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Modulating behavioral inhibition by tDCS combined with cognitive training.
Exp Brain Res. 2012 Jun; 219(3):363-8.EB

Abstract

Cognitive training is an effective tool to improve a variety of cognitive functions, and a small number of studies have now shown that brain stimulation accompanying these training protocols can enhance their effects. In the domain of behavioral inhibition, little is known about how training can affect this skill. As for transcranial direct current stimulation (tDCS), it was previously found that stimulation over the right inferior frontal gyrus (rIFG) facilitates behavioral inhibition performance and modulates its electrophysiological correlates. This study aimed to investigate this behavioral facilitation in the context of a learning paradigm by giving tDCS over rIFG repetitively over four consecutive days of training on a behavioral inhibition task (stop signal task (SST)). Twenty-two participants took part; ten participants were assigned to receive anodal tDCS (1.5 mA, 15 min), 12 were assigned to receive training but not active stimulation. There was a significant effect of training on learning and performance in the SST, and the integration of the training and rIFG-tDCS produced a more linear learning slope. Better performance was also found in the active stimulation group. Our findings show that tDCS-combined cognitive training is an effective tool for improving the ability to inhibit responses. The current study could constitute a step toward the use of tDCS and cognitive training as a therapeutic tool for cognitive control impairments in conditions such as attention-deficit hyperactivity disorder (ADHD) or schizophrenia.

Authors+Show Affiliations

Institute of Cognitive Neuroscience, University College London, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22532165

Citation

Ditye, Thomas, et al. "Modulating Behavioral Inhibition By tDCS Combined With Cognitive Training." Experimental Brain Research, vol. 219, no. 3, 2012, pp. 363-8.
Ditye T, Jacobson L, Walsh V, et al. Modulating behavioral inhibition by tDCS combined with cognitive training. Exp Brain Res. 2012;219(3):363-8.
Ditye, T., Jacobson, L., Walsh, V., & Lavidor, M. (2012). Modulating behavioral inhibition by tDCS combined with cognitive training. Experimental Brain Research, 219(3), 363-8. https://doi.org/10.1007/s00221-012-3098-4
Ditye T, et al. Modulating Behavioral Inhibition By tDCS Combined With Cognitive Training. Exp Brain Res. 2012;219(3):363-8. PubMed PMID: 22532165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulating behavioral inhibition by tDCS combined with cognitive training. AU - Ditye,Thomas, AU - Jacobson,Liron, AU - Walsh,Vincent, AU - Lavidor,Michal, Y1 - 2012/04/25/ PY - 2012/02/07/received PY - 2012/04/13/accepted PY - 2012/4/26/entrez PY - 2012/4/26/pubmed PY - 2013/3/12/medline SP - 363 EP - 8 JF - Experimental brain research JO - Exp Brain Res VL - 219 IS - 3 N2 - Cognitive training is an effective tool to improve a variety of cognitive functions, and a small number of studies have now shown that brain stimulation accompanying these training protocols can enhance their effects. In the domain of behavioral inhibition, little is known about how training can affect this skill. As for transcranial direct current stimulation (tDCS), it was previously found that stimulation over the right inferior frontal gyrus (rIFG) facilitates behavioral inhibition performance and modulates its electrophysiological correlates. This study aimed to investigate this behavioral facilitation in the context of a learning paradigm by giving tDCS over rIFG repetitively over four consecutive days of training on a behavioral inhibition task (stop signal task (SST)). Twenty-two participants took part; ten participants were assigned to receive anodal tDCS (1.5 mA, 15 min), 12 were assigned to receive training but not active stimulation. There was a significant effect of training on learning and performance in the SST, and the integration of the training and rIFG-tDCS produced a more linear learning slope. Better performance was also found in the active stimulation group. Our findings show that tDCS-combined cognitive training is an effective tool for improving the ability to inhibit responses. The current study could constitute a step toward the use of tDCS and cognitive training as a therapeutic tool for cognitive control impairments in conditions such as attention-deficit hyperactivity disorder (ADHD) or schizophrenia. SN - 1432-1106 UR - https://www.unboundmedicine.com/medline/citation/22532165/full_citation/Modulating_behavioral_inhibition_by_tDCS_combined_with_cognitive_training_ L2 - https://dx.doi.org/10.1007/s00221-012-3098-4 DB - PRIME DP - Unbound Medicine ER -