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Rheum australe D. Don: a review of its botany, ethnobotany, phytochemistry and pharmacology.
J Ethnopharmacol. 2012 Jun 14; 141(3):761-74.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Rheum australe D. Don (Polygonaceae) has been commonly used in traditional medicine for a wide range of ailments related to the circulatory, digestive, endocrine, respiratory and skeletal systems as well as to infectious diseases.

AIM OF THE REVIEW

To provide the up-to-date information that is available on the botany, traditional uses, phytochemistry, pharmacology and toxicology of Rheum australe. Additionally, to highlight the possible uses of this species to treat different diseases and to provide a basis for future research.

MATERIALS AND METHODS

The present review covers the literature available from 1980 to 2011. The information was collected from scientific journals, books, theses and reports via a library and electronic search (Google Scholar, Web of Science and ScienceDirect).

RESULTS

Ethnomedical uses of Rheum australe have been recorded from China, India, Nepal and Pakistan for 57 different types of ailments. The phytochemical studies have shown the presence of many secondary metabolites belonging to anthraquinones, stilbenes, anthrones, oxantrone ethers and esters, chromones, flavonoids, carbohydrate, lignans, phenols and sterols. Crude extracts and isolated compounds from Rheum australe show a wide spectrum of pharmacological activities, such as antidiabetic, anti-inflammatory, antifungal, antimicrobial, antioxidant, anticancer, hepatoprotective and immune-enhancing activities, as well as a usefulness for improving renal function.

CONCLUSION

Rheum australe has been widely used source of medicine for years without any adverse effects. Many studies have provided evidence for various traditional uses. However, there is a need for additional studies of the isolated compounds to validate the traditional uses in human models. The present review on the botany, traditional uses, phytochemistry and toxicity has provided preliminary information for further studies and commercial exploitations of the plant.

Authors+Show Affiliations

Institute of Botany, Academy of Sciences of the Czech Republic, Zamek 1, CZ-252 43 Průhonice, Czech Republic. rokayamaan@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22504148

Citation

Rokaya, Maan Bahadur, et al. "Rheum Australe D. Don: a Review of Its Botany, Ethnobotany, Phytochemistry and Pharmacology." Journal of Ethnopharmacology, vol. 141, no. 3, 2012, pp. 761-74.
Rokaya MB, Münzbergová Z, Timsina B, et al. Rheum australe D. Don: a review of its botany, ethnobotany, phytochemistry and pharmacology. J Ethnopharmacol. 2012;141(3):761-74.
Rokaya, M. B., Münzbergová, Z., Timsina, B., & Bhattarai, K. R. (2012). Rheum australe D. Don: a review of its botany, ethnobotany, phytochemistry and pharmacology. Journal of Ethnopharmacology, 141(3), 761-74. https://doi.org/10.1016/j.jep.2012.03.048
Rokaya MB, et al. Rheum Australe D. Don: a Review of Its Botany, Ethnobotany, Phytochemistry and Pharmacology. J Ethnopharmacol. 2012 Jun 14;141(3):761-74. PubMed PMID: 22504148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rheum australe D. Don: a review of its botany, ethnobotany, phytochemistry and pharmacology. AU - Rokaya,Maan Bahadur, AU - Münzbergová,Zuzana, AU - Timsina,Binu, AU - Bhattarai,Krishna Ram, Y1 - 2012/04/05/ PY - 2011/11/28/received PY - 2012/03/26/revised PY - 2012/03/27/accepted PY - 2012/4/17/entrez PY - 2012/4/17/pubmed PY - 2012/9/29/medline SP - 761 EP - 74 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 141 IS - 3 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Rheum australe D. Don (Polygonaceae) has been commonly used in traditional medicine for a wide range of ailments related to the circulatory, digestive, endocrine, respiratory and skeletal systems as well as to infectious diseases. AIM OF THE REVIEW: To provide the up-to-date information that is available on the botany, traditional uses, phytochemistry, pharmacology and toxicology of Rheum australe. Additionally, to highlight the possible uses of this species to treat different diseases and to provide a basis for future research. MATERIALS AND METHODS: The present review covers the literature available from 1980 to 2011. The information was collected from scientific journals, books, theses and reports via a library and electronic search (Google Scholar, Web of Science and ScienceDirect). RESULTS: Ethnomedical uses of Rheum australe have been recorded from China, India, Nepal and Pakistan for 57 different types of ailments. The phytochemical studies have shown the presence of many secondary metabolites belonging to anthraquinones, stilbenes, anthrones, oxantrone ethers and esters, chromones, flavonoids, carbohydrate, lignans, phenols and sterols. Crude extracts and isolated compounds from Rheum australe show a wide spectrum of pharmacological activities, such as antidiabetic, anti-inflammatory, antifungal, antimicrobial, antioxidant, anticancer, hepatoprotective and immune-enhancing activities, as well as a usefulness for improving renal function. CONCLUSION: Rheum australe has been widely used source of medicine for years without any adverse effects. Many studies have provided evidence for various traditional uses. However, there is a need for additional studies of the isolated compounds to validate the traditional uses in human models. The present review on the botany, traditional uses, phytochemistry and toxicity has provided preliminary information for further studies and commercial exploitations of the plant. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/22504148/Rheum_australe_D__Don:_a_review_of_its_botany_ethnobotany_phytochemistry_and_pharmacology_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(12)00210-3 DB - PRIME DP - Unbound Medicine ER -