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Detection of Phl p 1, Phl p 5, Phl p 7 and Phl p 12 specific IgE antibodies in the sera of children and adult patients allergic to Phleum pollen.
Allergol Int. 2012 Jun; 61(2):339-46.AI

Abstract

BACKGROUND

Grasses belong to major sources of inhaled allergens. The knowledge of particular molecules responsible for hypersensitivity is of crucial importance for better understanding of individual differences among single allergic subjects and allergic populations living in various world-areas.

METHODS

Specific-IgE-antibodies against Phl p 1, Phl p 5, Phl p 7, Phl p 12 were detected in a group of 130 Phleum-allergic-subjects (82 children, 48 adults).

RESULTS

Phl p 1 antibodies were detected in most pediatric and adult patients, however, the children were associated with higher RAST classes more often. Anti-Phl p 5-antibodies were found more frequently in adults. An increase was observed in the number of pediatric patients reacting to Phl p 7 and Phl p 12. There were no differences in concentrations of specific-IgE against Phl p 5, Phl p 7 and Phl p 12 depending on age. Almost 10% of allergic children produced antibodies directed exclusively against minor allergens or did not produce specific-IgE-antibodies against tested molecules. Part of the patients reacted to profilin and calcium-binding protein originating from only one source (Phl p 12/Bet v 2 and Phl p 7/Bet v 4).

CONCLUSIONS

Antibodies against Phl p 1 and Phl p 5 can be used as a marker of allergy to grasses in adult patients. Children reacted exclusively to minor allergens more frequently than adults. Prolonged allergen exposure is evidently necessary to induce sensitization to Phl p 5. A high level of homology between profilins and calcium-binding proteins enables only one allergen to be used for diagnostic purposes but a possibility of a reaction to species-bound epitopes should be taken into account.

Authors+Show Affiliations

Department of Clinical and Transplant Immunology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. sekerkova@post.czNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22526205

Citation

Sekerkova, Alena, et al. "Detection of Phl P 1, Phl P 5, Phl P 7 and Phl P 12 Specific IgE Antibodies in the Sera of Children and Adult Patients Allergic to Phleum Pollen." Allergology International : Official Journal of the Japanese Society of Allergology, vol. 61, no. 2, 2012, pp. 339-46.
Sekerkova A, Polackova M, Striz I. Detection of Phl p 1, Phl p 5, Phl p 7 and Phl p 12 specific IgE antibodies in the sera of children and adult patients allergic to Phleum pollen. Allergol Int. 2012;61(2):339-46.
Sekerkova, A., Polackova, M., & Striz, I. (2012). Detection of Phl p 1, Phl p 5, Phl p 7 and Phl p 12 specific IgE antibodies in the sera of children and adult patients allergic to Phleum pollen. Allergology International : Official Journal of the Japanese Society of Allergology, 61(2), 339-46. https://doi.org/10.2332/allergolint.11-OA-0372
Sekerkova A, Polackova M, Striz I. Detection of Phl P 1, Phl P 5, Phl P 7 and Phl P 12 Specific IgE Antibodies in the Sera of Children and Adult Patients Allergic to Phleum Pollen. Allergol Int. 2012;61(2):339-46. PubMed PMID: 22526205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of Phl p 1, Phl p 5, Phl p 7 and Phl p 12 specific IgE antibodies in the sera of children and adult patients allergic to Phleum pollen. AU - Sekerkova,Alena, AU - Polackova,Marta, AU - Striz,Ilja, Y1 - 2012/04/25/ PY - 2011/09/18/received PY - 2011/12/27/accepted PY - 2012/4/25/entrez PY - 2012/4/25/pubmed PY - 2012/9/22/medline SP - 339 EP - 46 JF - Allergology international : official journal of the Japanese Society of Allergology JO - Allergol Int VL - 61 IS - 2 N2 - BACKGROUND: Grasses belong to major sources of inhaled allergens. The knowledge of particular molecules responsible for hypersensitivity is of crucial importance for better understanding of individual differences among single allergic subjects and allergic populations living in various world-areas. METHODS: Specific-IgE-antibodies against Phl p 1, Phl p 5, Phl p 7, Phl p 12 were detected in a group of 130 Phleum-allergic-subjects (82 children, 48 adults). RESULTS: Phl p 1 antibodies were detected in most pediatric and adult patients, however, the children were associated with higher RAST classes more often. Anti-Phl p 5-antibodies were found more frequently in adults. An increase was observed in the number of pediatric patients reacting to Phl p 7 and Phl p 12. There were no differences in concentrations of specific-IgE against Phl p 5, Phl p 7 and Phl p 12 depending on age. Almost 10% of allergic children produced antibodies directed exclusively against minor allergens or did not produce specific-IgE-antibodies against tested molecules. Part of the patients reacted to profilin and calcium-binding protein originating from only one source (Phl p 12/Bet v 2 and Phl p 7/Bet v 4). CONCLUSIONS: Antibodies against Phl p 1 and Phl p 5 can be used as a marker of allergy to grasses in adult patients. Children reacted exclusively to minor allergens more frequently than adults. Prolonged allergen exposure is evidently necessary to induce sensitization to Phl p 5. A high level of homology between profilins and calcium-binding proteins enables only one allergen to be used for diagnostic purposes but a possibility of a reaction to species-bound epitopes should be taken into account. SN - 1440-1592 UR - https://www.unboundmedicine.com/medline/citation/22526205/Detection_of_Phl_p_1_Phl_p_5_Phl_p_7_and_Phl_p_12_specific_IgE_antibodies_in_the_sera_of_children_and_adult_patients_allergic_to_Phleum_pollen_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1323-8930(15)30228-8 DB - PRIME DP - Unbound Medicine ER -