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Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids.
Prostaglandins Leukot Essent Fatty Acids. 2013 Jan; 88(1):139-46.PL

Abstract

The conversion of the plant-derived omega-3 (n-3) α-linolenic acid (ALA, 18:3n-3) to the long-chain eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) can be increased by ALA sufficient diets compared to ALA deficient diets. Diets containing ALA above an optimal level result in no further increase in DHA levels in animals and humans. The present study evaluates means of maximizing plasma DHA accumulation by systematically varying both linoleic acid (LA, 18:2n-6) and ALA dietary level. Weanling rats were fed one of 54 diets for three weeks. The diets varied in the percentage of energy (en%) of LA (0.07-17.1 en%) and ALA (0.02-12.1 en%) by manipulating both the fat content and the balance of vegetable oils. The peak of plasma phospholipid DHA (>8% total fatty acids) was attained as a result of feeding a narrow dietary range of 1-3 en% ALA and 1-2 en% LA but was suppressed to basal levels (∼2% total fatty acids) at dietary intakes of total polyunsaturated fatty acids (PUFA) above 3 en%. We conclude it is possible to enhance the DHA status of rats fed diets containing ALA as the only source of n-3 fatty acids but only when the level of dietary PUFA is low (<3 en%).

Authors+Show Affiliations

FOODplus Research Centre, School of Agriculture, Food and Wine, The University of Adelaide, South Australia, Australia. robert.gibson@adelaide.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22515943

Citation

Gibson, R A., et al. "Docosahexaenoic Acid Synthesis From Alpha-linolenic Acid Is Inhibited By Diets High in Polyunsaturated Fatty Acids." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 88, no. 1, 2013, pp. 139-46.
Gibson RA, Neumann MA, Lien EL, et al. Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. Prostaglandins Leukot Essent Fatty Acids. 2013;88(1):139-46.
Gibson, R. A., Neumann, M. A., Lien, E. L., Boyd, K. A., & Tu, W. C. (2013). Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 88(1), 139-46. https://doi.org/10.1016/j.plefa.2012.04.003
Gibson RA, et al. Docosahexaenoic Acid Synthesis From Alpha-linolenic Acid Is Inhibited By Diets High in Polyunsaturated Fatty Acids. Prostaglandins Leukot Essent Fatty Acids. 2013;88(1):139-46. PubMed PMID: 22515943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. AU - Gibson,R A, AU - Neumann,M A, AU - Lien,E L, AU - Boyd,K A, AU - Tu,W C, Y1 - 2012/04/17/ PY - 2012/01/11/received PY - 2012/04/02/revised PY - 2012/04/03/accepted PY - 2012/4/21/entrez PY - 2012/4/21/pubmed PY - 2013/7/5/medline SP - 139 EP - 46 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 88 IS - 1 N2 - The conversion of the plant-derived omega-3 (n-3) α-linolenic acid (ALA, 18:3n-3) to the long-chain eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) can be increased by ALA sufficient diets compared to ALA deficient diets. Diets containing ALA above an optimal level result in no further increase in DHA levels in animals and humans. The present study evaluates means of maximizing plasma DHA accumulation by systematically varying both linoleic acid (LA, 18:2n-6) and ALA dietary level. Weanling rats were fed one of 54 diets for three weeks. The diets varied in the percentage of energy (en%) of LA (0.07-17.1 en%) and ALA (0.02-12.1 en%) by manipulating both the fat content and the balance of vegetable oils. The peak of plasma phospholipid DHA (>8% total fatty acids) was attained as a result of feeding a narrow dietary range of 1-3 en% ALA and 1-2 en% LA but was suppressed to basal levels (∼2% total fatty acids) at dietary intakes of total polyunsaturated fatty acids (PUFA) above 3 en%. We conclude it is possible to enhance the DHA status of rats fed diets containing ALA as the only source of n-3 fatty acids but only when the level of dietary PUFA is low (<3 en%). SN - 1532-2823 UR - https://www.unboundmedicine.com/medline/citation/22515943/Docosahexaenoic_acid_synthesis_from_alpha_linolenic_acid_is_inhibited_by_diets_high_in_polyunsaturated_fatty_acids_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(12)00058-0 DB - PRIME DP - Unbound Medicine ER -