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Merkel cell carcinoma: identification of prognostic factors unique to tumors located in the head and neck based on analysis of SEER data.
Laryngoscope. 2012 Jun; 122(6):1283-90.L

Abstract

OBJECTIVES/HYPOTHESIS

Merkel cell carcinoma (MCC) is an aggressive cutaneous neoplasm that occurs most frequently in the head and neck region. Because of its rarity, prognostic factors are poorly characterized. Head and neck MCC (HN-MCC) may require separate consideration from MCC that occurs in other anatomic regions. Our objective was to determine the relevance of clinicopathologic parameters as prognostic factors in a large series of patients with HN-MCC and to compare these to a series of patients with non-head and neck MCC (NHN-MCC).

STUDY DESIGN

Retrospective analysis of large population database.

METHODS

Patients with MCC were identified using the Surveillance, Epidemiology, and End Results database and categorized according to tumor location either 1) within or 2) outside of the head and neck region. Clinicopathologic data were compared between groups. Retrospective univariable and multivariable analyses of factors associated with disease-specific survival (DSS) were performed.

RESULTS

We identified 2,104 patients with HN-MCC and 2,272 with NHN-MCC. DSS was similar between groups. Independent prognostic factors in HN-MCC are male sex (P < .001), lip primary site (P = .005), tumor extension beyond the dermis (P = .03), histologically confirmed nodal disease (P < .001), absence of histologic lymph node evaluation (P = .01), and distant metastasis (P = .001). Male sex and tumor extension limited to the subcutis are prognostic factors that are unique to HN-MCC.

CONCLUSIONS

Because independent markers of aggressive disease appear to be unique in HN-MCC, it is important that future studies provide separate consideration for HN-MCC to allow for the most accurate identification of prognostic indicators and assessment of treatment outcomes accordingly.

Authors+Show Affiliations

College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22522673

Citation

Smith, Valerie A., et al. "Merkel Cell Carcinoma: Identification of Prognostic Factors Unique to Tumors Located in the Head and Neck Based On Analysis of SEER Data." The Laryngoscope, vol. 122, no. 6, 2012, pp. 1283-90.
Smith VA, Camp ER, Lentsch EJ. Merkel cell carcinoma: identification of prognostic factors unique to tumors located in the head and neck based on analysis of SEER data. Laryngoscope. 2012;122(6):1283-90.
Smith, V. A., Camp, E. R., & Lentsch, E. J. (2012). Merkel cell carcinoma: identification of prognostic factors unique to tumors located in the head and neck based on analysis of SEER data. The Laryngoscope, 122(6), 1283-90. https://doi.org/10.1002/lary.23222
Smith VA, Camp ER, Lentsch EJ. Merkel Cell Carcinoma: Identification of Prognostic Factors Unique to Tumors Located in the Head and Neck Based On Analysis of SEER Data. Laryngoscope. 2012;122(6):1283-90. PubMed PMID: 22522673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Merkel cell carcinoma: identification of prognostic factors unique to tumors located in the head and neck based on analysis of SEER data. AU - Smith,Valerie A, AU - Camp,E Ramsay, AU - Lentsch,Eric J, Y1 - 2012/04/20/ PY - 2011/10/25/received PY - 2011/12/12/revised PY - 2012/01/03/accepted PY - 2012/4/24/entrez PY - 2012/4/24/pubmed PY - 2012/8/18/medline SP - 1283 EP - 90 JF - The Laryngoscope JO - Laryngoscope VL - 122 IS - 6 N2 - OBJECTIVES/HYPOTHESIS: Merkel cell carcinoma (MCC) is an aggressive cutaneous neoplasm that occurs most frequently in the head and neck region. Because of its rarity, prognostic factors are poorly characterized. Head and neck MCC (HN-MCC) may require separate consideration from MCC that occurs in other anatomic regions. Our objective was to determine the relevance of clinicopathologic parameters as prognostic factors in a large series of patients with HN-MCC and to compare these to a series of patients with non-head and neck MCC (NHN-MCC). STUDY DESIGN: Retrospective analysis of large population database. METHODS: Patients with MCC were identified using the Surveillance, Epidemiology, and End Results database and categorized according to tumor location either 1) within or 2) outside of the head and neck region. Clinicopathologic data were compared between groups. Retrospective univariable and multivariable analyses of factors associated with disease-specific survival (DSS) were performed. RESULTS: We identified 2,104 patients with HN-MCC and 2,272 with NHN-MCC. DSS was similar between groups. Independent prognostic factors in HN-MCC are male sex (P < .001), lip primary site (P = .005), tumor extension beyond the dermis (P = .03), histologically confirmed nodal disease (P < .001), absence of histologic lymph node evaluation (P = .01), and distant metastasis (P = .001). Male sex and tumor extension limited to the subcutis are prognostic factors that are unique to HN-MCC. CONCLUSIONS: Because independent markers of aggressive disease appear to be unique in HN-MCC, it is important that future studies provide separate consideration for HN-MCC to allow for the most accurate identification of prognostic indicators and assessment of treatment outcomes accordingly. SN - 1531-4995 UR - https://www.unboundmedicine.com/medline/citation/22522673/Merkel_cell_carcinoma:_identification_of_prognostic_factors_unique_to_tumors_located_in_the_head_and_neck_based_on_analysis_of_SEER_data_ L2 - https://doi.org/10.1002/lary.23222 DB - PRIME DP - Unbound Medicine ER -