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Chronic Al2O3-nanoparticle exposure causes neurotoxic effects on locomotion behaviors by inducing severe ROS production and disruption of ROS defense mechanisms in nematode Caenorhabditis elegans.
J Hazard Mater. 2012 Jun 15; 219-220:221-30.JH

Abstract

To date, knowledge on mechanisms regarding the chronic nanotoxicity is still largely minimal. In the present study, the effect of chronic (10-day) Al(2)O(3)-nanoparticles (NPs) toxicity on locomotion behavior was investigated in the nematode Caenorhabditis elegans. Exposure to 0.01-23.1 mg/L of Al(2)O(3)-NPs induced a decrease in locomotion behavior, a severe stress response, and a severe oxidative stress; however, these effects were only detected in nematodes exposed to 23.1 mg/L of bulk Al(2)O(3). Formation of significant oxidative stress in nematodes exposed to Al(2)O(3)-NPs was due to both the increase in ROS production and the suppression of ROS defense mechanisms. More pronounced increases in ROS, decreases in SOD activity, and decrease in expression of genes encoding Mn-SODs (sod-2 and sod-3) were detected in nematodes exposed to Al(2)O(3)-NPs compared with bulk Al(2)O(3). Moreover, treatment with antioxidants or SOD-3 overexpression not only suppressed oxidative stress but also prevented adverse effects on locomotion behaviors from Al(2)O(3)-NPs exposure. Thus, chronic exposure to Al(2)O(3)-NPs may have adverse effects on locomotion behaviors by both induction of ROS production and disruption of ROS defense mechanisms. Furthermore, sod-2 and sod-3 mutants were more susceptible than the wild-type to chronic Al(2)O(3)-NPs-induced neurotoxicity inhibition.

Authors+Show Affiliations

Key Laboratory of Environmental Medicine Engineering in Ministry of Education, Department of Biochemistry and Molecular Biology, Medical School of Southeast University, Nanjing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22521136

Citation

Li, Yinxia, et al. "Chronic Al2O3-nanoparticle Exposure Causes Neurotoxic Effects On Locomotion Behaviors By Inducing Severe ROS Production and Disruption of ROS Defense Mechanisms in Nematode Caenorhabditis Elegans." Journal of Hazardous Materials, vol. 219-220, 2012, pp. 221-30.
Li Y, Yu S, Wu Q, et al. Chronic Al2O3-nanoparticle exposure causes neurotoxic effects on locomotion behaviors by inducing severe ROS production and disruption of ROS defense mechanisms in nematode Caenorhabditis elegans. J Hazard Mater. 2012;219-220:221-30.
Li, Y., Yu, S., Wu, Q., Tang, M., Pu, Y., & Wang, D. (2012). Chronic Al2O3-nanoparticle exposure causes neurotoxic effects on locomotion behaviors by inducing severe ROS production and disruption of ROS defense mechanisms in nematode Caenorhabditis elegans. Journal of Hazardous Materials, 219-220, 221-30. https://doi.org/10.1016/j.jhazmat.2012.03.083
Li Y, et al. Chronic Al2O3-nanoparticle Exposure Causes Neurotoxic Effects On Locomotion Behaviors By Inducing Severe ROS Production and Disruption of ROS Defense Mechanisms in Nematode Caenorhabditis Elegans. J Hazard Mater. 2012 Jun 15;219-220:221-30. PubMed PMID: 22521136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic Al2O3-nanoparticle exposure causes neurotoxic effects on locomotion behaviors by inducing severe ROS production and disruption of ROS defense mechanisms in nematode Caenorhabditis elegans. AU - Li,Yinxia, AU - Yu,Shunhui, AU - Wu,Quili, AU - Tang,Meng, AU - Pu,Yuepu, AU - Wang,Dayong, Y1 - 2012/04/06/ PY - 2011/10/06/received PY - 2012/03/30/revised PY - 2012/03/31/accepted PY - 2012/4/24/entrez PY - 2012/4/24/pubmed PY - 2012/8/3/medline SP - 221 EP - 30 JF - Journal of hazardous materials JO - J Hazard Mater VL - 219-220 N2 - To date, knowledge on mechanisms regarding the chronic nanotoxicity is still largely minimal. In the present study, the effect of chronic (10-day) Al(2)O(3)-nanoparticles (NPs) toxicity on locomotion behavior was investigated in the nematode Caenorhabditis elegans. Exposure to 0.01-23.1 mg/L of Al(2)O(3)-NPs induced a decrease in locomotion behavior, a severe stress response, and a severe oxidative stress; however, these effects were only detected in nematodes exposed to 23.1 mg/L of bulk Al(2)O(3). Formation of significant oxidative stress in nematodes exposed to Al(2)O(3)-NPs was due to both the increase in ROS production and the suppression of ROS defense mechanisms. More pronounced increases in ROS, decreases in SOD activity, and decrease in expression of genes encoding Mn-SODs (sod-2 and sod-3) were detected in nematodes exposed to Al(2)O(3)-NPs compared with bulk Al(2)O(3). Moreover, treatment with antioxidants or SOD-3 overexpression not only suppressed oxidative stress but also prevented adverse effects on locomotion behaviors from Al(2)O(3)-NPs exposure. Thus, chronic exposure to Al(2)O(3)-NPs may have adverse effects on locomotion behaviors by both induction of ROS production and disruption of ROS defense mechanisms. Furthermore, sod-2 and sod-3 mutants were more susceptible than the wild-type to chronic Al(2)O(3)-NPs-induced neurotoxicity inhibition. SN - 1873-3336 UR - https://www.unboundmedicine.com/medline/citation/22521136/Chronic_Al2O3_nanoparticle_exposure_causes_neurotoxic_effects_on_locomotion_behaviors_by_inducing_severe_ROS_production_and_disruption_of_ROS_defense_mechanisms_in_nematode_Caenorhabditis_elegans_ DB - PRIME DP - Unbound Medicine ER -