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Metabolic risk factors and skin cancer in the Metabolic Syndrome and Cancer Project (Me-Can).
Br J Dermatol. 2012 Jul; 167(1):59-67.BJ

Abstract

BACKGROUND

Little is known about the associations of metabolic aberrations with malignant melanoma (MM) and nonmelanoma skin cancer (NMSC).

OBJECTIVES

To assess the associations between metabolic factors (both individually and combined) and the risk of skin cancer in the large prospective Metabolic Syndrome and Cancer Project (Me-Can).

METHODS

During a mean follow-up of 12 years of the Me-Can cohort, 1728 (41% women) incident MM, 230 (23% women) fatal MM and 1145 (33% women) NMSC were identified. Most NMSC cases (76%) were squamous cell carcinoma (SCC) (873, 33% women). Hazard ratios (HRs) were estimated by Cox proportional hazards regression for quintiles and standardized z-scores (with a mean of 0 and SD of 1) of body mass index (BMI), blood pressure, glucose, cholesterol, triglycerides and for a combined metabolic syndrome score. Risk estimates were corrected for random error in the measurements.

RESULTS

Blood pressure per unit increase of z-score was associated with an increased risk of incident MM cases in men and women [HR 1·17, 95% confidence interval (CI) 1·04-1·31 and HR 1·18, 95% CI 1·03-1·36, respectively] and fatal MM cases among women (HR 2·39, 95% CI 1·58-3·64). In men, all quintiles for BMI above the reference were associated with a higher risk of incident MM. In women, SCC NMSC risk increased across quintiles for glucose levels (P-trend 0·02) and there was a trend with triglyceride concentration (P-trend 0·09).

CONCLUSION

These findings suggest that mechanisms linked to blood pressure may be involved in the pathogenesis of MM. SCC NMSC in women could be related to glucose and lipid metabolism.

Authors+Show Affiliations

Institute of Epidemiology and Medical Biometry, Ulm University, Helmholtzstr. 22, 89081 Ulm, Germany. gabriele.nagel@uni-ulm.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22530854

Citation

Nagel, G, et al. "Metabolic Risk Factors and Skin Cancer in the Metabolic Syndrome and Cancer Project (Me-Can)." The British Journal of Dermatology, vol. 167, no. 1, 2012, pp. 59-67.
Nagel G, Bjørge T, Stocks T, et al. Metabolic risk factors and skin cancer in the Metabolic Syndrome and Cancer Project (Me-Can). Br J Dermatol. 2012;167(1):59-67.
Nagel, G., Bjørge, T., Stocks, T., Manjer, J., Hallmans, G., Edlinger, M., Häggström, C., Engeland, A., Johansen, D., Kleiner, A., Selmer, R., Ulmer, H., Tretli, S., Jonsson, H., Concin, H., Stattin, P., & Lukanova, A. (2012). Metabolic risk factors and skin cancer in the Metabolic Syndrome and Cancer Project (Me-Can). The British Journal of Dermatology, 167(1), 59-67. https://doi.org/10.1111/j.1365-2133.2012.10974.x
Nagel G, et al. Metabolic Risk Factors and Skin Cancer in the Metabolic Syndrome and Cancer Project (Me-Can). Br J Dermatol. 2012;167(1):59-67. PubMed PMID: 22530854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic risk factors and skin cancer in the Metabolic Syndrome and Cancer Project (Me-Can). AU - Nagel,G, AU - Bjørge,T, AU - Stocks,T, AU - Manjer,J, AU - Hallmans,G, AU - Edlinger,M, AU - Häggström,C, AU - Engeland,A, AU - Johansen,D, AU - Kleiner,A, AU - Selmer,R, AU - Ulmer,H, AU - Tretli,S, AU - Jonsson,H, AU - Concin,H, AU - Stattin,P, AU - Lukanova,A, Y1 - 2012/04/24/ PY - 2012/4/26/entrez PY - 2012/4/26/pubmed PY - 2012/10/2/medline SP - 59 EP - 67 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 167 IS - 1 N2 - BACKGROUND: Little is known about the associations of metabolic aberrations with malignant melanoma (MM) and nonmelanoma skin cancer (NMSC). OBJECTIVES: To assess the associations between metabolic factors (both individually and combined) and the risk of skin cancer in the large prospective Metabolic Syndrome and Cancer Project (Me-Can). METHODS: During a mean follow-up of 12 years of the Me-Can cohort, 1728 (41% women) incident MM, 230 (23% women) fatal MM and 1145 (33% women) NMSC were identified. Most NMSC cases (76%) were squamous cell carcinoma (SCC) (873, 33% women). Hazard ratios (HRs) were estimated by Cox proportional hazards regression for quintiles and standardized z-scores (with a mean of 0 and SD of 1) of body mass index (BMI), blood pressure, glucose, cholesterol, triglycerides and for a combined metabolic syndrome score. Risk estimates were corrected for random error in the measurements. RESULTS: Blood pressure per unit increase of z-score was associated with an increased risk of incident MM cases in men and women [HR 1·17, 95% confidence interval (CI) 1·04-1·31 and HR 1·18, 95% CI 1·03-1·36, respectively] and fatal MM cases among women (HR 2·39, 95% CI 1·58-3·64). In men, all quintiles for BMI above the reference were associated with a higher risk of incident MM. In women, SCC NMSC risk increased across quintiles for glucose levels (P-trend 0·02) and there was a trend with triglyceride concentration (P-trend 0·09). CONCLUSION: These findings suggest that mechanisms linked to blood pressure may be involved in the pathogenesis of MM. SCC NMSC in women could be related to glucose and lipid metabolism. SN - 1365-2133 UR - https://www.unboundmedicine.com/medline/citation/22530854/Metabolic_risk_factors_and_skin_cancer_in_the_Metabolic_Syndrome_and_Cancer_Project__Me_Can__ L2 - https://doi.org/10.1111/j.1365-2133.2012.10974.x DB - PRIME DP - Unbound Medicine ER -