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Alternative procedure to allow continuation of dapsone therapy despite serious adverse reaction in a case of dapsone-sensitive erythema elevatum diutinum.
Dermatology. 2012; 224(2):115-9.D

Abstract

Dapsone has potent anti-inflammatory effects and remains an effective therapy in a variety of skin disorders: cutaneous vasculitis, neutrophilic dermatoses and blistering disorders. However it may cause a severe idiosyncratic reaction compatible with drug-induced DRESS (drug reaction with eosinophilia and systemic symptoms) leading to the discontinuation of the treatment despite its effectiveness. We report a 68-year-old woman who was successfully treated with dapsone for erythema elevatum diutinum. However she developed a hypersensitivity syndrome compatible with DRESS with fever, skin rash and acute hepatitis confirmed in vitro by the presence of circulating dapsone- specific T cells. Dapsone therapy was suspended, leading to a relapse of erythema elevatum diutinum. While alternative therapies were totally ineffective in our patient to improve her skin condition, we proposed a tolerance induction protocol to dapsone with excellent results.

Authors+Show Affiliations

Department of Dermatology and Pediatric Dermatology, Saint André and Pellegrin Hospitals, Bordeaux University Hospitals, Bordeaux, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

22508198

Citation

Seneschal, Julien, et al. "Alternative Procedure to Allow Continuation of Dapsone Therapy Despite Serious Adverse Reaction in a Case of Dapsone-sensitive Erythema Elevatum Diutinum." Dermatology (Basel, Switzerland), vol. 224, no. 2, 2012, pp. 115-9.
Seneschal J, Guillet S, Ezzedine K, et al. Alternative procedure to allow continuation of dapsone therapy despite serious adverse reaction in a case of dapsone-sensitive erythema elevatum diutinum. Dermatology. 2012;224(2):115-9.
Seneschal, J., Guillet, S., Ezzedine, K., Taïeb, A., & Milpied, B. (2012). Alternative procedure to allow continuation of dapsone therapy despite serious adverse reaction in a case of dapsone-sensitive erythema elevatum diutinum. Dermatology (Basel, Switzerland), 224(2), 115-9. https://doi.org/10.1159/000337424
Seneschal J, et al. Alternative Procedure to Allow Continuation of Dapsone Therapy Despite Serious Adverse Reaction in a Case of Dapsone-sensitive Erythema Elevatum Diutinum. Dermatology. 2012;224(2):115-9. PubMed PMID: 22508198.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alternative procedure to allow continuation of dapsone therapy despite serious adverse reaction in a case of dapsone-sensitive erythema elevatum diutinum. AU - Seneschal,Julien, AU - Guillet,Stéphanie, AU - Ezzedine,Khaled, AU - Taïeb,Alain, AU - Milpied,Brigitte, Y1 - 2012/04/12/ PY - 2011/11/11/received PY - 2012/02/08/accepted PY - 2012/4/18/entrez PY - 2012/4/18/pubmed PY - 2012/10/4/medline SP - 115 EP - 9 JF - Dermatology (Basel, Switzerland) JO - Dermatology VL - 224 IS - 2 N2 - Dapsone has potent anti-inflammatory effects and remains an effective therapy in a variety of skin disorders: cutaneous vasculitis, neutrophilic dermatoses and blistering disorders. However it may cause a severe idiosyncratic reaction compatible with drug-induced DRESS (drug reaction with eosinophilia and systemic symptoms) leading to the discontinuation of the treatment despite its effectiveness. We report a 68-year-old woman who was successfully treated with dapsone for erythema elevatum diutinum. However she developed a hypersensitivity syndrome compatible with DRESS with fever, skin rash and acute hepatitis confirmed in vitro by the presence of circulating dapsone- specific T cells. Dapsone therapy was suspended, leading to a relapse of erythema elevatum diutinum. While alternative therapies were totally ineffective in our patient to improve her skin condition, we proposed a tolerance induction protocol to dapsone with excellent results. SN - 1421-9832 UR - https://www.unboundmedicine.com/medline/citation/22508198/Alternative_procedure_to_allow_continuation_of_dapsone_therapy_despite_serious_adverse_reaction_in_a_case_of_dapsone_sensitive_erythema_elevatum_diutinum_ L2 - https://www.karger.com?DOI=10.1159/000337424 DB - PRIME DP - Unbound Medicine ER -