,Anne M, AU - Blain,Hubert, AU - Vellas,Bruno, AU - Herrmann,François R, AU - Beauchet,Olivier, Y1 - 2012/04/13/ PY - 2012/4/17/entrez PY - 2012/4/17/pubmed PY - 2013/1/11/medline SP - 1205 EP - 11 JF - The journals of gerontology. Series A, Biological sciences and medical sciences JO - J. Gerontol. A Biol. Sci. Med. Sci. VL - 67 IS - 11 N2 - BACKGROUND: Hypovitaminosis D is associated with cognitive decline among older adults. The relationship between vitamin D intakes and cognitive decline is not well understood. Our objective was to determine whether the dietary intake of vitamin D was an independent predictor of the onset of dementia within 7 years among women aged 75 years and older. METHODS: Four hundred and ninety-eight community-dwelling women (mean, 79.8 ± 3.8 years) free of vitamin D supplements from the EPIDemiology of OSteoporosis Toulouse cohort study were divided into three groups according to the onset of dementia within 7 years (ie, no dementia, Alzheimer's disease [AD], or other dementias). Baseline vitamin D dietary intakes were estimated from self-administered food frequency questionnaire. Age, body mass index, initial cognitive performance, education level, physical activity, sun exposure, disability, number of chronic diseases, hypertension, depression, use of psychoactive drugs, and baseline season were considered as potential confounders. RESULTS: Women who developed AD (n = 70) had lower baseline vitamin D intakes (mean, 50.3 ± 19.3 μg/wk) than nondemented (n = 361; mean intake = 59.0 ± 29.9 μg/wk, p = .027) or those who developed other dementias (n = 67; mean intake = 63.6 ± 38.1 μg/wk, p = .010). There was no difference between other dementias and no dementia (p = .247). Baseline vitamin D dietary intakes were associated with the onset of AD (adjusted odds ratio = 0.99 [95% confidence interval = 0.98-0.99], p = .041) but not with other dementias (p = .071). Being in the highest quintile of vitamin D dietary intakes was associated with a lower risk of AD compared with the lower 4 quintiles combined (adjusted odds ratio = 0.23 [95% confidence interval = 0.08-0.67], p = .007). CONCLUSIONS: Higher vitamin D dietary intake was associated with a lower risk of developing AD among older women. SN - 1758-535X UR - https://www.unboundmedicine.com/medline/citation/22503994/Higher_vitamin_D_dietary_intake_is_associated_with_lower_risk_of_alzheimer's_disease:_a_7_year_follow_up_ L2 - https://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/gls107 DB - PRIME DP - Unbound Medicine ER -