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Acetylcholinesterase inhibition, antioxidant, antiinflammatory, antimicrobial and phytochemical properties of Huernia hystrix.
Phytother Res. 2012 May; 26(5):639-45.PR

Abstract

Huernia species are typical famine-food plants consumed in southern Ethiopia. H. hystrix is a heavily exploited ethnomedicinal succulent plant traded in traditional medicine systems especially on South Africa's eastern seaboard. This study investigated the acetylcholinesterase (AChE) inhibition, antioxidant, antiinflammatory and antimicrobial properties of extracts obtained from the stems and roots of this plant. At the same concentration level (625.0, 312.5 or 156.3 µg/mL), the whole plant extract showed higher AChE inhibitory activity when compared with the stem and root extracts; a finding suggesting the presence of AChE inhibitors acting additively or synergistically in the whole plant extract. The roots showed strong antioxidant activity (in DPPH and β-carotene assays) comparable to that of butylated hydroxytoluene (BHT), indicating the presence of potent antioxidant compound(s) that can be exploited as alternatives for use in the food and cosmetic industries and/or as nutraceuticals. All the petroleum ether (PE) (except root PE) and dichloromethane (DCM) extracts demonstrated good inhibitory activity (> 70%) in cyclooxygenase (COX-1 and COX-2) assays at a 0.25 µg/μL concentration. Most of the extracts showed broad-spectrum inhibitory and lethal activities against the microorganisms used in this study. The observed biological activities might be due to the iridoid, phenolic and flavonoid contents of the plants.

Authors+Show Affiliations

Research Centre for Plant Growth and Development, School of Biological and Conservation Sciences, University of KwaZulu-Natal Pietermaritzburg, Private Bag X01, Scottsville, 3209, South Africa.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22517510

Citation

Amoo, Stephen O., et al. "Acetylcholinesterase Inhibition, Antioxidant, Antiinflammatory, Antimicrobial and Phytochemical Properties of Huernia Hystrix." Phytotherapy Research : PTR, vol. 26, no. 5, 2012, pp. 639-45.
Amoo SO, Finnie JF, Van Staden J. Acetylcholinesterase inhibition, antioxidant, antiinflammatory, antimicrobial and phytochemical properties of Huernia hystrix. Phytother Res. 2012;26(5):639-45.
Amoo, S. O., Finnie, J. F., & Van Staden, J. (2012). Acetylcholinesterase inhibition, antioxidant, antiinflammatory, antimicrobial and phytochemical properties of Huernia hystrix. Phytotherapy Research : PTR, 26(5), 639-45. https://doi.org/10.1002/ptr.3614
Amoo SO, Finnie JF, Van Staden J. Acetylcholinesterase Inhibition, Antioxidant, Antiinflammatory, Antimicrobial and Phytochemical Properties of Huernia Hystrix. Phytother Res. 2012;26(5):639-45. PubMed PMID: 22517510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acetylcholinesterase inhibition, antioxidant, antiinflammatory, antimicrobial and phytochemical properties of Huernia hystrix. AU - Amoo,Stephen O, AU - Finnie,Jeffrey F, AU - Van Staden,Johannes, Y1 - 2011/10/05/ PY - 2011/02/19/received PY - 2011/05/10/revised PY - 2011/06/22/accepted PY - 2012/4/21/entrez PY - 2012/4/21/pubmed PY - 2013/10/18/medline SP - 639 EP - 45 JF - Phytotherapy research : PTR JO - Phytother Res VL - 26 IS - 5 N2 - Huernia species are typical famine-food plants consumed in southern Ethiopia. H. hystrix is a heavily exploited ethnomedicinal succulent plant traded in traditional medicine systems especially on South Africa's eastern seaboard. This study investigated the acetylcholinesterase (AChE) inhibition, antioxidant, antiinflammatory and antimicrobial properties of extracts obtained from the stems and roots of this plant. At the same concentration level (625.0, 312.5 or 156.3 µg/mL), the whole plant extract showed higher AChE inhibitory activity when compared with the stem and root extracts; a finding suggesting the presence of AChE inhibitors acting additively or synergistically in the whole plant extract. The roots showed strong antioxidant activity (in DPPH and β-carotene assays) comparable to that of butylated hydroxytoluene (BHT), indicating the presence of potent antioxidant compound(s) that can be exploited as alternatives for use in the food and cosmetic industries and/or as nutraceuticals. All the petroleum ether (PE) (except root PE) and dichloromethane (DCM) extracts demonstrated good inhibitory activity (> 70%) in cyclooxygenase (COX-1 and COX-2) assays at a 0.25 µg/μL concentration. Most of the extracts showed broad-spectrum inhibitory and lethal activities against the microorganisms used in this study. The observed biological activities might be due to the iridoid, phenolic and flavonoid contents of the plants. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/22517510/Acetylcholinesterase_inhibition_antioxidant_antiinflammatory_antimicrobial_and_phytochemical_properties_of_Huernia_hystrix_ L2 - https://doi.org/10.1002/ptr.3614 DB - PRIME DP - Unbound Medicine ER -