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Dietary intake of lignans and risk of adenocarcinoma of the esophagus and gastroesophageal junction.
Cancer Causes Control. 2012 Jun; 23(6):837-44.CC

Abstract

PURPOSE

The strong male predominance in esophageal and gastroesophageal junctional adenocarcinoma remains unexplained. Sex hormonal influence has been suggested, but not proven. A protective role of dietary phytoestrogen lignans was hypothesized.

METHODS

A Swedish nationwide population-based case-control study was conducted in 1995-1997, including 181 cases of esophageal adenocarcinoma, 255 cases of gastroesophageal junctional adenocarcinoma, 158 cases of esophageal squamous cell carcinoma, and 806 control subjects. Data on various exposures, including dietary data, were collected through personal interviews and questionnaires. Dietary intake of lignans was assessed using a food frequency questionnaire and categorized into quartiles based on the consumption among the control participants. Unconditional logistic regression was used to calculate odds ratios (ORs) with 95 % confidence intervals (CIs), including adjustment for all established risk factors.

RESULTS

Participants in the highest quartile of intake of lignans compared with the lowest quartile were at a decreased risk of esophageal adenocarcinoma (OR, 0.65; 95 % CI, 0.38-1.12; p for trend =0.03), gastroesophageal junctional adenocarcinoma (OR, 0.37; 95 % CI, 0.23-0.58; p for trend <0.0001), and these adenocarcinomas combined (OR, 0.45; 95 % CI, 0.31-0.67; p for trend <0.0001). No clear associations were found between lignan intake and risk of esophageal squamous cell carcinoma.

CONCLUSIONS

This population-based study indicates that a high dietary intake of lignans decreases the risk of adenocarcinoma of the esophagus and gastroesophageal junction.

Authors+Show Affiliations

Unit of Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Norra Stationsgatan 67, Stockholm, Sweden. yulan.lin@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22527161

Citation

Lin, Yulan, et al. "Dietary Intake of Lignans and Risk of Adenocarcinoma of the Esophagus and Gastroesophageal Junction." Cancer Causes & Control : CCC, vol. 23, no. 6, 2012, pp. 837-44.
Lin Y, Yngve A, Lagergren J, et al. Dietary intake of lignans and risk of adenocarcinoma of the esophagus and gastroesophageal junction. Cancer Causes Control. 2012;23(6):837-44.
Lin, Y., Yngve, A., Lagergren, J., & Lu, Y. (2012). Dietary intake of lignans and risk of adenocarcinoma of the esophagus and gastroesophageal junction. Cancer Causes & Control : CCC, 23(6), 837-44. https://doi.org/10.1007/s10552-012-9952-7
Lin Y, et al. Dietary Intake of Lignans and Risk of Adenocarcinoma of the Esophagus and Gastroesophageal Junction. Cancer Causes Control. 2012;23(6):837-44. PubMed PMID: 22527161.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of lignans and risk of adenocarcinoma of the esophagus and gastroesophageal junction. AU - Lin,Yulan, AU - Yngve,Agneta, AU - Lagergren,Jesper, AU - Lu,Yunxia, Y1 - 2012/04/17/ PY - 2011/10/18/received PY - 2012/03/26/accepted PY - 2012/4/25/entrez PY - 2012/4/25/pubmed PY - 2012/11/9/medline SP - 837 EP - 44 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 23 IS - 6 N2 - PURPOSE: The strong male predominance in esophageal and gastroesophageal junctional adenocarcinoma remains unexplained. Sex hormonal influence has been suggested, but not proven. A protective role of dietary phytoestrogen lignans was hypothesized. METHODS: A Swedish nationwide population-based case-control study was conducted in 1995-1997, including 181 cases of esophageal adenocarcinoma, 255 cases of gastroesophageal junctional adenocarcinoma, 158 cases of esophageal squamous cell carcinoma, and 806 control subjects. Data on various exposures, including dietary data, were collected through personal interviews and questionnaires. Dietary intake of lignans was assessed using a food frequency questionnaire and categorized into quartiles based on the consumption among the control participants. Unconditional logistic regression was used to calculate odds ratios (ORs) with 95 % confidence intervals (CIs), including adjustment for all established risk factors. RESULTS: Participants in the highest quartile of intake of lignans compared with the lowest quartile were at a decreased risk of esophageal adenocarcinoma (OR, 0.65; 95 % CI, 0.38-1.12; p for trend =0.03), gastroesophageal junctional adenocarcinoma (OR, 0.37; 95 % CI, 0.23-0.58; p for trend <0.0001), and these adenocarcinomas combined (OR, 0.45; 95 % CI, 0.31-0.67; p for trend <0.0001). No clear associations were found between lignan intake and risk of esophageal squamous cell carcinoma. CONCLUSIONS: This population-based study indicates that a high dietary intake of lignans decreases the risk of adenocarcinoma of the esophagus and gastroesophageal junction. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/22527161/Dietary_intake_of_lignans_and_risk_of_adenocarcinoma_of_the_esophagus_and_gastroesophageal_junction_ L2 - https://doi.org/10.1007/s10552-012-9952-7 DB - PRIME DP - Unbound Medicine ER -