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Cerebral ganglioneuroblastoma of adult onset: two patients and a review of the literature.

Abstract

Ganglioneuroblastoma is a rare tumor variant of neuroblastoma. Only five cases have been observed in the adult brain, and we report here on two more adult patients with cerebral ganglioneuroblastoma. Additionally, a review was carried out on all 50 published adult cases with ganglioneuroblastoma, located in the adrenal gland (9), mediastinum (8), retroperitoneal area (7), the brain parenchyma (7), or the spinal cord (3). Median age at onset was 39 years, and 52% of patients were female. For extracranial locations, treatment usually consisted of surgery followed by radiotherapy and adjuvant chemotherapy. Of the cases with cerebral involvement only one patient did not receive any treatment. The other six patients underwent surgical resection and radiation therapy, in four cases followed by chemotherapy with temozolomide. The median survival of cerebral ganglioneuroblastomas was 14 months and did not differ from the whole group of ganglioneuroblastomas (12 months). For cerebral ganglioneuroblastoma, the preferred regimen would seem to be neurosurgical removal, followed by chemoradiotherapy including temozolomide.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, Medical Center Haaglanden, The Hague, The Netherlands. m.h.schipper@mchaaglanden.nl

    , , , , ,

    Source

    Clinical neurology and neurosurgery 114:6 2012 Jul pg 529-34

    MeSH

    Adult
    Age of Onset
    Antineoplastic Agents, Alkylating
    Brain
    Brain Neoplasms
    Chemoradiotherapy
    Chemotherapy, Adjuvant
    Dacarbazine
    Female
    Ganglioneuroblastoma
    Humans
    Magnetic Resonance Imaging
    Male
    Neurosurgical Procedures
    Temozolomide
    Tomography, X-Ray Computed

    Pub Type(s)

    Case Reports
    Journal Article
    Review

    Language

    eng

    PubMed ID

    22510501

    Citation

    Schipper, Mirjam H., et al. "Cerebral Ganglioneuroblastoma of Adult Onset: Two Patients and a Review of the Literature." Clinical Neurology and Neurosurgery, vol. 114, no. 6, 2012, pp. 529-34.
    Schipper MH, van Duinen SG, Taphoorn MJ, et al. Cerebral ganglioneuroblastoma of adult onset: two patients and a review of the literature. Clin Neurol Neurosurg. 2012;114(6):529-34.
    Schipper, M. H., van Duinen, S. G., Taphoorn, M. J., Kloet, A., Walchenbach, R., Wiggenraad, R. G., & Vecht, C. J. (2012). Cerebral ganglioneuroblastoma of adult onset: two patients and a review of the literature. Clinical Neurology and Neurosurgery, 114(6), pp. 529-34. doi:10.1016/j.clineuro.2012.03.015.
    Schipper MH, et al. Cerebral Ganglioneuroblastoma of Adult Onset: Two Patients and a Review of the Literature. Clin Neurol Neurosurg. 2012;114(6):529-34. PubMed PMID: 22510501.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cerebral ganglioneuroblastoma of adult onset: two patients and a review of the literature. AU - Schipper,Mirjam H, AU - van Duinen,Sjoerd G, AU - Taphoorn,Martin J, AU - Kloet,Alfred, AU - Walchenbach,Robert, AU - Wiggenraad,Ruud G, AU - Vecht,Charles J, Y1 - 2012/04/15/ PY - 2012/01/12/received PY - 2012/02/27/revised PY - 2012/03/06/accepted PY - 2012/4/19/entrez PY - 2012/4/19/pubmed PY - 2012/10/17/medline SP - 529 EP - 34 JF - Clinical neurology and neurosurgery JO - Clin Neurol Neurosurg VL - 114 IS - 6 N2 - Ganglioneuroblastoma is a rare tumor variant of neuroblastoma. Only five cases have been observed in the adult brain, and we report here on two more adult patients with cerebral ganglioneuroblastoma. Additionally, a review was carried out on all 50 published adult cases with ganglioneuroblastoma, located in the adrenal gland (9), mediastinum (8), retroperitoneal area (7), the brain parenchyma (7), or the spinal cord (3). Median age at onset was 39 years, and 52% of patients were female. For extracranial locations, treatment usually consisted of surgery followed by radiotherapy and adjuvant chemotherapy. Of the cases with cerebral involvement only one patient did not receive any treatment. The other six patients underwent surgical resection and radiation therapy, in four cases followed by chemotherapy with temozolomide. The median survival of cerebral ganglioneuroblastomas was 14 months and did not differ from the whole group of ganglioneuroblastomas (12 months). For cerebral ganglioneuroblastoma, the preferred regimen would seem to be neurosurgical removal, followed by chemoradiotherapy including temozolomide. SN - 1872-6968 UR - https://www.unboundmedicine.com/medline/citation/22510501/Cerebral_ganglioneuroblastoma_of_adult_onset:_two_patients_and_a_review_of_the_literature_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-8467(12)00167-9 DB - PRIME DP - Unbound Medicine ER -