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Effect of moisturizers on epidermal barrier function.
Clin Dermatol. 2012 May-Jun; 30(3):286-96.CD

Abstract

A daily moisturizing routine is a vital part of the management of patients with atopic dermatitis and other dry skin conditions. The composition of the moisturizer determines whether the treatment strengthens or deteriorates the skin barrier function, which may have consequences for the outcome of the dermatitis. One might expect that a patient's impaired skin barrier function should improve in association with a reduction in the clinical signs of dryness. Despite visible relief of the dryness symptoms, however, the abnormal transepidermal water loss has been reported to remain high, or even to increase under certain regimens, whereas other moisturizers improve skin barrier function. Differing outcomes have also been reported in healthy skin: some moisturizers produce deterioration in skin barrier function and others improve the skin. Possible targets for barrier-influencing moisturizing creams include the intercellular lipid bilayers, where the fraction of lipids forming a fluid phase might be changed due to compositional or organizational changes. Other targets are the projected size of the corneocytes or the thickness of the stratum corneum. Moisturizers with barrier-improving properties may delay relapse of dermatitis in patients with atopic dermatitis. In a worst-case scenario, treatment with moisturizing creams could increase the risks of dermatitis and asthma.

Authors+Show Affiliations

Eviderm Institute AB, Bergshamra Allé 9, SE-170 77 Solna, Sweden. marie.loden@eviderm.se

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22507043

Citation

Lodén, Marie. "Effect of Moisturizers On Epidermal Barrier Function." Clinics in Dermatology, vol. 30, no. 3, 2012, pp. 286-96.
Lodén M. Effect of moisturizers on epidermal barrier function. Clin Dermatol. 2012;30(3):286-96.
Lodén, M. (2012). Effect of moisturizers on epidermal barrier function. Clinics in Dermatology, 30(3), 286-96. https://doi.org/10.1016/j.clindermatol.2011.08.015
Lodén M. Effect of Moisturizers On Epidermal Barrier Function. Clin Dermatol. 2012 May-Jun;30(3):286-96. PubMed PMID: 22507043.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of moisturizers on epidermal barrier function. A1 - Lodén,Marie, PY - 2012/4/18/entrez PY - 2012/4/18/pubmed PY - 2012/8/24/medline SP - 286 EP - 96 JF - Clinics in dermatology JO - Clin Dermatol VL - 30 IS - 3 N2 - A daily moisturizing routine is a vital part of the management of patients with atopic dermatitis and other dry skin conditions. The composition of the moisturizer determines whether the treatment strengthens or deteriorates the skin barrier function, which may have consequences for the outcome of the dermatitis. One might expect that a patient's impaired skin barrier function should improve in association with a reduction in the clinical signs of dryness. Despite visible relief of the dryness symptoms, however, the abnormal transepidermal water loss has been reported to remain high, or even to increase under certain regimens, whereas other moisturizers improve skin barrier function. Differing outcomes have also been reported in healthy skin: some moisturizers produce deterioration in skin barrier function and others improve the skin. Possible targets for barrier-influencing moisturizing creams include the intercellular lipid bilayers, where the fraction of lipids forming a fluid phase might be changed due to compositional or organizational changes. Other targets are the projected size of the corneocytes or the thickness of the stratum corneum. Moisturizers with barrier-improving properties may delay relapse of dermatitis in patients with atopic dermatitis. In a worst-case scenario, treatment with moisturizing creams could increase the risks of dermatitis and asthma. SN - 1879-1131 UR - https://www.unboundmedicine.com/medline/citation/22507043/Effect_of_moisturizers_on_epidermal_barrier_function_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0738-081X(11)00219-7 DB - PRIME DP - Unbound Medicine ER -