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Increased incidence of symptomatic peripheral neuropathy among adults receiving stavudine- versus zidovudine-based antiretroviral regimens in Kenya.
J Neurovirol. 2012 Jun; 18(3):200-4.JN

Abstract

The incidence of peripheral neuropathy (PN) among adults initiating antiretroviral therapy (ART) containing stavudine (d4T) versus zidovudine (ZDV) is not well described. We compared 1-year incidence between d4T- and ZDV-based regimens in adults initiating ART in a programmatic setting in Kenya. Of 1,848 adults on ART, 1,579 (85 %) initiated d4T-based and 269 (15 %) initiated ZDV-based regimens. One-year incidence of symptomatic PN per 100 person-years was 21.9 (n=236) among d4T users and 6.9 (n=7) among ZDV users (P=0.0002). D4T was associated with 2.7 greater risk of PN than ZDV (adjusted hazard ratio, 2.7, P=0.009). In settings with continued d4T use, such as Africa, the effects of d4T on PN compared to ZDV should be considered when choosing ART regimens.

Authors+Show Affiliations

Department of Global Health, University of Washington, Seattle, WA 98104-2499, USA. mcgrathc@u.washington.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

22528481

Citation

McGrath, Christine J., et al. "Increased Incidence of Symptomatic Peripheral Neuropathy Among Adults Receiving Stavudine- Versus Zidovudine-based Antiretroviral Regimens in Kenya." Journal of Neurovirology, vol. 18, no. 3, 2012, pp. 200-4.
McGrath CJ, Njoroge J, John-Stewart GC, et al. Increased incidence of symptomatic peripheral neuropathy among adults receiving stavudine- versus zidovudine-based antiretroviral regimens in Kenya. J Neurovirol. 2012;18(3):200-4.
McGrath, C. J., Njoroge, J., John-Stewart, G. C., Kohler, P. K., Benki-Nugent, S. F., Thiga, J. W., Etyang, A., & Chung, M. H. (2012). Increased incidence of symptomatic peripheral neuropathy among adults receiving stavudine- versus zidovudine-based antiretroviral regimens in Kenya. Journal of Neurovirology, 18(3), 200-4. https://doi.org/10.1007/s13365-012-0098-x
McGrath CJ, et al. Increased Incidence of Symptomatic Peripheral Neuropathy Among Adults Receiving Stavudine- Versus Zidovudine-based Antiretroviral Regimens in Kenya. J Neurovirol. 2012;18(3):200-4. PubMed PMID: 22528481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased incidence of symptomatic peripheral neuropathy among adults receiving stavudine- versus zidovudine-based antiretroviral regimens in Kenya. AU - McGrath,Christine J, AU - Njoroge,Julia, AU - John-Stewart,Grace C, AU - Kohler,Pamela K, AU - Benki-Nugent,Sarah F, AU - Thiga,Joan W, AU - Etyang,Anthony, AU - Chung,Michael H, Y1 - 2012/04/17/ PY - 2012/01/02/received PY - 2012/03/28/accepted PY - 2012/03/26/revised PY - 2012/4/25/entrez PY - 2012/4/25/pubmed PY - 2012/12/13/medline SP - 200 EP - 4 JF - Journal of neurovirology JO - J Neurovirol VL - 18 IS - 3 N2 - The incidence of peripheral neuropathy (PN) among adults initiating antiretroviral therapy (ART) containing stavudine (d4T) versus zidovudine (ZDV) is not well described. We compared 1-year incidence between d4T- and ZDV-based regimens in adults initiating ART in a programmatic setting in Kenya. Of 1,848 adults on ART, 1,579 (85 %) initiated d4T-based and 269 (15 %) initiated ZDV-based regimens. One-year incidence of symptomatic PN per 100 person-years was 21.9 (n=236) among d4T users and 6.9 (n=7) among ZDV users (P=0.0002). D4T was associated with 2.7 greater risk of PN than ZDV (adjusted hazard ratio, 2.7, P=0.009). In settings with continued d4T use, such as Africa, the effects of d4T on PN compared to ZDV should be considered when choosing ART regimens. SN - 1538-2443 UR - https://www.unboundmedicine.com/medline/citation/22528481/Increased_incidence_of_symptomatic_peripheral_neuropathy_among_adults_receiving_stavudine__versus_zidovudine_based_antiretroviral_regimens_in_Kenya_ L2 - https://dx.doi.org/10.1007/s13365-012-0098-x DB - PRIME DP - Unbound Medicine ER -