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Formulation and Evaluation of Cephalexin Extended-release Matrix Tablets Using Hydroxy Propyl Methyl Cellulose as Rate-controlling Polymer.
J Young Pharm. 2012 Jan; 4(1):3-12.JY

Abstract

The present investigation reports the design and evaluation of six-hour extended release film-coated matrix tablets of cephalexin using different grades of hydrophilic polymer hydroxypropylmethylcellulose (HPMC) employing direct compression method. The preformulation studies performed included the physical compatibility studies, Differential Scanning Calorimetry analysis, drug characterization using Fourier Transform Infra Red spectroscopic analysis and particle size analysis using sieve method. The tablets were evaluated for weight variation, hardness, thickness and friability. Results of the studies indicate that the polymers used have significant release-retarding effect on the formulation. The dissolution profile comparison of the prepared batches P1 to P8 and market preparation (Sporidex AF 375) was done by using Food and Drug Administration-recommended similarity factor (f(2)) determination. The formulation P8 (10% HPMC K4M, 15% HPMC 15cps) with a similarity factor (f(2)) of 77.75 was selected as the optimized formulae for scale-up batches. The dissolution data of the best formulation P8 was fitted into zero order, first order, Higuchi and Korsemeyer-Peppas models to identify the pharmacokinetics and mechanism of drug release. The results of the accelerated stability study of best formulation P8 for three months revealed that storage conditions were not found to have made any significant changes in final formulation F3. The release of cephalexin was prolonged for 6 h by using polymer combinations of HPMC and a twice daily matrix tablet was formulated.

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Authors+Show Affiliations

Vijay J
Department of Pharmaceutics, School of Pharmacy, Suresh Gyan Vihar University, Jaipur, India.
Sahadevan J
No affiliation info available
Prabhakaran R
No affiliation info available
Gilhotra RM
No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22523453

Citation

Vijay, J, et al. "Formulation and Evaluation of Cephalexin Extended-release Matrix Tablets Using Hydroxy Propyl Methyl Cellulose as Rate-controlling Polymer." Journal of Young Pharmacists : JYP, vol. 4, no. 1, 2012, pp. 3-12.
Vijay J, Sahadevan J, Prabhakaran R, et al. Formulation and Evaluation of Cephalexin Extended-release Matrix Tablets Using Hydroxy Propyl Methyl Cellulose as Rate-controlling Polymer. J Young Pharm. 2012;4(1):3-12.
Vijay, J., Sahadevan, J., Prabhakaran, R., & Gilhotra, R. M. (2012). Formulation and Evaluation of Cephalexin Extended-release Matrix Tablets Using Hydroxy Propyl Methyl Cellulose as Rate-controlling Polymer. Journal of Young Pharmacists : JYP, 4(1), 3-12. https://doi.org/10.4103/0975-1483.93570
Vijay J, et al. Formulation and Evaluation of Cephalexin Extended-release Matrix Tablets Using Hydroxy Propyl Methyl Cellulose as Rate-controlling Polymer. J Young Pharm. 2012;4(1):3-12. PubMed PMID: 22523453.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation and Evaluation of Cephalexin Extended-release Matrix Tablets Using Hydroxy Propyl Methyl Cellulose as Rate-controlling Polymer. AU - Vijay,J, AU - Sahadevan,Jt, AU - Prabhakaran,R, AU - Gilhotra,R Mehra, PY - 2012/4/24/entrez PY - 2012/4/24/pubmed PY - 2012/4/24/medline KW - Cephalexin KW - Fourier transform infra red spectroscopic KW - differential scanning calorimetry KW - hydroxy propyl methyl cellulose KW - matrix tablets KW - release kinetics KW - similarity factor (f2) SP - 3 EP - 12 JF - Journal of young pharmacists : JYP JO - J Young Pharm VL - 4 IS - 1 N2 - The present investigation reports the design and evaluation of six-hour extended release film-coated matrix tablets of cephalexin using different grades of hydrophilic polymer hydroxypropylmethylcellulose (HPMC) employing direct compression method. The preformulation studies performed included the physical compatibility studies, Differential Scanning Calorimetry analysis, drug characterization using Fourier Transform Infra Red spectroscopic analysis and particle size analysis using sieve method. The tablets were evaluated for weight variation, hardness, thickness and friability. Results of the studies indicate that the polymers used have significant release-retarding effect on the formulation. The dissolution profile comparison of the prepared batches P1 to P8 and market preparation (Sporidex AF 375) was done by using Food and Drug Administration-recommended similarity factor (f(2)) determination. The formulation P8 (10% HPMC K4M, 15% HPMC 15cps) with a similarity factor (f(2)) of 77.75 was selected as the optimized formulae for scale-up batches. The dissolution data of the best formulation P8 was fitted into zero order, first order, Higuchi and Korsemeyer-Peppas models to identify the pharmacokinetics and mechanism of drug release. The results of the accelerated stability study of best formulation P8 for three months revealed that storage conditions were not found to have made any significant changes in final formulation F3. The release of cephalexin was prolonged for 6 h by using polymer combinations of HPMC and a twice daily matrix tablet was formulated. SN - 0975-1505 UR - https://www.unboundmedicine.com/medline/citation/22523453/Formulation_and_Evaluation_of_Cephalexin_Extended_release_Matrix_Tablets_Using_Hydroxy_Propyl_Methyl_Cellulose_as_Rate_controlling_Polymer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0975-1483(12)41002-0 DB - PRIME DP - Unbound Medicine ER -