Tags

Type your tag names separated by a space and hit enter

International results with the Boston type I keratoprosthesis.
Ophthalmology 2012; 119(8):1530-8O

Abstract

PURPOSE

To determine the indications and outcomes of Boston type 1 keratoprosthesis (Massachusetts Eye and Ear Infirmary, Boston, MA) surgery performed outside of North America and to compare them with those obtained in the United States by the surgeon who trained the international surgeons.

DESIGN

Retrospective review of consecutive clinical case series.

PARTICIPANTS

One hundred ninety-four patients (223 keratoprosthesis procedures performed in 205 eyes) who received Boston type 1 keratoprosthesis at 11 ophthalmology centers in Armenia, India, Indonesia, Nepal, Philippines, Russia, and Saudi Arabia between May 1, 2006, and July 1, 2011 (international series), and at the Jules Stein Eye Institute between May 1, 2004, and July 1, 2011 (University of California, Los Angeles [UCLA] series).

METHODS

Data were collected for each procedure regarding the preoperative characteristics of each eye, the surgical procedure(s) performed, and the postoperative outcomes. Statistical analysis was performed to identify significant differences between the international and UCLA series in terms of retention and complications.

MAIN OUTCOME MEASURES

Interval visual acuities, keratoprosthesis retention, and significant postoperative complications.

RESULTS

In the international series, 113 Boston type I keratoprostheses were implanted in 107 eyes of 100 patients. The most common indication for surgery was corneal graft failure (n = 50; 44%) followed by chemical injury (n = 30; 27%). Although only 2% of eyes had a preoperative corrected distance visual acuity (CDVA) of 20/20 to 20/200, 70%, 68%, and 59% of eyes had a postoperative CDVA of 20/20 to 20/200 at 6 months, 1 year, and 2 years after surgery, respectively. Ninety-one of the 113 keratoprostheses implanted (80.5%) were retained at a mean follow-up of 14.2 months, for a retention failure rate of 22 per 134.6 eye-years (0.163/eye-year). The most common postoperative complications were retroprosthetic membrane formation (27%) and sterile corneal necrosis (18%). The only postoperative complication that was more common in the international series than in the UCLA series was infectious endophthalmitis, which developed in 9% of eyes.

CONCLUSIONS

Boston keratoprosthesis is a viable means of managing repeat graft failure and ocular chemical injury outside of North America, with similar visual acuity outcomes, retention rates, and incidence rates of postoperative complications to those obtained by North American surgeons.

Authors+Show Affiliations

The Jules Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA. aldave@jsei.ucla.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

22512986

Citation

Aldave, Anthony J., et al. "International Results With the Boston Type I Keratoprosthesis." Ophthalmology, vol. 119, no. 8, 2012, pp. 1530-8.
Aldave AJ, Sangwan VS, Basu S, et al. International results with the Boston type I keratoprosthesis. Ophthalmology. 2012;119(8):1530-8.
Aldave, A. J., Sangwan, V. S., Basu, S., Basak, S. K., Hovakimyan, A., Gevorgyan, O., ... Yu, F. (2012). International results with the Boston type I keratoprosthesis. Ophthalmology, 119(8), pp. 1530-8. doi:10.1016/j.ophtha.2012.02.015.
Aldave AJ, et al. International Results With the Boston Type I Keratoprosthesis. Ophthalmology. 2012;119(8):1530-8. PubMed PMID: 22512986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - International results with the Boston type I keratoprosthesis. AU - Aldave,Anthony J, AU - Sangwan,Virender S, AU - Basu,Sayan, AU - Basak,Samar K, AU - Hovakimyan,Anna, AU - Gevorgyan,Ofelya, AU - Kharashi,Soliman Al, AU - Jindan,Mohanna Al, AU - Tandon,Radhika, AU - Mascarenhas,Jeena, AU - Malyugin,Boris, AU - Padilla,Ma Dominga B, AU - Maskati,Quresh, AU - Agarwala,Nisheeta, AU - Hutauruk,Johan, AU - Sharma,Manoj, AU - Yu,Fei, Y1 - 2012/04/17/ PY - 2011/12/19/received PY - 2012/01/23/revised PY - 2012/02/08/accepted PY - 2012/4/20/entrez PY - 2012/4/20/pubmed PY - 2012/10/26/medline SP - 1530 EP - 8 JF - Ophthalmology JO - Ophthalmology VL - 119 IS - 8 N2 - PURPOSE: To determine the indications and outcomes of Boston type 1 keratoprosthesis (Massachusetts Eye and Ear Infirmary, Boston, MA) surgery performed outside of North America and to compare them with those obtained in the United States by the surgeon who trained the international surgeons. DESIGN: Retrospective review of consecutive clinical case series. PARTICIPANTS: One hundred ninety-four patients (223 keratoprosthesis procedures performed in 205 eyes) who received Boston type 1 keratoprosthesis at 11 ophthalmology centers in Armenia, India, Indonesia, Nepal, Philippines, Russia, and Saudi Arabia between May 1, 2006, and July 1, 2011 (international series), and at the Jules Stein Eye Institute between May 1, 2004, and July 1, 2011 (University of California, Los Angeles [UCLA] series). METHODS: Data were collected for each procedure regarding the preoperative characteristics of each eye, the surgical procedure(s) performed, and the postoperative outcomes. Statistical analysis was performed to identify significant differences between the international and UCLA series in terms of retention and complications. MAIN OUTCOME MEASURES: Interval visual acuities, keratoprosthesis retention, and significant postoperative complications. RESULTS: In the international series, 113 Boston type I keratoprostheses were implanted in 107 eyes of 100 patients. The most common indication for surgery was corneal graft failure (n = 50; 44%) followed by chemical injury (n = 30; 27%). Although only 2% of eyes had a preoperative corrected distance visual acuity (CDVA) of 20/20 to 20/200, 70%, 68%, and 59% of eyes had a postoperative CDVA of 20/20 to 20/200 at 6 months, 1 year, and 2 years after surgery, respectively. Ninety-one of the 113 keratoprostheses implanted (80.5%) were retained at a mean follow-up of 14.2 months, for a retention failure rate of 22 per 134.6 eye-years (0.163/eye-year). The most common postoperative complications were retroprosthetic membrane formation (27%) and sterile corneal necrosis (18%). The only postoperative complication that was more common in the international series than in the UCLA series was infectious endophthalmitis, which developed in 9% of eyes. CONCLUSIONS: Boston keratoprosthesis is a viable means of managing repeat graft failure and ocular chemical injury outside of North America, with similar visual acuity outcomes, retention rates, and incidence rates of postoperative complications to those obtained by North American surgeons. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/22512986/International_results_with_the_Boston_type_I_keratoprosthesis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(12)00135-2 DB - PRIME DP - Unbound Medicine ER -