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Effects of annual influenza vaccination on mortality and hospitalization in elderly patients with ischemic heart disease: a nationwide population-based study.

Abstract

OBJECTIVE

The effects of influenza vaccination on ischemic heart disease (IHD) patients remain controversial. The purpose of this study was to evaluate the effects of influenza vaccination on all-cause mortality and hospitalization for cardiovascular disease in elderly IHD patients.

METHODS

Elderly patients (>65 years old) with IHD, including ischemic heart failure and coronary artery disease between January 1997 and September 2002 were identified by using the Taiwan National Health Insurance Research Database. The association between influenza vaccination and all-cause mortality and hospitalization due to cardiovascular disease was analyzed.

RESULTS

We included 5048 patients. During the influenza season, influenza vaccination was associated with a reduced risk of all-cause mortality [hazard ratio (HR), 0.42; 95% confidence interval (CI) 0.35-0.49] and hospitalization for cardiovascular disease (HR, 0.84; 95% CI, 0.76-0.93). During the non-influenza season, vaccination was associated with a reduced risk of mortality (HR, 0.78; 95% CI, 0.68-0.90) in elderly IHD patients.

CONCLUSION

Influenza vaccination was associated with a reduced risk of all-cause mortality in elderly IHD patients throughout the whole year, as well as a reduced risk of hospitalization during the influenza season.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Medicine, Taipei Veterans General Hospital, Taoyuan Branch, Taoyuan, Taiwan.

    , , , , , ,

    Source

    Preventive medicine 54:6 2012 Jun pg 431-3

    MeSH

    Aged
    Aged, 80 and over
    Cohort Studies
    Female
    Hospitalization
    Humans
    Influenza Vaccines
    Influenza, Human
    Male
    Mortality
    Myocardial Ischemia
    Outcome Assessment (Health Care)
    Population Surveillance
    Seasons
    Taiwan
    Vaccination

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22504030

    Citation

    Liu, I-Fan, et al. "Effects of Annual Influenza Vaccination On Mortality and Hospitalization in Elderly Patients With Ischemic Heart Disease: a Nationwide Population-based Study." Preventive Medicine, vol. 54, no. 6, 2012, pp. 431-3.
    Liu IF, Huang CC, Chan WL, et al. Effects of annual influenza vaccination on mortality and hospitalization in elderly patients with ischemic heart disease: a nationwide population-based study. Prev Med. 2012;54(6):431-3.
    Liu, I. F., Huang, C. C., Chan, W. L., Huang, P. H., Chung, C. M., Lin, S. J., ... Leu, H. B. (2012). Effects of annual influenza vaccination on mortality and hospitalization in elderly patients with ischemic heart disease: a nationwide population-based study. Preventive Medicine, 54(6), pp. 431-3. doi:10.1016/j.ypmed.2012.03.020.
    Liu IF, et al. Effects of Annual Influenza Vaccination On Mortality and Hospitalization in Elderly Patients With Ischemic Heart Disease: a Nationwide Population-based Study. Prev Med. 2012;54(6):431-3. PubMed PMID: 22504030.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of annual influenza vaccination on mortality and hospitalization in elderly patients with ischemic heart disease: a nationwide population-based study. AU - Liu,I-Fan, AU - Huang,Chin-Chou, AU - Chan,Wan-Leong, AU - Huang,Po-Hsun, AU - Chung,Chia-Min, AU - Lin,Shing-Jong, AU - Chen,Jaw-Wen, AU - Leu,Hsin-Bang, Y1 - 2012/04/04/ PY - 2011/09/28/received PY - 2012/02/06/revised PY - 2012/03/28/accepted PY - 2012/4/17/entrez PY - 2012/4/17/pubmed PY - 2012/9/15/medline SP - 431 EP - 3 JF - Preventive medicine JO - Prev Med VL - 54 IS - 6 N2 - OBJECTIVE: The effects of influenza vaccination on ischemic heart disease (IHD) patients remain controversial. The purpose of this study was to evaluate the effects of influenza vaccination on all-cause mortality and hospitalization for cardiovascular disease in elderly IHD patients. METHODS: Elderly patients (>65 years old) with IHD, including ischemic heart failure and coronary artery disease between January 1997 and September 2002 were identified by using the Taiwan National Health Insurance Research Database. The association between influenza vaccination and all-cause mortality and hospitalization due to cardiovascular disease was analyzed. RESULTS: We included 5048 patients. During the influenza season, influenza vaccination was associated with a reduced risk of all-cause mortality [hazard ratio (HR), 0.42; 95% confidence interval (CI) 0.35-0.49] and hospitalization for cardiovascular disease (HR, 0.84; 95% CI, 0.76-0.93). During the non-influenza season, vaccination was associated with a reduced risk of mortality (HR, 0.78; 95% CI, 0.68-0.90) in elderly IHD patients. CONCLUSION: Influenza vaccination was associated with a reduced risk of all-cause mortality in elderly IHD patients throughout the whole year, as well as a reduced risk of hospitalization during the influenza season. SN - 1096-0260 UR - https://www.unboundmedicine.com/medline/citation/22504030/Effects_of_annual_influenza_vaccination_on_mortality_and_hospitalization_in_elderly_patients_with_ischemic_heart_disease:_a_nationwide_population_based_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-7435(12)00106-5 DB - PRIME DP - Unbound Medicine ER -