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New insights on endocannabinoid transmission in psychomotor disorders.

Abstract

The endocannabinoids are lipid signaling molecules that bind to cannabinoid CB(1) and CB(2) receptors and other metabotropic and ionotropic receptors. Anandamide and 2-arachidonoyl glycerol, the two best-characterized examples, are released on demand in a stimulus-dependent manner by cleavage of membrane phospholipid precursors. Together with their receptors and metabolic enzymes, the endocannabinoids play a key role in modulating neurotransmission and synaptic plasticity in the basal ganglia and other brain areas involved in the control of motor functions and motivational aspects of behavior. This mini-review provides an update on the contribution of the endocannabinoid system to the regulation of psychomotor behaviors and its possible involvement in the pathophysiology of Parkinson's disease and schizophrenia.

Authors+Show Affiliations

Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA. giuffrida@uthscsa.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

22521335

Citation

Giuffrida, Andrea, and Alexandre Seillier. "New Insights On Endocannabinoid Transmission in Psychomotor Disorders." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 38, no. 1, 2012, pp. 51-8.
Giuffrida A, Seillier A. New insights on endocannabinoid transmission in psychomotor disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2012;38(1):51-8.
Giuffrida, A., & Seillier, A. (2012). New insights on endocannabinoid transmission in psychomotor disorders. Progress in Neuro-psychopharmacology & Biological Psychiatry, 38(1), pp. 51-8. doi:10.1016/j.pnpbp.2012.04.002.
Giuffrida A, Seillier A. New Insights On Endocannabinoid Transmission in Psychomotor Disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Jul 2;38(1):51-8. PubMed PMID: 22521335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New insights on endocannabinoid transmission in psychomotor disorders. AU - Giuffrida,Andrea, AU - Seillier,Alexandre, Y1 - 2012/04/10/ PY - 2012/01/19/received PY - 2012/03/26/revised PY - 2012/04/01/accepted PY - 2012/4/24/entrez PY - 2012/4/24/pubmed PY - 2012/12/10/medline SP - 51 EP - 8 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 38 IS - 1 N2 - The endocannabinoids are lipid signaling molecules that bind to cannabinoid CB(1) and CB(2) receptors and other metabotropic and ionotropic receptors. Anandamide and 2-arachidonoyl glycerol, the two best-characterized examples, are released on demand in a stimulus-dependent manner by cleavage of membrane phospholipid precursors. Together with their receptors and metabolic enzymes, the endocannabinoids play a key role in modulating neurotransmission and synaptic plasticity in the basal ganglia and other brain areas involved in the control of motor functions and motivational aspects of behavior. This mini-review provides an update on the contribution of the endocannabinoid system to the regulation of psychomotor behaviors and its possible involvement in the pathophysiology of Parkinson's disease and schizophrenia. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/22521335/New_insights_on_endocannabinoid_transmission_in_psychomotor_disorders_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(12)00074-7 DB - PRIME DP - Unbound Medicine ER -