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Serum folate, total homocysteine levels and methylenetetrahydrofolate reductase 677C>T polymorphism in young healthy female Japanese.
Asia Pac J Clin Nutr. 2012; 21(2):291-5.AP

Abstract

Environmental and genetic factors influence serum total homocysteine (tHcy), a risk factor for vascular diseases. The gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) is reported to be a genetic factor for influencing tHcy. However, it is not clear whether MTHFR polymorphism influences tHcy in the younger generation. To investigate the influence of MTHFR polymorphism on vascular disease risks in young Japanese females, we determined dietary intakes, serum folate and tHcy, and examined the influence of MTHFR 677C>T polymorphism in healthy junior and high school students (n=192, 12-18y). The relationships between MTHFR polymorphism and folate intake, serum folate or tHcy were investigated by dividing participants into CC, CT and TT types. Among individuals with the TT genotype, folate and tHcy levels were significantly lower (p<0.05) or higher (p<0.0001), respectively, than in those with the other genotypes; although there were no significant differences in the intake of folate among genotypes. In addition, a significant inverse correlation between folate and tHcy (p<0.05) was noted in all genotypes, even in young females, so far not examined in Asian populations. Therefore, MTHFR genotypes were proven to be a significant determinant for folate and tHcy concentrations. However, the association of increased folate intake with lower tHcy concentration, even in cases of the mutation TT type, indicates the importance of folate intake in young Japanese females for early detection of risk, as well as the prevention of vascular diseases.

Authors+Show Affiliations

Mukogawa Women's University, Institute for World Health Development, Nishinomiya, Hyogo, Japan. ttaguchi@mukogawa-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22507617

Citation

Taguchi, Takashi, et al. "Serum Folate, Total Homocysteine Levels and Methylenetetrahydrofolate Reductase 677C>T Polymorphism in Young Healthy Female Japanese." Asia Pacific Journal of Clinical Nutrition, vol. 21, no. 2, 2012, pp. 291-5.
Taguchi T, Mori H, Hamada A, et al. Serum folate, total homocysteine levels and methylenetetrahydrofolate reductase 677C>T polymorphism in young healthy female Japanese. Asia Pac J Clin Nutr. 2012;21(2):291-5.
Taguchi, T., Mori, H., Hamada, A., Yamori, Y., & Mori, M. (2012). Serum folate, total homocysteine levels and methylenetetrahydrofolate reductase 677C>T polymorphism in young healthy female Japanese. Asia Pacific Journal of Clinical Nutrition, 21(2), 291-5.
Taguchi T, et al. Serum Folate, Total Homocysteine Levels and Methylenetetrahydrofolate Reductase 677C>T Polymorphism in Young Healthy Female Japanese. Asia Pac J Clin Nutr. 2012;21(2):291-5. PubMed PMID: 22507617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum folate, total homocysteine levels and methylenetetrahydrofolate reductase 677C>T polymorphism in young healthy female Japanese. AU - Taguchi,Takashi, AU - Mori,Hideki, AU - Hamada,Atsumi, AU - Yamori,Yukio, AU - Mori,Mari, PY - 2012/4/18/entrez PY - 2012/4/18/pubmed PY - 2012/5/25/medline SP - 291 EP - 5 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 21 IS - 2 N2 - Environmental and genetic factors influence serum total homocysteine (tHcy), a risk factor for vascular diseases. The gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) is reported to be a genetic factor for influencing tHcy. However, it is not clear whether MTHFR polymorphism influences tHcy in the younger generation. To investigate the influence of MTHFR polymorphism on vascular disease risks in young Japanese females, we determined dietary intakes, serum folate and tHcy, and examined the influence of MTHFR 677C>T polymorphism in healthy junior and high school students (n=192, 12-18y). The relationships between MTHFR polymorphism and folate intake, serum folate or tHcy were investigated by dividing participants into CC, CT and TT types. Among individuals with the TT genotype, folate and tHcy levels were significantly lower (p<0.05) or higher (p<0.0001), respectively, than in those with the other genotypes; although there were no significant differences in the intake of folate among genotypes. In addition, a significant inverse correlation between folate and tHcy (p<0.05) was noted in all genotypes, even in young females, so far not examined in Asian populations. Therefore, MTHFR genotypes were proven to be a significant determinant for folate and tHcy concentrations. However, the association of increased folate intake with lower tHcy concentration, even in cases of the mutation TT type, indicates the importance of folate intake in young Japanese females for early detection of risk, as well as the prevention of vascular diseases. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/22507617/Serum_folate_total_homocysteine_levels_and_methylenetetrahydrofolate_reductase_677C>T_polymorphism_in_young_healthy_female_Japanese_ L2 - http://apjcn.nhri.org.tw/server/APJCN/21/2/291.pdf DB - PRIME DP - Unbound Medicine ER -