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Treatment of motor and non-motor features of Parkinson's disease with deep brain stimulation.


Deep brain stimulation (DBS) is an established procedure for the symptomatic treatment of Parkinson's disease. Several deep brain nuclei have been stimulated, producing a wide range of effects on the motor and non-motor symptoms of Parkinson's disease. Long-term, high-quality evidence is available for stimulation of the subthalamic nucleus and globus pallidus internus, both of which uniformly improve motor features, and for stimulation of the thalamic ventralis intermedius, which improves tremor. Short-term data are available for stimulation of other deep brain targets, such as the pedunculopontine nucleus and the centremedian/parafascicular thalamic complex. Some non-motor symptoms improve after DBS, partly because of motor benefit or reduction of drug treatment, and partly as a direct effect of stimulation. More evidence on the effects of DBS on non-motor symptoms is needed and specifically designed studies are warranted.


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  • Authors+Show Affiliations


    Istituto di Neurologia, Università Cattolica del Sacro Cuore, Rome, Italy.



    The Lancet. Neurology 11:5 2012 May pg 429-42


    Basal Ganglia
    Brain Mapping
    Deep Brain Stimulation
    Disability Evaluation
    Disease Progression
    Efferent Pathways
    Follow-Up Studies
    Globus Pallidus
    Intralaminar Thalamic Nuclei
    Magnetic Resonance Imaging
    Mental Disorders
    Motor Activity
    Motor Skills
    Neurologic Examination
    Parkinson Disease
    Pedunculopontine Tegmental Nucleus
    Quality of Life
    Speech Disorders
    Subthalamic Nucleus
    Ventral Thalamic Nuclei

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't



    PubMed ID