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Radiation Macular Edema after Ru-106 Plaque Brachytherapy for Choroidal Melanoma Resolved by an Intravitreal Dexamethasone 0.7-mg Implant.
Case Rep Ophthalmol. 2012 Jan; 3(1):71-6.CR

Abstract

PURPOSE

To report the effective treatment of radiation macular edema following ruthenium-106 plaque brachytherapy for a choroidal melanoma with a dexamethasone 0.7-mg (Ozurdex(®)) intravitreal implant.

METHODS

An interventional case report with optical coherence tomography (OCT) scans.

RESULTS

A 65-year-old Caucasian woman was suffering from radiation macular edema following ruthenium-106 plaque brachytherapy for a choroidal melanoma on her left eye. She had undergone one intravitreal injection of 0.5 mg bevacizumab (Avastin(®), Genentech/Roche) in the following months without functional or anatomical improvement. Seven months after the development of radiation macular edema, she received a single intravitreal injection of dexamethasone 0.7 mg (Ozurdex). Four weeks following the injection, her best-corrected visual acuity improved from 0.3 to 0.5. Radiation macular edema resolved with a reduction of central retinal thickness from 498 μm before Ozurdex injection to 224 μm after Ozurdex injection, as measured by OCT scan.

CONCLUSION

Dexamethasone 0.7 mg (Ozurdex) has proven to be an effective treatment option in retinal vein occlusion and noninfectious uveitis. It can also be considered as off-label treatment in radiation macular edema following ruthenium-106 plaque brachytherapy for a choroidal melanoma.

Authors+Show Affiliations

Department of Ophthalmology, University of Catania, Catania, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports

Language

eng

PubMed ID

22529805

Citation

Russo, Andrea, et al. "Radiation Macular Edema After Ru-106 Plaque Brachytherapy for Choroidal Melanoma Resolved By an Intravitreal Dexamethasone 0.7-mg Implant." Case Reports in Ophthalmology, vol. 3, no. 1, 2012, pp. 71-6.
Russo A, Avitabile T, Uva M, et al. Radiation Macular Edema after Ru-106 Plaque Brachytherapy for Choroidal Melanoma Resolved by an Intravitreal Dexamethasone 0.7-mg Implant. Case Rep Ophthalmol. 2012;3(1):71-6.
Russo, A., Avitabile, T., Uva, M., Faro, S., Franco, L., Sanfilippo, M., Gulisano, S., Toro, M., De Grande, V., Rametta, S., Foti, L., Longo, A., & Reibaldi, M. (2012). Radiation Macular Edema after Ru-106 Plaque Brachytherapy for Choroidal Melanoma Resolved by an Intravitreal Dexamethasone 0.7-mg Implant. Case Reports in Ophthalmology, 3(1), 71-6. https://doi.org/10.1159/000337144
Russo A, et al. Radiation Macular Edema After Ru-106 Plaque Brachytherapy for Choroidal Melanoma Resolved By an Intravitreal Dexamethasone 0.7-mg Implant. Case Rep Ophthalmol. 2012;3(1):71-6. PubMed PMID: 22529805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Radiation Macular Edema after Ru-106 Plaque Brachytherapy for Choroidal Melanoma Resolved by an Intravitreal Dexamethasone 0.7-mg Implant. AU - Russo,Andrea, AU - Avitabile,Teresio, AU - Uva,Maurizio, AU - Faro,Salvatore, AU - Franco,Livio, AU - Sanfilippo,Marisa, AU - Gulisano,Seby, AU - Toro,Mario, AU - De Grande,Vittorio, AU - Rametta,Stefania, AU - Foti,Laura, AU - Longo,Antonio, AU - Reibaldi,Michele, Y1 - 2012/02/25/ PY - 2012/4/25/entrez PY - 2012/4/25/pubmed PY - 2012/4/25/medline KW - Choroidal melanoma KW - Dexamethasone 0.7 mg KW - Macular edema KW - Ozurdex® KW - Ru-106 plaque SP - 71 EP - 6 JF - Case reports in ophthalmology JO - Case Rep Ophthalmol VL - 3 IS - 1 N2 - PURPOSE: To report the effective treatment of radiation macular edema following ruthenium-106 plaque brachytherapy for a choroidal melanoma with a dexamethasone 0.7-mg (Ozurdex(®)) intravitreal implant. METHODS: An interventional case report with optical coherence tomography (OCT) scans. RESULTS: A 65-year-old Caucasian woman was suffering from radiation macular edema following ruthenium-106 plaque brachytherapy for a choroidal melanoma on her left eye. She had undergone one intravitreal injection of 0.5 mg bevacizumab (Avastin(®), Genentech/Roche) in the following months without functional or anatomical improvement. Seven months after the development of radiation macular edema, she received a single intravitreal injection of dexamethasone 0.7 mg (Ozurdex). Four weeks following the injection, her best-corrected visual acuity improved from 0.3 to 0.5. Radiation macular edema resolved with a reduction of central retinal thickness from 498 μm before Ozurdex injection to 224 μm after Ozurdex injection, as measured by OCT scan. CONCLUSION: Dexamethasone 0.7 mg (Ozurdex) has proven to be an effective treatment option in retinal vein occlusion and noninfectious uveitis. It can also be considered as off-label treatment in radiation macular edema following ruthenium-106 plaque brachytherapy for a choroidal melanoma. SN - 1663-2699 UR - https://www.unboundmedicine.com/medline/citation/22529805/Radiation_Macular_Edema_after_Ru_106_Plaque_Brachytherapy_for_Choroidal_Melanoma_Resolved_by_an_Intravitreal_Dexamethasone_0_7_mg_Implant_ L2 - https://www.karger.com?DOI=10.1159/000337144 DB - PRIME DP - Unbound Medicine ER -
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