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Hemoglobin Level Adds Prognostic Value to the Global Registry of Acute Coronary Events Score in Non-ST Elevation Acute Coronary Syndromes.
Cardiology. 2012; 121(4):213-9.C

Abstract

OBJECTIVE

We aimed to test the hypothesis that hemoglobin values add prognostic information to the Global Registry of Acute Coronary Events (GRACE) score at admission in patients with non-ST elevation acute coronary syndromes (ACS).

METHODS

A total of 225 consecutive patients with non-ST elevation ACS were studied. Hemoglobin was measured at admission, and its prognostic value was evaluated in relation to cardiovascular events during hospitalization, defined as the composite of death or myocardial infarction.

RESULTS

The incidence of major in-hospital events was 7% (10 deaths and 5 nonfatal myocardial infarctions). Hemoglobin significantly predicted events, with a C statistic of 0.67 [95% confidence interval (CI) 0.53-0.81; p = 0.03], with 12.1 g/dl as the cutoff point of best performance. After adjustment for the GRACE score, low hemoglobin (≤12.1 g/dl) remained an independent predictor of events (odds ratio 3.9, 95% CI 1.2-13; p = 0.028). The C statistic of the GRACE score for prediction of events improved from 0.80 to 0.84 after hemoglobin was taken into account. Finally, the addition of hemoglobin to the GRACE score promoted a net reclassification improvement of 16% in identifying high-risk patients (p = 0.025).

CONCLUSIONS

The present study provides preliminary evidence that hemoglobin level independently predicts recurrent events during hospitalization and improves the prognostic performance of the GRACE score in patients with non-ST elevation ACS.

Authors+Show Affiliations

Medical School of Bahia, Salvador, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22516872

Citation

Correia, Luis C L., et al. "Hemoglobin Level Adds Prognostic Value to the Global Registry of Acute Coronary Events Score in Non-ST Elevation Acute Coronary Syndromes." Cardiology, vol. 121, no. 4, 2012, pp. 213-9.
Correia LC, Souza AC, Sabino M, et al. Hemoglobin Level Adds Prognostic Value to the Global Registry of Acute Coronary Events Score in Non-ST Elevation Acute Coronary Syndromes. Cardiology. 2012;121(4):213-9.
Correia, L. C., Souza, A. C., Sabino, M., Brito, M., Maraux, M., Garcia, G., Esteves, J. P., & Noya-Rabelo, M. M. (2012). Hemoglobin Level Adds Prognostic Value to the Global Registry of Acute Coronary Events Score in Non-ST Elevation Acute Coronary Syndromes. Cardiology, 121(4), 213-9. https://doi.org/10.1159/000336954
Correia LC, et al. Hemoglobin Level Adds Prognostic Value to the Global Registry of Acute Coronary Events Score in Non-ST Elevation Acute Coronary Syndromes. Cardiology. 2012;121(4):213-9. PubMed PMID: 22516872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hemoglobin Level Adds Prognostic Value to the Global Registry of Acute Coronary Events Score in Non-ST Elevation Acute Coronary Syndromes. AU - Correia,Luis C L, AU - Souza,Alexandre C, AU - Sabino,Michael, AU - Brito,Mariana, AU - Maraux,Mayara, AU - Garcia,Guilherme, AU - Esteves,J Péricles, AU - Noya-Rabelo,Márcia M, Y1 - 2012/04/19/ PY - 2011/11/17/received PY - 2011/12/30/accepted PY - 2012/4/21/entrez PY - 2012/4/21/pubmed PY - 2015/7/24/medline SP - 213 EP - 9 JF - Cardiology JO - Cardiology VL - 121 IS - 4 N2 - OBJECTIVE: We aimed to test the hypothesis that hemoglobin values add prognostic information to the Global Registry of Acute Coronary Events (GRACE) score at admission in patients with non-ST elevation acute coronary syndromes (ACS). METHODS: A total of 225 consecutive patients with non-ST elevation ACS were studied. Hemoglobin was measured at admission, and its prognostic value was evaluated in relation to cardiovascular events during hospitalization, defined as the composite of death or myocardial infarction. RESULTS: The incidence of major in-hospital events was 7% (10 deaths and 5 nonfatal myocardial infarctions). Hemoglobin significantly predicted events, with a C statistic of 0.67 [95% confidence interval (CI) 0.53-0.81; p = 0.03], with 12.1 g/dl as the cutoff point of best performance. After adjustment for the GRACE score, low hemoglobin (≤12.1 g/dl) remained an independent predictor of events (odds ratio 3.9, 95% CI 1.2-13; p = 0.028). The C statistic of the GRACE score for prediction of events improved from 0.80 to 0.84 after hemoglobin was taken into account. Finally, the addition of hemoglobin to the GRACE score promoted a net reclassification improvement of 16% in identifying high-risk patients (p = 0.025). CONCLUSIONS: The present study provides preliminary evidence that hemoglobin level independently predicts recurrent events during hospitalization and improves the prognostic performance of the GRACE score in patients with non-ST elevation ACS. SN - 1421-9751 UR - https://www.unboundmedicine.com/medline/citation/22516872/Hemoglobin_Level_Adds_Prognostic_Value_to_the_Global_Registry_of_Acute_Coronary_Events_Score_in_Non_ST_Elevation_Acute_Coronary_Syndromes_ L2 - https://www.karger.com?DOI=10.1159/000336954 DB - PRIME DP - Unbound Medicine ER -