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An analysis of the relative risk for hypothyroidism in patients with Type 2 diabetes.

Abstract

AIMS

We aimed to assess the relative risk for hypothyroidism in patients with Type 2 diabetes.

METHODS

In this study, 1112 patients with Type 2 diabetes (58% women, mean age 66.7 years, median duration of diabetes 10 years, 179 with previous history of thyroid disease) and 911 subjects without diabetes were evaluated.

RESULTS

The gender-, age- and weight-adjusted relative risk (odds ratio) of newly identified hypothyroidism in patients with Type 2 diabetes in comparison with control subjects was 2.81 (1.77-4.48). This odds ratio was significant in patients over 65 years [4.02 (1.95-8.31)], as well as in both men [4.84 (1.58-14.80)] and women [2.60 (1.54-4.38)], in obese patients [2.56 (1.36-4.82)] and non-obese patients [3.11 (1.56-6.20)] and in individuals with [4.26 (1.73-10.46)] and without [2.93 (1.50-5.75)] thyroid autoantibodies. Logistic regression analysis showed that newly diagnosed hypothyroidism was significantly and directly related not only with thyroid autoimmunity [19.15 (8.73-42.01)], but also with the presence of macroangiopathy [2.85 (1.51-5.35)] and metformin treatment [2.51 (1.28-4.92)].

CONCLUSIONS

Our results favour screening for hypothyroidism in patients with Type 2 diabetes older than 65 years, especially in the presence of diabetic macroangiopathy or treatment with metformin.

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    Authors+Show Affiliations

    Díez JJ
    ,

    Department of Endocrinology, Hospital Ramón y Cajal, Madrid, Spain. jdiez.hrc@salud.madrid.org

    Iglesias P

    Source

    MeSH

    Aged
    Autoantibodies
    Diabetes Mellitus, Type 2
    Fasting
    Female
    Humans
    Hypoglycemic Agents
    Hypothyroidism
    Logistic Models
    Male
    Metformin
    Odds Ratio
    Prevalence
    Risk
    Thyrotropin
    Thyroxine

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    22507223

    Citation

    Díez, J J., and P Iglesias. "An Analysis of the Relative Risk for Hypothyroidism in Patients With Type 2 Diabetes." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 29, no. 12, 2012, pp. 1510-4.
    Díez JJ, Iglesias P. An analysis of the relative risk for hypothyroidism in patients with Type 2 diabetes. Diabet Med. 2012;29(12):1510-4.
    Díez, J. J., & Iglesias, P. (2012). An analysis of the relative risk for hypothyroidism in patients with Type 2 diabetes. Diabetic Medicine : a Journal of the British Diabetic Association, 29(12), pp. 1510-4. doi:10.1111/j.1464-5491.2012.03687.x.
    Díez JJ, Iglesias P. An Analysis of the Relative Risk for Hypothyroidism in Patients With Type 2 Diabetes. Diabet Med. 2012;29(12):1510-4. PubMed PMID: 22507223.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - An analysis of the relative risk for hypothyroidism in patients with Type 2 diabetes. AU - Díez,J J, AU - Iglesias,P, PY - 2012/4/18/entrez PY - 2012/4/18/pubmed PY - 2013/5/18/medline SP - 1510 EP - 4 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 29 IS - 12 N2 - AIMS: We aimed to assess the relative risk for hypothyroidism in patients with Type 2 diabetes. METHODS: In this study, 1112 patients with Type 2 diabetes (58% women, mean age 66.7 years, median duration of diabetes 10 years, 179 with previous history of thyroid disease) and 911 subjects without diabetes were evaluated. RESULTS: The gender-, age- and weight-adjusted relative risk (odds ratio) of newly identified hypothyroidism in patients with Type 2 diabetes in comparison with control subjects was 2.81 (1.77-4.48). This odds ratio was significant in patients over 65 years [4.02 (1.95-8.31)], as well as in both men [4.84 (1.58-14.80)] and women [2.60 (1.54-4.38)], in obese patients [2.56 (1.36-4.82)] and non-obese patients [3.11 (1.56-6.20)] and in individuals with [4.26 (1.73-10.46)] and without [2.93 (1.50-5.75)] thyroid autoantibodies. Logistic regression analysis showed that newly diagnosed hypothyroidism was significantly and directly related not only with thyroid autoimmunity [19.15 (8.73-42.01)], but also with the presence of macroangiopathy [2.85 (1.51-5.35)] and metformin treatment [2.51 (1.28-4.92)]. CONCLUSIONS: Our results favour screening for hypothyroidism in patients with Type 2 diabetes older than 65 years, especially in the presence of diabetic macroangiopathy or treatment with metformin. SN - 1464-5491 UR - https://www.unboundmedicine.com/medline/citation/22507223/full_citation L2 - https://doi.org/10.1111/j.1464-5491.2012.03687.x DB - PRIME DP - Unbound Medicine ER -