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Comorbidity profiles of chronic migraine sufferers in a national database in Taiwan.

Abstract

Chronic migraine (CM; ≥15 headache days per month, ≥3 months) is associated with a higher prevalence of comorbidities than episodic migraine (<15 headache days per month). However, it is unclear whether a similar pattern exists in Asian patients. To examine this, a retrospective matched cohort study was conducted using the Taiwan National Health Insurance Research Database. CM cases were defined as patients with at least one neurological outpatient visit with a primary or secondary ICD-9-CM (International Classification of Diseases, Ninth Revision, Clinical Modification) code of 346.11, diagnosed by neurologists at medical centers during 2007-2008. The study group was compared with patients suffering from other migraine subtypes and non-migraineurs in the general population. Both comparison groups were matched with CM sufferers at a 4:1 ratio by age, gender, urbanization level of the residence, income, and hospital setting. Relative risk (RR) was calculated using conditional logistic regression. Compared with patients with other migraines (n = 2,226), CM sufferers (n = 681) had a higher risk of hyperlipidemia (RR = 1.32; P = 0.041), asthma (RR = 1.77; P = 0.007), depression (RR = 1.88; P < 0.0001), bipolar disorder (RR = 1.81; P = 0.022) and anxiety disorders (RR = 1.48; P = <0.0001). Compared with the non-migraineurs (n = 3,790), CM sufferers (n = 948) had significantly increased risks of cardiovascular disease, sinusitis, asthma, gastrointestinal ulcers, vertigo and psychiatric disorders by 1.6-3.9-fold. In conclusion, CM is associated with significant comorbidities in Asian patients. Differences in the comorbidity profiles of CM compared with other migraines have highlighted that patients with CM differ not just in terms of headache frequency but also in other important aspects.

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  • Authors+Show Affiliations

    ,

    National Defense Medical Center, Graduate Institute of Life Sciences, Taipei, Taiwan.

    , ,

    Source

    The journal of headache and pain 13:4 2012 Jun pg 311-9

    MeSH

    Adult
    Cohort Studies
    Community Health Planning
    Comorbidity
    Databases as Topic
    Female
    Humans
    Male
    Middle Aged
    Migraine Disorders
    Prevalence
    Retrospective Studies
    Taiwan
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22527034

    Citation

    Chen, Yong-Chen, et al. "Comorbidity Profiles of Chronic Migraine Sufferers in a National Database in Taiwan." The Journal of Headache and Pain, vol. 13, no. 4, 2012, pp. 311-9.
    Chen YC, Tang CH, Ng K, et al. Comorbidity profiles of chronic migraine sufferers in a national database in Taiwan. J Headache Pain. 2012;13(4):311-9.
    Chen, Y. C., Tang, C. H., Ng, K., & Wang, S. J. (2012). Comorbidity profiles of chronic migraine sufferers in a national database in Taiwan. The Journal of Headache and Pain, 13(4), pp. 311-9. doi:10.1007/s10194-012-0447-4.
    Chen YC, et al. Comorbidity Profiles of Chronic Migraine Sufferers in a National Database in Taiwan. J Headache Pain. 2012;13(4):311-9. PubMed PMID: 22527034.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Comorbidity profiles of chronic migraine sufferers in a national database in Taiwan. AU - Chen,Yong-Chen, AU - Tang,Chao-Hsiun, AU - Ng,Kwong, AU - Wang,Shuu-Jiun, Y1 - 2012/04/12/ PY - 2012/01/12/received PY - 2012/03/27/accepted PY - 2012/4/25/entrez PY - 2012/4/25/pubmed PY - 2012/9/27/medline SP - 311 EP - 9 JF - The journal of headache and pain JO - J Headache Pain VL - 13 IS - 4 N2 - Chronic migraine (CM; ≥15 headache days per month, ≥3 months) is associated with a higher prevalence of comorbidities than episodic migraine (<15 headache days per month). However, it is unclear whether a similar pattern exists in Asian patients. To examine this, a retrospective matched cohort study was conducted using the Taiwan National Health Insurance Research Database. CM cases were defined as patients with at least one neurological outpatient visit with a primary or secondary ICD-9-CM (International Classification of Diseases, Ninth Revision, Clinical Modification) code of 346.11, diagnosed by neurologists at medical centers during 2007-2008. The study group was compared with patients suffering from other migraine subtypes and non-migraineurs in the general population. Both comparison groups were matched with CM sufferers at a 4:1 ratio by age, gender, urbanization level of the residence, income, and hospital setting. Relative risk (RR) was calculated using conditional logistic regression. Compared with patients with other migraines (n = 2,226), CM sufferers (n = 681) had a higher risk of hyperlipidemia (RR = 1.32; P = 0.041), asthma (RR = 1.77; P = 0.007), depression (RR = 1.88; P < 0.0001), bipolar disorder (RR = 1.81; P = 0.022) and anxiety disorders (RR = 1.48; P = <0.0001). Compared with the non-migraineurs (n = 3,790), CM sufferers (n = 948) had significantly increased risks of cardiovascular disease, sinusitis, asthma, gastrointestinal ulcers, vertigo and psychiatric disorders by 1.6-3.9-fold. In conclusion, CM is associated with significant comorbidities in Asian patients. Differences in the comorbidity profiles of CM compared with other migraines have highlighted that patients with CM differ not just in terms of headache frequency but also in other important aspects. SN - 1129-2377 UR - https://www.unboundmedicine.com/medline/citation/22527034/full_citation L2 - https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1007/s10194-012-0447-4 DB - PRIME DP - Unbound Medicine ER -