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Cost-effectiveness of 13-valent pneumococcal conjugate vaccine in Switzerland.
Vaccine. 2012 Jun 13; 30(28):4267-75.V

Abstract

The 7-valent pneumococcal conjugate vaccine (PCV7) has been shown to be highly cost-effective. The 13-valent pneumococcal conjugate vaccine (PCV13) offers seroprotection against six additional serotypes. A decision-analytic model was constructed to estimate direct medical costs and clinical effectiveness of PCV13 vaccination on invasive pneumococcal disease (IPD), pneumonia, and otitis media relative to PCV7 vaccination. The option with an one-dose catch-up vaccination in children of 15-59 months was also considered. Assuming 83% vaccination coverage and considering indirect effects, 1808 IPD, 5558 pneumonia and 74,136 otitis media cases could be eliminated from the entire population during a 10-year modelling period. The PCV13 vaccination programme would lead to additional costs (+€26.2 Mio), but saved medical costs of -€77.1 Mio due to cases averted and deaths avoided, overcompensate these costs (total cost savings -€50.9 Mio). The national immunisation programmes with PCV13 can be assumed cost saving when compared with the current vaccine PCV7 in Switzerland.

Authors+Show Affiliations

Institute of Social and Preventive Medicine, Medical Economics, University of Zurich, Switzerland. patricia.blank@ifspm.uzh.chNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22521287

Citation

Blank, Patricia R., and Thomas D. Szucs. "Cost-effectiveness of 13-valent Pneumococcal Conjugate Vaccine in Switzerland." Vaccine, vol. 30, no. 28, 2012, pp. 4267-75.
Blank PR, Szucs TD. Cost-effectiveness of 13-valent pneumococcal conjugate vaccine in Switzerland. Vaccine. 2012;30(28):4267-75.
Blank, P. R., & Szucs, T. D. (2012). Cost-effectiveness of 13-valent pneumococcal conjugate vaccine in Switzerland. Vaccine, 30(28), 4267-75. https://doi.org/10.1016/j.vaccine.2012.04.028
Blank PR, Szucs TD. Cost-effectiveness of 13-valent Pneumococcal Conjugate Vaccine in Switzerland. Vaccine. 2012 Jun 13;30(28):4267-75. PubMed PMID: 22521287.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cost-effectiveness of 13-valent pneumococcal conjugate vaccine in Switzerland. AU - Blank,Patricia R, AU - Szucs,Thomas D, Y1 - 2012/04/20/ PY - 2011/09/22/received PY - 2012/03/15/revised PY - 2012/04/03/accepted PY - 2012/4/24/entrez PY - 2012/4/24/pubmed PY - 2012/9/21/medline SP - 4267 EP - 75 JF - Vaccine JO - Vaccine VL - 30 IS - 28 N2 - The 7-valent pneumococcal conjugate vaccine (PCV7) has been shown to be highly cost-effective. The 13-valent pneumococcal conjugate vaccine (PCV13) offers seroprotection against six additional serotypes. A decision-analytic model was constructed to estimate direct medical costs and clinical effectiveness of PCV13 vaccination on invasive pneumococcal disease (IPD), pneumonia, and otitis media relative to PCV7 vaccination. The option with an one-dose catch-up vaccination in children of 15-59 months was also considered. Assuming 83% vaccination coverage and considering indirect effects, 1808 IPD, 5558 pneumonia and 74,136 otitis media cases could be eliminated from the entire population during a 10-year modelling period. The PCV13 vaccination programme would lead to additional costs (+€26.2 Mio), but saved medical costs of -€77.1 Mio due to cases averted and deaths avoided, overcompensate these costs (total cost savings -€50.9 Mio). The national immunisation programmes with PCV13 can be assumed cost saving when compared with the current vaccine PCV7 in Switzerland. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/22521287/Cost_effectiveness_of_13_valent_pneumococcal_conjugate_vaccine_in_Switzerland_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(12)00550-6 DB - PRIME DP - Unbound Medicine ER -