Tags

Type your tag names separated by a space and hit enter

A cross-sectional analysis of the association between diet and insulin-like growth factor (IGF)-I, IGF-II, IGF-binding protein (IGFBP)-2, and IGFBP-3 in men in the United Kingdom.
Cancer Causes Control 2012; 23(6):907-17CC

Abstract

BACKGROUND

There is evidence of associations between insulin-like growth factor I (IGF-I), IGF-II, insulin-like binding protein-2 (IGFBP-2), IGFBP-3, and prostate cancer risk. This study examines the association between dietary factors associated with prostate cancer and serum levels of these peptides.

METHODS

A cross-sectional analysis of self-reported 12-month dietary intake with serum IGF and IGFBP levels was performed using data from 1,798 subjects screened negative for prostate cancer as part of a UK multicenter trial comparing treatments for this condition. Multivariable linear regression models tested associations of diet with IGFs and IGFBPs.

RESULTS

For a one standard deviation (SD) increase in dairy product and dairy protein intake, IGF-I increased by 5.28 ng/mL (95 % confidence interval: 2.64, 7.92 ng/mL) and 6.02 ng/mL (3.34, 8.71 ng/mL), respectively. A 25 % increase in calcium and selenium intake was associated with an increase in IGF-I of 5.92 ng/mL (3.77, 8.07 ng/mL) and 2.61 ng/mL (1.10, 4.13 ng/mL), respectively. A one SD increase in animal protein was associated with a decrease in IGFBP-2 of 6.20 % (-8.91, -3.41 %), and there was some evidence of an inverse association with dairy protein and calcium. There was no evidence of any dietary associations with IGFBP-3 or IGF-II.

CONCLUSIONS

Diet is associated with IGF-I and IGFBP-2 levels in men in the UK, and these peptides warrant further investigation as part of randomized trials of dietary interventions to reduce the risk or progression of prostate cancer. There is no evidence that IGF-II or IGFBP-3 are mediators of dietary associations with prostate cancer.

Authors+Show Affiliations

School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, UK. nick.young@bristol.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22527168

Citation

Young, Nicholas J., et al. "A Cross-sectional Analysis of the Association Between Diet and Insulin-like Growth Factor (IGF)-I, IGF-II, IGF-binding Protein (IGFBP)-2, and IGFBP-3 in Men in the United Kingdom." Cancer Causes & Control : CCC, vol. 23, no. 6, 2012, pp. 907-17.
Young NJ, Metcalfe C, Gunnell D, et al. A cross-sectional analysis of the association between diet and insulin-like growth factor (IGF)-I, IGF-II, IGF-binding protein (IGFBP)-2, and IGFBP-3 in men in the United Kingdom. Cancer Causes Control. 2012;23(6):907-17.
Young, N. J., Metcalfe, C., Gunnell, D., Rowlands, M. A., Lane, J. A., Gilbert, R., ... Holly, J. M. (2012). A cross-sectional analysis of the association between diet and insulin-like growth factor (IGF)-I, IGF-II, IGF-binding protein (IGFBP)-2, and IGFBP-3 in men in the United Kingdom. Cancer Causes & Control : CCC, 23(6), pp. 907-17. doi:10.1007/s10552-012-9961-6.
Young NJ, et al. A Cross-sectional Analysis of the Association Between Diet and Insulin-like Growth Factor (IGF)-I, IGF-II, IGF-binding Protein (IGFBP)-2, and IGFBP-3 in Men in the United Kingdom. Cancer Causes Control. 2012;23(6):907-17. PubMed PMID: 22527168.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A cross-sectional analysis of the association between diet and insulin-like growth factor (IGF)-I, IGF-II, IGF-binding protein (IGFBP)-2, and IGFBP-3 in men in the United Kingdom. AU - Young,Nicholas J, AU - Metcalfe,Chris, AU - Gunnell,David, AU - Rowlands,Mari-Anne, AU - Lane,J Athene, AU - Gilbert,Rebecca, AU - Avery,Kerry N L, AU - Davis,Michael, AU - Neal,David E, AU - Hamdy,Freddie C, AU - Donovan,Jenny, AU - Martin,Richard M, AU - Holly,Jeff M P, Y1 - 2012/04/21/ PY - 2011/12/09/received PY - 2012/04/06/accepted PY - 2012/4/25/entrez PY - 2012/4/25/pubmed PY - 2012/11/9/medline SP - 907 EP - 17 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 23 IS - 6 N2 - BACKGROUND: There is evidence of associations between insulin-like growth factor I (IGF-I), IGF-II, insulin-like binding protein-2 (IGFBP-2), IGFBP-3, and prostate cancer risk. This study examines the association between dietary factors associated with prostate cancer and serum levels of these peptides. METHODS: A cross-sectional analysis of self-reported 12-month dietary intake with serum IGF and IGFBP levels was performed using data from 1,798 subjects screened negative for prostate cancer as part of a UK multicenter trial comparing treatments for this condition. Multivariable linear regression models tested associations of diet with IGFs and IGFBPs. RESULTS: For a one standard deviation (SD) increase in dairy product and dairy protein intake, IGF-I increased by 5.28 ng/mL (95 % confidence interval: 2.64, 7.92 ng/mL) and 6.02 ng/mL (3.34, 8.71 ng/mL), respectively. A 25 % increase in calcium and selenium intake was associated with an increase in IGF-I of 5.92 ng/mL (3.77, 8.07 ng/mL) and 2.61 ng/mL (1.10, 4.13 ng/mL), respectively. A one SD increase in animal protein was associated with a decrease in IGFBP-2 of 6.20 % (-8.91, -3.41 %), and there was some evidence of an inverse association with dairy protein and calcium. There was no evidence of any dietary associations with IGFBP-3 or IGF-II. CONCLUSIONS: Diet is associated with IGF-I and IGFBP-2 levels in men in the UK, and these peptides warrant further investigation as part of randomized trials of dietary interventions to reduce the risk or progression of prostate cancer. There is no evidence that IGF-II or IGFBP-3 are mediators of dietary associations with prostate cancer. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/22527168/A_cross_sectional_analysis_of_the_association_between_diet_and_insulin_like_growth_factor__IGF__I_IGF_II_IGF_binding_protein__IGFBP__2_and_IGFBP_3_in_men_in_the_United_Kingdom_ L2 - https://doi.org/10.1007/s10552-012-9961-6 DB - PRIME DP - Unbound Medicine ER -