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Rotating night shift work and polymorphism of genes important for the regulation of circadian rhythm.
Scand J Work Environ Health. 2013 Mar 01; 39(2):178-86.SJ

Abstract

OBJECTIVE

People living in industrialized societies have developed specific working schedules during the day and at night, including permanent night shifts and rotating night shifts. The aim of this study was to examine the association between circadian polymorphisms and rotating night shift work.

METHODS

This cross-sectional study comprised 709 nurses and midwives (348 current rotating and 361 current day workers). Genetic polymorphism of selected clock genes BMAL1 (rs2279287), CLOCK (rs1801260), PER1 (rs2735611), PER2 (rs2304672), PER3 (rs10462020), CRY1 (rs8192440), CRY2 (rs10838527, rs10838527) was determined using real-time polymerase chain reaction (PCR) assays.

RESULTS

There were no differences in BMAL1, CLOCK, CRY2, PER1, PER2, and PER3 genotypes among nurses and midwives working rotating night and day shifts. The frequency of women with rare CRY1 TT genotype was higher in the group of rotating night shift than day workers (17.0% versus 13.9%, P=0.06). Moreover, CRY1 TT genotype was associated with the total rotating shift-work duration, compared to women rarely working night shifts.

CONCLUSIONS

These results suggest that CRY1 (rs8192440) polymorphism may influence the adaptation to the rotating night shift work among nurses and midwives.

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Authors+Show Affiliations

Reszka E
Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, 8 Teresy Street, Lodz, Poland. edyta@imp.lodz.pl
Peplonska B
No affiliation info available
Wieczorek E
No affiliation info available
Sobala W
No affiliation info available
Bukowska A
No affiliation info available
Gromadzinska J
No affiliation info available
Lie JA
No affiliation info available
Kjuus H
No affiliation info available
Wasowicz W
No affiliation info available

MeSH

Adaptation, PhysiologicalAdultCircadian RhythmCircadian Rhythm Signaling Peptides and ProteinsCross-Sectional StudiesFemaleHumansMiddle AgedNursesPolymorphism, GeneticWork Schedule Tolerance

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22517501

Citation

Reszka, Edyta, et al. "Rotating Night Shift Work and Polymorphism of Genes Important for the Regulation of Circadian Rhythm." Scandinavian Journal of Work, Environment & Health, vol. 39, no. 2, 2013, pp. 178-86.
Reszka E, Peplonska B, Wieczorek E, et al. Rotating night shift work and polymorphism of genes important for the regulation of circadian rhythm. Scand J Work Environ Health. 2013;39(2):178-86.
Reszka, E., Peplonska, B., Wieczorek, E., Sobala, W., Bukowska, A., Gromadzinska, J., Lie, J. A., Kjuus, H., & Wasowicz, W. (2013). Rotating night shift work and polymorphism of genes important for the regulation of circadian rhythm. Scandinavian Journal of Work, Environment & Health, 39(2), 178-86. https://doi.org/10.5271/sjweh.3299
Reszka E, et al. Rotating Night Shift Work and Polymorphism of Genes Important for the Regulation of Circadian Rhythm. Scand J Work Environ Health. 2013 Mar 1;39(2):178-86. PubMed PMID: 22517501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rotating night shift work and polymorphism of genes important for the regulation of circadian rhythm. AU - Reszka,Edyta, AU - Peplonska,Beata, AU - Wieczorek,Edyta, AU - Sobala,Wojciech, AU - Bukowska,Agnieszka, AU - Gromadzinska,Jolanta, AU - Lie,Jenny-Anne, AU - Kjuus,Helge, AU - Wasowicz,Wojciech, Y1 - 2012/04/19/ PY - 2012/4/21/entrez PY - 2012/4/21/pubmed PY - 2013/9/10/medline SP - 178 EP - 86 JF - Scandinavian journal of work, environment & health JO - Scand J Work Environ Health VL - 39 IS - 2 N2 - OBJECTIVE: People living in industrialized societies have developed specific working schedules during the day and at night, including permanent night shifts and rotating night shifts. The aim of this study was to examine the association between circadian polymorphisms and rotating night shift work. METHODS: This cross-sectional study comprised 709 nurses and midwives (348 current rotating and 361 current day workers). Genetic polymorphism of selected clock genes BMAL1 (rs2279287), CLOCK (rs1801260), PER1 (rs2735611), PER2 (rs2304672), PER3 (rs10462020), CRY1 (rs8192440), CRY2 (rs10838527, rs10838527) was determined using real-time polymerase chain reaction (PCR) assays. RESULTS: There were no differences in BMAL1, CLOCK, CRY2, PER1, PER2, and PER3 genotypes among nurses and midwives working rotating night and day shifts. The frequency of women with rare CRY1 TT genotype was higher in the group of rotating night shift than day workers (17.0% versus 13.9%, P=0.06). Moreover, CRY1 TT genotype was associated with the total rotating shift-work duration, compared to women rarely working night shifts. CONCLUSIONS: These results suggest that CRY1 (rs8192440) polymorphism may influence the adaptation to the rotating night shift work among nurses and midwives. SN - 1795-990X UR - https://www.unboundmedicine.com/medline/citation/22517501/Rotating_night_shift_work_and_polymorphism_of_genes_important_for_the_regulation_of_circadian_rhythm_ L2 - https://www.sjweh.fi/show_abstract.php?abstract_id=3299 DB - PRIME DP - Unbound Medicine ER -