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Celiac disease in children with type 1 diabetes: impact of gluten free diet on diabetes management.
Acta Biomed 2010; 81(3):165-70AB

Abstract

Background and aim of the work the coexistence of Type 1 Diabetes (T1D) and celiac disease (CD) has been long established.

METHODS

Between January 2000 and December 2009, biopsy-proven CD was diagnosed in 12 children with T1D, giving a prevalence of 4.8 % in our out-patient clinic population. For each patient with coexisting T1D and CD, two control subjects with T1D and without CD who matched for age, sex and duration of diabetes were chosen. Prospective study follow up lasted 24 months. At the enrolment time, and at 2-month intervals, time from diagnosis of T1D to diagnosis of CD, presence of gastrointestinal symptoms, HbA1c value, body mass index (BMI), Height and Weight SDS were collected by a single observer. Daily insulin requirements were also retained.

RESULTS

In 3 children, CD predated the onset of T1D and these children were excluded from the analysis. The 9 children who subsequently developed CD became earlier diabetic than control group (p=0.002). Eight of these children had CD diagnosis within 1 year after T1D onset. Seven out of 9 children were positive for TTG antibodies and all were positive for EMA. A significant increase in insulin requirement was found in CD children after 1 year of GFD (p= 0.02). The mean HbAlc value in CD children was higher than in the control subjects (p<0.01).A significant increase in the insulin requirement after 1 year in the GFD compliant children was found. There was a significant improvement in height-SDS after institution of GFD in the GFD-compliant children. Families of children with both T1D and CD reported higher burden than those affected by T1D only (p=0.001). The health care providers perceived family burden to increase with CD appearance (p<0.05).

CONCLUSION

Our study supports the importance of screening for CD in children with T1D 1. The early treatment with GFD of biopsy-confirmed CD children promotes a significant catch-up growth and prevents a growth failure during the follow-up.

Authors+Show Affiliations

Regional Centre for Children and Adolescents with Diabetes, Department of Paediatrics, University Hospital of Parma, Parma, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22530453

Citation

Sponzilli, Ivonne, et al. "Celiac Disease in Children With Type 1 Diabetes: Impact of Gluten Free Diet On Diabetes Management." Acta Bio-medica : Atenei Parmensis, vol. 81, no. 3, 2010, pp. 165-70.
Sponzilli I, Chiari G, Iovane B, et al. Celiac disease in children with type 1 diabetes: impact of gluten free diet on diabetes management. Acta Biomed. 2010;81(3):165-70.
Sponzilli, I., Chiari, G., Iovane, B., Scarabello, C., Gkliati, D., Monti, G., ... Vanelli, M. (2010). Celiac disease in children with type 1 diabetes: impact of gluten free diet on diabetes management. Acta Bio-medica : Atenei Parmensis, 81(3), pp. 165-70.
Sponzilli I, et al. Celiac Disease in Children With Type 1 Diabetes: Impact of Gluten Free Diet On Diabetes Management. Acta Biomed. 2010;81(3):165-70. PubMed PMID: 22530453.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Celiac disease in children with type 1 diabetes: impact of gluten free diet on diabetes management. AU - Sponzilli,Ivonne, AU - Chiari,Giovanni, AU - Iovane,Brunella, AU - Scarabello,Chiara, AU - Gkliati,Dimitra, AU - Monti,Giorgia, AU - Fanciullo,Lavinia, AU - de'Angelis,Gian Luigi, AU - Vanelli,Maurizio, PY - 2012/4/26/entrez PY - 2010/12/1/pubmed PY - 2012/5/23/medline SP - 165 EP - 70 JF - Acta bio-medica : Atenei Parmensis JO - Acta Biomed VL - 81 IS - 3 N2 - UNLABELLED: Background and aim of the work the coexistence of Type 1 Diabetes (T1D) and celiac disease (CD) has been long established. METHODS: Between January 2000 and December 2009, biopsy-proven CD was diagnosed in 12 children with T1D, giving a prevalence of 4.8 % in our out-patient clinic population. For each patient with coexisting T1D and CD, two control subjects with T1D and without CD who matched for age, sex and duration of diabetes were chosen. Prospective study follow up lasted 24 months. At the enrolment time, and at 2-month intervals, time from diagnosis of T1D to diagnosis of CD, presence of gastrointestinal symptoms, HbA1c value, body mass index (BMI), Height and Weight SDS were collected by a single observer. Daily insulin requirements were also retained. RESULTS: In 3 children, CD predated the onset of T1D and these children were excluded from the analysis. The 9 children who subsequently developed CD became earlier diabetic than control group (p=0.002). Eight of these children had CD diagnosis within 1 year after T1D onset. Seven out of 9 children were positive for TTG antibodies and all were positive for EMA. A significant increase in insulin requirement was found in CD children after 1 year of GFD (p= 0.02). The mean HbAlc value in CD children was higher than in the control subjects (p<0.01).A significant increase in the insulin requirement after 1 year in the GFD compliant children was found. There was a significant improvement in height-SDS after institution of GFD in the GFD-compliant children. Families of children with both T1D and CD reported higher burden than those affected by T1D only (p=0.001). The health care providers perceived family burden to increase with CD appearance (p<0.05). CONCLUSION: Our study supports the importance of screening for CD in children with T1D 1. The early treatment with GFD of biopsy-confirmed CD children promotes a significant catch-up growth and prevents a growth failure during the follow-up. SN - 0392-4203 UR - https://www.unboundmedicine.com/medline/citation/22530453/Celiac_disease_in_children_with_type_1_diabetes:_impact_of_gluten_free_diet_on_diabetes_management_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -