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Antiobesity effects of Chinese black tea (Pu-erh tea) extract and gallic acid.
Phytother Res. 2012 Apr; 26(4):475-81.PR

Abstract

The antiobesity effects of Chinese black tea (Pu-erh tea) and of gallic acid (GA) were investigated using in vitro and in vivo assays. Chinese black tea extract (BTE) and GA inhibited pancreatic lipase activity in a dose-dependent manner in vitro; the IC(inhibitory concentration)(50) values were 101.6 and 9.2 µg/mL, respectively. Black tea extract (50, 100 mg/kg body weight (b.w.)) and GA (15, 45 mg/kg b.w.) significantly suppressed the elevation of blood triglyceride after oral administration of a corn oil emulsion (8 mL oil/kg b.w.) to male ddY mice. Moreover, the antiobesity effects of BTE and GA were also evaluated in a mouse model of diet-induced obesity. Female ddY mice were divided into seven groups; normal diet (ND) group, high fat diet (HFD) group, BTE (0.2% and 0.6% of diets) groups, and GA (0.007%, 0.02% and 0.1% of diets) groups; the experimental groups were fed the test diets for 12 weeks. The BTE 0.6% and GA 0.1% groups showed significant suppression of weight gain. The weight of parametrial adipose tissue was strongly correlated with the body weight. These results suggest that GA contributes to the antiobesity effect of BTE as an active constituent by inhibiting pancreatic lipase activity.

Authors+Show Affiliations

Research and Development Department, Nippon Supplement, Inc., 19-19, Chayamachi, Kita-Ku, Osaka, 530-0013, Japan. oi@nippon-sapuri.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22508359

Citation

Oi, Yasuyuki, et al. "Antiobesity Effects of Chinese Black Tea (Pu-erh Tea) Extract and Gallic Acid." Phytotherapy Research : PTR, vol. 26, no. 4, 2012, pp. 475-81.
Oi Y, Hou IC, Fujita H, et al. Antiobesity effects of Chinese black tea (Pu-erh tea) extract and gallic acid. Phytother Res. 2012;26(4):475-81.
Oi, Y., Hou, I. C., Fujita, H., & Yazawa, K. (2012). Antiobesity effects of Chinese black tea (Pu-erh tea) extract and gallic acid. Phytotherapy Research : PTR, 26(4), 475-81. https://doi.org/10.1002/ptr.3602
Oi Y, et al. Antiobesity Effects of Chinese Black Tea (Pu-erh Tea) Extract and Gallic Acid. Phytother Res. 2012;26(4):475-81. PubMed PMID: 22508359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiobesity effects of Chinese black tea (Pu-erh tea) extract and gallic acid. AU - Oi,Yasuyuki, AU - Hou,I-Ching, AU - Fujita,Hiroyuki, AU - Yazawa,Kazunaga, Y1 - 2011/08/16/ PY - 2010/11/26/received PY - 2011/05/27/revised PY - 2011/05/27/accepted PY - 2012/4/18/entrez PY - 2012/4/18/pubmed PY - 2012/8/15/medline SP - 475 EP - 81 JF - Phytotherapy research : PTR JO - Phytother Res VL - 26 IS - 4 N2 - The antiobesity effects of Chinese black tea (Pu-erh tea) and of gallic acid (GA) were investigated using in vitro and in vivo assays. Chinese black tea extract (BTE) and GA inhibited pancreatic lipase activity in a dose-dependent manner in vitro; the IC(inhibitory concentration)(50) values were 101.6 and 9.2 µg/mL, respectively. Black tea extract (50, 100 mg/kg body weight (b.w.)) and GA (15, 45 mg/kg b.w.) significantly suppressed the elevation of blood triglyceride after oral administration of a corn oil emulsion (8 mL oil/kg b.w.) to male ddY mice. Moreover, the antiobesity effects of BTE and GA were also evaluated in a mouse model of diet-induced obesity. Female ddY mice were divided into seven groups; normal diet (ND) group, high fat diet (HFD) group, BTE (0.2% and 0.6% of diets) groups, and GA (0.007%, 0.02% and 0.1% of diets) groups; the experimental groups were fed the test diets for 12 weeks. The BTE 0.6% and GA 0.1% groups showed significant suppression of weight gain. The weight of parametrial adipose tissue was strongly correlated with the body weight. These results suggest that GA contributes to the antiobesity effect of BTE as an active constituent by inhibiting pancreatic lipase activity. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/22508359/Antiobesity_effects_of_Chinese_black_tea__Pu_erh_tea__extract_and_gallic_acid_ L2 - https://doi.org/10.1002/ptr.3602 DB - PRIME DP - Unbound Medicine ER -